DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and C01G10.1

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_506722.2	Gene:	C01G10.1 / 180019	WormBaseID:	WBGene00007230	Length:	1213	Species:	Caenorhabditis elegans

Alignment Length:	608	Identity:	110/608 - (18%)
Similarity:	204/608 - (33%)	Gaps:	216/608 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    23 VEDNHLLIKAVQNEDVDLVQ--QLLEGGANVNFQEEEGGWTPL---------HNAVQMSREDIVE 76
            |.|:...|..::.:..||.:  :||:..:.:..||....:..:         |.|:....|..:.
Worm   722 VFDDASKINGIRGDPKDLYRLFRLLKKSSKLEKQEAAKYFESIKNLDLDFARHEAILKGAEITIS 786

Human    77 LLLRHGADPVLRKKNGATP----------FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFME 131
            .|:.:..:....||.....          :|:....|.:.|:.|.....        ||||.
Worm   787 SLMTYFDEIFGNKKLDIVTIAVDNQLSWIYIIIICIGVMILIGLICIVA--------YGFTQ--- 840

Human   132 AAVYGKVKALK-FLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEK----GHVEVLKILLDEM 191
               .|:.|... :||..|..|:...:.:.......:.|...|:||..:    ..|..:|     .
Worm   841 ---NGRSKYTNLYLYYVGKPVHYENRWRYSLFLDNQDGKNTLLDAVREINKTNAVNAVK-----A 897

Human   192 GADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQ 256
            |:.:||.:..|..||..|..|:    :..|..||:.:|||..:.....:||      ::.:.||.
Worm   898 GSYINAFNKFGNTALHTATKSA----LPEIVKLLIKNGADRELLNTMNRTP------EQMIPLVY 952

Human   257 RLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLL 321
            :.:.::.:|                                             |:|........
Worm   953 KDIPKDKVE---------------------------------------------NFDKIRALYKK 972

Human   322 SHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEK 386
            ::|.|...:.| :.:...|.|                    .:|||:..|..|::      |.||
Worm   973 ANGKKHKMNVP-QKFPTTSFH--------------------IWIDERTDINITNQ------FMEK 1010

Human   387 -------------QEVAVKTFCEGS------------------PRAQREVSCLQS----SRENSH 416
                         ..|.|||...|:                  .:.|..|.||::    .:::.:
Worm  1011 FQAITSDEANSNTTHVIVKTDENGALETDSLDLLLWVFNGAIIVKEQWMVDCLENETVIEQDSKY 1075

Human   417 LV-------TFYG-----SES-HRG---HLF-----VCVTLCEQTLE--ACLDVHRGEDVENEED 458
            ||       ::|.     ||: .:|   :|:     |.:..|:..|:  :.:.:|.|
Worm  1076 LVEKVKYKGSYYNTVLQWSEAMAKGAIPYLYGVYSAVVMVECKNLLKLNSLVAIHGG-------- 1132

Human   459 EFARNVLSSIFKAVQELHL-SCGYTHQDLQPQNILIDSK--KAAHLADFDKS---------IKWA 511
                 |:..:|...:..:: |..|.|.:|.|..::.|.|  .:.:.:|.||.         ||:.
Worm  1133 -----VMMEVFPRKELFNVGSHPYNHANLGPLFLIHDGKINLSVYKSDPDKMYTLFTEEEFIKFM 1192

Human   512 GDPQEVKRDL-EDLGRLVLYVVK 533
                 :|||: :|:....:.|:|
Worm  1193 -----LKRDIVKDISETPISVLK 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	7/33 (21%)
		ANK 1	24..53		6/30 (20%)
		Ank_2	29..122	CDD:289560	17/113 (15%)
		ANK 2	58..87		4/37 (11%)
		ANK	59..188	CDD:238125	26/152 (17%)
		ANK repeat	59..89	CDD:293786	4/38 (11%)
		ANK repeat	91..122	CDD:293786	4/40 (10%)
		ANK 3	91..120		4/38 (11%)
		Ank_2	96..199	CDD:289560	23/107 (21%)
		ANK repeat	124..154	CDD:293786	10/30 (33%)
		ANK 4	124..153		10/29 (34%)
		ANK repeat	167..199	CDD:293786	9/35 (26%)
		ANK 5	167..197		7/33 (21%)
		Ank_2	172..270	CDD:289560	24/101 (24%)
		ANK	196..321	CDD:238125	20/124 (16%)
		ANK repeat	201..236	CDD:293786	11/34 (32%)
		ANK 6	201..234		11/32 (34%)
		2-5A binding (P-loop) 1	229..242		3/12 (25%)
		ANK 7	238..268		5/29 (17%)
		Ank_2	243..326	CDD:289560	6/82 (7%)
		2-5A binding (P-loop) 2	253..275		3/21 (14%)
		ANK repeat	272..326	CDD:293786	3/53 (6%)
		ANK 8	272..301		0/28 (0%)
		ANK 9	303..329		4/25 (16%)
		PKc_like	375..587	CDD:304357	44/230 (19%)
		Pkinase	387..586	CDD:278497	41/205 (20%)
		RNase_RNase-L	590..708	CDD:199218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
C01G10.1	NP_506722.2	WSN	23..91	CDD:197734
		ANK	<872..944	CDD:238125	20/80 (25%)
		ANK repeat	907..938	CDD:293786	11/34 (32%)
		BRCT	991..1063	CDD:214602	16/97 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900