DRSC/TRiP Functional Genomics Resources

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Protein Alignment RNASEL and F36D3.5

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:NP_507181.3 Gene:F36D3.5 / 185352 WormBaseID:WBGene00009471 Length:1215 Species:Caenorhabditis elegans


Alignment Length:461 Identity:95/461 - (20%)
Similarity:156/461 - (33%) Gaps:148/461 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALK-FLYKRGANVNLRRKTKE 159
            :|.....||:.|:.|.....        ||||.      .|:.|.:. :||..|..::..|:.:.
 Worm   818 YIFLICIGSMILIGLLCVVA--------YGFTK------NGRAKYMNLYLYYFGKPLDYERRWRY 868

Human   160 DQERLRKGGATALMDAA-EKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223
            ......:||...|:||. |.....|:|.:  :|||.:||.:..|..||..|..|:    :..|..
 Worm   869 SLFLDNQGGKNTLLDAVREINKTHVVKAV--KMGAYINAFNKFGNTALHVATKSA----LPEIVK 927

Human   224 LLLDHGADVNVRGERGKTP--LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLK 286
            :|::||||:.:.....|||  :|......|        .::.:|                  ||:
 Worm   928 ILIEHGADLTLLNTLNKTPEQMIPLASPDH--------SKDMVE------------------KLE 966

Human   287 KIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSH-WGAALKDL 350
            ||..|..|                           ::|.|.....| :.:...|.| |.....| 
 Worm   967 KIRMLYKK---------------------------ANGKKYRMSVP-QKFPATSFHIWMDERTD- 1002

Human   351 HRIYRPMIGKLKFFIDEK------YKIADTSEGGI-------YLGFYEKQEVAVKTFCEGSPRAQ 402
            ::|....:.|.:....::      :.|..|.|.|:       .|.:.....:.||        .|
 Worm  1003 NKITNDFMEKFQAITSDEAAPNTTHVIVKTDENGVLETDDLDLLFWVFNGAIIVK--------EQ 1059

Human   403 REVSCLQSSR----ENSHLVTFYGSESHRGHLF------------------------VCVTLCEQ 439
            ..:.||...:    ::.:||   .|..::|..|                        :.:|.|:.
 Worm  1060 WMIDCLNEEKLIEQDSKYLV---DSVKYKGSTFKTVLQWSEAMAKGAIPYLYGVYAAIVMTECKN 1121

Human   440 --TLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDS--KKAAH 500
              ||...:..|.|..::....:.|.||.|.            .|.|.:|.|..::.|.  ...|:
 Worm  1122 LVTLNTLVAAHGGFMMKTFPGKDAFNVGSR------------PYNHANLGPLFLIHDGTINLKAY 1174

Human   501 LADFDK 506
            .||.||
 Worm  1175 TADPDK 1180

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786
ANK 1 24..53
Ank_2 29..122 CDD:289560 5/25 (20%)
ANK 2 58..87
ANK 59..188 CDD:238125 23/93 (25%)
ANK repeat 59..89 CDD:293786
ANK repeat 91..122 CDD:293786 5/25 (20%)
ANK 3 91..120 5/23 (22%)
Ank_2 96..199 CDD:289560 28/104 (27%)
ANK repeat 124..154 CDD:293786 9/30 (30%)
ANK 4 124..153 9/29 (31%)
ANK repeat 167..199 CDD:293786 13/32 (41%)
ANK 5 167..197 11/30 (37%)
Ank_2 172..270 CDD:289560 28/100 (28%)
ANK 196..321 CDD:238125 25/126 (20%)
ANK repeat 201..236 CDD:293786 11/34 (32%)
ANK 6 201..234 11/32 (34%)
2-5A binding (P-loop) 1 229..242 4/12 (33%)
ANK 7 238..268 6/31 (19%)
Ank_2 243..326 CDD:289560 10/82 (12%)
2-5A binding (P-loop) 2 253..275 1/21 (5%)
ANK repeat 272..326 CDD:293786 7/53 (13%)
ANK 8 272..301 6/28 (21%)
ANK 9 303..329 2/25 (8%)
PKc_like 375..587 CDD:304357 33/171 (19%)
Pkinase 387..586 CDD:278497 30/152 (20%)
RNase_RNase-L 590..708 CDD:199218
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
F36D3.5NP_507181.3 WSN 25..93 CDD:197734
ANK <873..946 CDD:238125 25/78 (32%)
ANK repeat 876..907 CDD:293786 13/32 (41%)
Ank_4 879..930 CDD:290365 17/56 (30%)
ANK repeat 909..940 CDD:293786 11/34 (32%)
BRCT 985..1065 CDD:214602 15/89 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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