| Sequence 1: | NP_066956.1 | Gene: | RNASEL / 6041 | HGNCID: | 10050 | Length: | 741 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001097839.1 | Gene: | Ire1 / 42358 | FlyBaseID: | FBgn0261984 | Length: | 1074 | Species: | Drosophila melanogaster |
| Alignment Length: | 814 | Identity: | 174/814 - (21%) |
|---|---|---|---|
| Similarity: | 301/814 - (36%) | Gaps: | 257/814 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Human 50 NVNFQEEEGGWTPLHNAV----QMSRE------------DIVELLLRHGADPVLRKKNGATPFIL 98
Human 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF---LYKRGANVNLRRKTKED 160
Human 161 QERLRKGGATALMDAAEKGHVEV-----LKILLDEMGADVNA----------------------- 197
Human 198 ----CDNMGRN-----------------ALIH------ALLSSDD---SDVEAITH-LLLDHGAD 231
Human 232 VNVRG---ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL---------- 283
Human 284 -----KLKKIAE------LLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWK 337
Human 338 PQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGG-IYLGFYEKQEVAVK-------TF 394
Human 395 CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459
Human 460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-----SKKAAHLADFDKSIK---------- 509
Human 510 ---------WAGDPQEVKR-------DLEDLGRLVLYVVKKGSISFED-LKAQSN-----EEVVQ 552
Human 553 LSPDEETKD--------LIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRK 609
Human 610 SESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHID 674
Human 675 EEKHKKMKLKIG----DPSLYFQKTFPDLVIYVY 704 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| RNASEL | NP_066956.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..21 | ||
| ANK repeat | 24..56 | CDD:293786 | 2/5 (40%) | ||
| ANK 1 | 24..53 | 1/2 (50%) | |||
| Ank_2 | 29..122 | CDD:289560 | 18/87 (21%) | ||
| ANK 2 | 58..87 | 9/44 (20%) | |||
| ANK | 59..188 | CDD:238125 | 30/152 (20%) | ||
| ANK repeat | 59..89 | CDD:293786 | 10/45 (22%) | ||
| ANK repeat | 91..122 | CDD:293786 | 6/30 (20%) | ||
| ANK 3 | 91..120 | 6/28 (21%) | |||
| Ank_2 | 96..199 | CDD:289560 | 24/137 (18%) | ||
| ANK repeat | 124..154 | CDD:293786 | 7/32 (22%) | ||
| ANK 4 | 124..153 | 7/31 (23%) | |||
| ANK repeat | 167..199 | CDD:293786 | 10/63 (16%) | ||
| ANK 5 | 167..197 | 9/34 (26%) | |||
| Ank_2 | 172..270 | CDD:289560 | 30/159 (19%) | ||
| ANK | 196..321 | CDD:238125 | 32/202 (16%) | ||
| ANK repeat | 201..236 | CDD:293786 | 11/61 (18%) | ||
| ANK 6 | 201..234 | 11/59 (19%) | |||
| 2-5A binding (P-loop) 1 | 229..242 | 5/15 (33%) | |||
| ANK 7 | 238..268 | 9/29 (31%) | |||
| Ank_2 | 243..326 | CDD:289560 | 17/103 (17%) | ||
| 2-5A binding (P-loop) 2 | 253..275 | 4/21 (19%) | |||
| ANK repeat | 272..326 | CDD:293786 | 11/74 (15%) | ||
| ANK 8 | 272..301 | 8/49 (16%) | |||
| ANK 9 | 303..329 | 2/25 (8%) | |||
| PKc_like | 375..587 | CDD:304357 | 67/264 (25%) | ||
| Pkinase | 387..586 | CDD:278497 | 63/250 (25%) | ||
| RNase_RNase-L | 590..708 | CDD:199218 | 25/119 (21%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 715..741 | ||||
| Ire1 | NP_001097839.1 | Luminal_IRE1 | 53..321 | CDD:188875 | 30/142 (21%) |
| STKc_IRE1 | 545..813 | CDD:270884 | 70/279 (25%) | ||
| S_TKc | 552..812 | CDD:214567 | 68/271 (25%) | ||
| RNase_Ire1 | 817..941 | CDD:199217 | 25/118 (21%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG1027 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||