DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RNASEL and mask-1

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:NP_001263772.1 Gene:mask-1 / 177927 WormBaseID:WBGene00011240 Length:2622 Species:Caenorhabditis elegans


Alignment Length:407 Identity:95/407 - (23%)
Similarity:168/407 - (41%) Gaps:117/407 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     4 RDHNNPQEGPTSSSGRRAAVE-------DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWT 61
            |.|:. .:|...:..|..|::       :..|.| |..|...|:|:.||:.|||:..:::: |::
 Worm  1211 RTHSE-GDGAERAKSRSNAIDKATETTLETPLTI-ACANGHKDIVELLLKEGANIEHRDKK-GFS 1272

Human    62 PL------------------HNAVQM----------------SREDIVELLLRHGADPVLRKKNG 92
            ||                  |.|::.                .|:|:|||||.|||:...|..:.
 Worm  1273 PLIIAATAGHSSVVEVLLKNHAAIEAQSDRTKDTALSLACSGGRKDVVELLLAHGANKEHRNVSD 1337

Human    93 ATPFILAAIAGSVKLLKLFLSKGADVNE--CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
            .||..||:..|.::::.:.|:.|:::|.  ....|.:..|.|::.|..:|.:.|.::|:::|.:.
 Worm  1338 YTPLSLASSGGYIEIVNMLLTAGSEINSRTGSKLGISPLMLASMNGHREATRVLLEKGSDINAQI 1402

Human   156 KTKEDQ------------------------ERLRKGGATALMDAAEKGHVEVLKILLDEMGADVN 196
            :|..:.                        |...|.|.|.||:.|..|:|:|..:|: ..|||.|
 Worm  1403 ETNRNTALTLASFQGRTEVVKLLLAYNANVEHRAKTGLTPLMECASGGYVDVGNLLI-AAGADTN 1466

Human   197 ACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE- 260
            |  :..:.....||..|.:...|....:||:..|.|:||.::|.|.|.||....:|...|.||| 
 Worm  1467 A--SPVQQTKDTALTISAEKGHEKFVRMLLNGDAAVDVRNKKGCTALWLACNGGYLSTAQALLEK 1529

Human   261 --------------------QEHIEI------------NDTDSDGKTALLLAVELKLKKIAELLC 293
                                :.|:||            |:.|.           ::.::.||...
 Worm  1530 GADPDMFDNRKISPMMAAFRKGHVEIVKYMVNSAKQFPNEQDL-----------IRAQQTAETDD 1583

Human   294 KRGASTDCGDLVMTARR 310
            .:....:|.|::.:|::
 Worm  1584 IKKKCGECIDIIRSAKK 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 4/16 (25%)
ANK repeat 24..56 CDD:293786 11/38 (29%)
ANK 1 24..53 11/35 (31%)
Ank_2 29..122 CDD:289560 34/128 (27%)
ANK 2 58..87 15/62 (24%)
ANK 59..188 CDD:238125 43/188 (23%)
ANK repeat 59..89 CDD:293786 15/63 (24%)
ANK repeat 91..122 CDD:293786 8/32 (25%)
ANK 3 91..120 7/28 (25%)
Ank_2 96..199 CDD:289560 31/128 (24%)
ANK repeat 124..154 CDD:293786 8/29 (28%)
ANK 4 124..153 7/28 (25%)
ANK repeat 167..199 CDD:293786 14/31 (45%)
ANK 5 167..197 12/29 (41%)
Ank_2 172..270 CDD:289560 36/130 (28%)
ANK 196..321 CDD:238125 32/148 (22%)
ANK repeat 201..236 CDD:293786 9/34 (26%)
ANK 6 201..234 8/32 (25%)
2-5A binding (P-loop) 1 229..242 5/12 (42%)
ANK 7 238..268 13/62 (21%)
Ank_2 243..326 CDD:289560 18/101 (18%)
2-5A binding (P-loop) 2 253..275 9/54 (17%)
ANK repeat 272..326 CDD:293786 5/39 (13%)
ANK 8 272..301 2/28 (7%)
ANK 9 303..329 2/8 (25%)
PKc_like 375..587 CDD:304357
Pkinase 387..586 CDD:278497
RNase_RNase-L 590..708 CDD:199218
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
mask-1NP_001263772.1 Ank_2 225..309 CDD:289560
ANK 257..382 CDD:238125
ANK repeat 257..288 CDD:293786
ANK repeat 290..323 CDD:293786
ANK repeat 325..349 CDD:293786
Ank_2 366..464 CDD:289560
ANK 402..528 CDD:238125
ANK repeat 405..433 CDD:293786
ANK repeat 440..468 CDD:293786
Ank_2 442..536 CDD:289560
ANK repeat 470..504 CDD:293786
ANK repeat 506..536 CDD:293786
ANK 572..688 CDD:238125
ANK repeat 572..599 CDD:293786
Ank_2 573..664 CDD:289560
ANK repeat 600..631 CDD:293786
ANK repeat 634..665 CDD:293786
ANK 1243..1357 CDD:238125 31/115 (27%)
Ank_2 1243..1334 CDD:289560 25/92 (27%)
ANK repeat 1269..1301 CDD:293786 5/32 (16%)
ANK 1301..1426 CDD:238125 28/124 (23%)
ANK repeat 1303..1334 CDD:293786 10/30 (33%)
Ank_2 1308..1401 CDD:289560 27/92 (29%)
ANK repeat 1336..1367 CDD:293786 8/30 (27%)
ANK repeat 1371..1401 CDD:293786 8/29 (28%)
Ank_2 1376..1467 CDD:289560 22/91 (24%)
ANK repeat 1404..1436 CDD:293786 2/31 (6%)
ANK 1434..1560 CDD:238125 38/128 (30%)
ANK repeat 1438..1467 CDD:293786 12/29 (41%)
Ank_2 1443..1537 CDD:289560 32/96 (33%)
ANK repeat 1475..1504 CDD:293786 9/28 (32%)
ANK repeat 1506..1537 CDD:293786 10/30 (33%)
ANK repeat 1539..1571 CDD:293786 4/31 (13%)
KH-I 1811..1875 CDD:238053
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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