DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RNASEL and Ire1

DIOPT Version :10

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:NP_001097839.1 Gene:Ire1 / 42358 FlyBaseID:FBgn0261984 Length:1074 Species:Drosophila melanogaster


Alignment Length:814 Identity:174/814 - (21%)
Similarity:301/814 - (36%) Gaps:257/814 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    50 NVNFQEEEGGWTPLHNAV----QMSRE------------DIVELLLRHGADPVLRKKNGATPFIL 98
            |:.|.:        :|||    ::::|            .||.|..:||  ..|.:::.::|.:.
  Fly   210 NITFYD--------YNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHG--KFLWQRDLSSPVVA 264

Human    99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF---LYKRGANVNLRRKTKED 160
            |.:.|...||.:..:..:|      ..:.|.:|.:..|.|..:|.   ||           ..|.
  Fly   265 AFLLGPDGLLSVPFTTVSD------EAYQAILEESKTGNVNTVKLFQSLY-----------VGEH 312

Human   161 QERLRKGGATALMDAAEKGHVEV-----LKILLDEMGADVNA----------------------- 197
            |:     |..||....:|....:     :| |||....|.|:                       
  Fly   313 QK-----GLYALPSLVDKNTPRISTAPPIK-LLDGPTGDQNSNQETDPRTIYINDVLQEHAGIML 371

Human   198 ----CDNMGRN-----------------ALIH------ALLSSDD---SDVEAITH-LLLDHGAD 231
                ..|.|..                 |.||      .||::::   :|:...|. .|::.|.|
  Fly   372 GHYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKNAADIGVQTDPELVEIGID 436

Human   232 VNVRG---ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL---------- 283
            ....|   .|.|| :||....|    ||..:.:..:|    ...||...:|.|.:          
  Fly   437 QRTNGNTINRTKT-IILQNSNK----VQAFINEWFME----HPSGKVHQILIVIVLGMIALFWYT 492

Human   284 -----KLKKIAE------LLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWK 337
                 :|:|.:|      .:.:.|::...|                   |:|:..:    |||  
  Fly   493 CSTMRELQKQSENGSKTFAIAQNGSNGSTG-------------------SNGSNAN----AED-- 532

Human   338 PQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGG-IYLGFYEKQEVAVK-------TF 394
                     |.||.. .:..:||:.|..:|  .:....||. ::.|.:|::.||||       ||
  Fly   533 ---------LVDLGN-GQVRVGKISFSTNE--VLGKGCEGTFVFKGTFEERFVAVKRLLPECFTF 585

Human   395 CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459
                  |.|||:.|:.|..:.::|.::.:|..|...::.|.||..||:...:..|..:::|..|.
  Fly   586 ------ADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDV 644

Human   460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-----SKKAAHLADFDKSIK---------- 509
            :  .|||.....:..|| |....|:|::|||:||.     .|....::||....|          
  Fly   645 W--QVLSQAASGLSHLH-SLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSR 706

Human   510 ---------WAGDPQEVKR-------DLEDLGRLVLYVVKKGSISFED-LKAQSN-----EEVVQ 552
                     |.. |:.::.       |:..||.:..||:..|..:|.| ||.|:|     ..:.:
  Fly   707 RSGVTGTDGWIA-PEMMRSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAK 770

Human   553 LSPDEETKD--------LIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRK 609
            |.|:::::|        ||..:.|.....|.....:..||.||........|::|.:.  ::..:
  Fly   771 LRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDR--VEKLQ 833

Human   610 SESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHID 674
            ..:|.|:.|:  .:......|.|...::..:...:.|:   || :...:|.|||:.:||...|..
  Fly   834 FHAEPLKSLE--KNGRIVVLDDWNVHLDPMITDDLRKY---RG-YMGASVRDLLRALRNKKHHYH 892

Human   675 EEKHKKMKLKIG----DPSLYFQKTFPDLVIYVY 704
            |......|: :|    :.:.|:...||.|:.:.|
  Fly   893 ELTPAAQKM-LGCIPHEFTNYWVDRFPQLISHAY 925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786 2/5 (40%)
ANK 1 24..53 1/2 (50%)
ANKYR 25..297 CDD:440430 66/348 (19%)
ANK 2 58..87 9/44 (20%)
ANK repeat 59..89 CDD:293786 10/45 (22%)
ANK repeat 91..122 CDD:293786 6/30 (20%)
ANK 3 91..120 6/28 (21%)
ANK repeat 124..154 CDD:293786 7/32 (22%)
ANK 4 124..153 7/31 (23%)
ANK repeat 167..199 CDD:293786 10/63 (16%)
ANK 5 167..197 9/34 (26%)
ANK repeat 201..236 CDD:293786 11/61 (18%)
ANK 6 201..234 11/59 (19%)
2-5A binding (P-loop) 1 229..242 5/15 (33%)
ANK 7 238..268 9/29 (31%)
2-5A binding (P-loop) 2 253..275 4/21 (19%)
ANK repeat 272..326 CDD:293786 11/74 (15%)
ANK 8 272..301 8/49 (16%)
ANK 9 303..329 2/25 (8%)
Protein Kinases, catalytic domain 375..587 CDD:473864 67/264 (25%)
RNase_RNase-L 590..708 CDD:199218 25/119 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
Ire1NP_001097839.1 Luminal_IRE1 53..321 CDD:188875 30/142 (21%)
STKc_IRE1 545..813 CDD:270884 70/279 (25%)
RNase_Ire1 817..941 CDD:199217 25/118 (21%)
Blue background indicates that the domain is not in the aligned region.

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