DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and nsy-1

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_001370698.1	Gene:	nsy-1 / 24104671	WormBaseID:	WBGene00003822	Length:	1498	Species:	Caenorhabditis elegans

Alignment Length:	760	Identity:	139/760 - (18%)
Similarity:	259/760 - (34%)	Gaps:	238/760 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   104 SVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG 168
            :|.|..|...|||..|..:::....:.|.:|..                         |..:|..
Worm   429 AVVLNSLLGRKGALQNLMEYWDVATYFEVSVLA-------------------------ENYQKAC 468

Human   169 ATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD-----------VEAIT 222
            ..|||....|..|..||..::.:.. :|.|         .|.:|..:.:           :||..
Worm   469 EAALMMVKLKPPVWYLKSTMENIKL-INRC---------AATISPIEKEKQQFLFWSEFFMEATE 523

Human   223 HLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAV--ELKL 285
                   ||.::...|... |||.:.|:        ....::.:|:.:.   |.:|..|  ..:.
Worm   524 -------ADTDISCPRYPV-LILELNKE--------FTPSYLTLNNEEG---TVILSHVLENSQQ 569

Human   286 KKI--AELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKED------FHPPAEDWK---PQ 339
            |||  :||   ||..          |.::..:.:|. ::...::|      .|..::|:.   |.
Worm   570 KKIHQSEL---RGIH----------RWHFARNNIKA-VTESKRDDRQLFLYVHENSDDFNLLFPT 620

Human   340 SSHWGAALKDLHR-------------IYRPMIGKLKFFIDEKYKIADTSE-----GGIYLGFY-- 384
            .:|...|..|:..             :..|...|::|    :|::::::|     .|.|...|
Worm   621 KAHCKKAYDDMKSMADVADGNYQGRVLSNPDNEKIRF----EYELSNSNERVVLGKGTYGTVYAA 681

Human   385 -----EKQ----EVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF-----YGSESHRGHLFVCVT 435
                 ::|    |:.||...|..| ...|:| |.|:..::::|.:     .|.:....|..:.:.
Worm   682 RDMDTQRQIVVKEIEVKYDEEVQP-LMEEIS-LHSTLCHANIVQYLGCDLVGKDGSNDHFLIFME 744

Human   436 -LCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDS-KKA 498
             :...:|.:.|....|...||..:.:.:.:|..: |.:.||.:    .|:|::..|:|::: ...
Worm   745 HVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGL-KYLHELKI----VHRDIKGDNVLVNTYSGV 804

Human   499 AHLADFDKSIKWAG-DP---------QEVKRDLEDLGR-------------LVLYVVKKGSISFE 540
            ..::||....:.|| :|         |.:..::.|.|:             ..:..:..|...|.
Worm   805 CKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFV 869

Human   541 DLK----AQSNEEVVQLSP------DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWE---SR 592
            :::    |.....:.:..|      .|:.::.|...|.|....|....|||..||.:...   ||
Worm   870 EMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIYHNHHSISR 934

Human   593 YR---------TLRNVGNESDIKTR-KSESEILRLLQ------------PGPSEHSKSFDKWTTK 635
            .|         |...:.::.:.|.: |::.|:||...            |.|...|.:.....:.
Worm   935 TRSGSINKKPATKIELNHDKEKKEKSKNQREMLRSTSHIGGMGVVERSPPTPEPMSATLTAGFSH 999

Human   636 INECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTF---- 696
            :                  :..||.:.|...|         :.||:.|||....   .:||
Worm  1000 V------------------HSQTVSNALSTAR---------EEKKLHLKIDHAR---NRTFSSSS 1034

Human   697 --PDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASP 739
              ||......|.:.:..:     |...|:.|..|.......:.||
Worm  1035 PVPDGQSSAGTNMSHPGF-----QLSQPSSPIVDDTNHPHLIVSP 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786
		ANK 1	24..53
		Ank_2	29..122	CDD:289560	7/17 (41%)
		ANK 2	58..87
		ANK	59..188	CDD:238125	18/83 (22%)
		ANK repeat	59..89	CDD:293786
		ANK repeat	91..122	CDD:293786	7/17 (41%)
		ANK 3	91..120		6/15 (40%)
		Ank_2	96..199	CDD:289560	19/94 (20%)
		ANK repeat	124..154	CDD:293786	2/29 (7%)
		ANK 4	124..153		2/28 (7%)
		ANK repeat	167..199	CDD:293786	8/31 (26%)
		ANK 5	167..197		7/29 (24%)
		Ank_2	172..270	CDD:289560	20/108 (19%)
		ANK	196..321	CDD:238125	26/139 (19%)
		ANK repeat	201..236	CDD:293786	6/45 (13%)
		ANK 6	201..234		6/43 (14%)
		2-5A binding (P-loop) 1	229..242		3/12 (25%)
		ANK 7	238..268		5/29 (17%)
		Ank_2	243..326	CDD:289560	17/86 (20%)
		2-5A binding (P-loop) 2	253..275		1/21 (5%)
		ANK repeat	272..326	CDD:293786	12/57 (21%)
		ANK 8	272..301		10/32 (31%)
		ANK 9	303..329		3/31 (10%)
		PKc_like	375..587	CDD:304357	52/267 (19%)
		Pkinase	387..586	CDD:278497	47/242 (19%)
		RNase_RNase-L	590..708	CDD:199218	26/148 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741		6/25 (24%)
nsy-1	NP_001370698.1	DUF4071	136..517	CDD:404208	22/122 (18%)
		ASK_PH	529..631	CDD:408809	24/127 (19%)
		STKc_ASK	655..925	CDD:270794	53/280 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910