DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and fem-1

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_500824.1	Gene:	fem-1 / 177335	WormBaseID:	WBGene00001411	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	699	Identity:	145/699 - (20%)
Similarity:	248/699 - (35%)	Gaps:	217/699 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    99 AAIAGSVKLLKLFLSKGAD----VNEC---DFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156
            ||..|:::.:|:|.....:    :.:|   |..|....:.||..|....:::|.:.||:.::|..
Worm    15 AAAVGNLQRIKVFTINSRNDRQWIIDCFNSDQDGRYPLVIAARNGHANVVEYLLEIGADPSVRGV 79

Human   157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAI 221
            .:.|.|.::  |...|..|:..||:|::|:|:::..||||...|.....|..|..   |..::.:
Worm    80 VEFDNENIQ--GTPPLWAASAAGHIEIVKLLIEKANADVNQATNTRSTPLRGACY---DGHLDIV 139

Human   222 THLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLK 286
            .: ||:.|||.::....|.|.|::|..:..:|:|:.|| :..|::|.....|.|||..|.|
Worm   140 KY-LLEKGADPHIPNRHGHTCLMIASYRNKVGIVEELL-KTGIDVNKKTERGNTALHDAAE---- 198

Human   287 KIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLH 351
                          .|::          .:||:||.||:                   ..:||:.
Worm   199 --------------SGNV----------EVVKILLKHGS-------------------VLMKDIQ 220

Human   352 RIYRPMIG-KLKFFIDEKYKIADTSEGGIY-------LG-------------------------- 382
            .: .|::| .|..|:|....:||....||:       ||
Worm   221 GV-DPLMGAALSGFLDVLNVLADQMPSGIHKRDALKLLGSTLLDKKMDAMSAMNCWKQSMEVPLH 284

Human   383 ------------FYEKQEV----------AVKTFCEGSPRAQREVSCLQSSR--ENSHLVTFYGS 423
                        |:|.|||          |.....:|:..|||..:.:...|  ..:|....|..
Worm   285 ADDLRLVREMETFFEPQEVYEYQREAQNIAQVELLDGNIEAQRMQALVIRERILGGAHTDVHYYL 349

Human   424 ESHRGHLFVCVTLCEQ-TLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL- 486
            . .||.::     |:. .:..|.|:.: ..:|.::..||.....:| ..:|..|.:...:..|.
Worm   350 R-FRGAVY-----CDMGQMNRCYDLWK-HALELQQKHFAPLYYGTI-TTLQSFHETFSMSLNDFV 406

Human   487 ----QPQNILIDSKKAAHL-----ADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDL 542
                ..:|:.:.|....::     .:.:::..|.|.|                       ..||.
Worm   407 NNHHANRNLRVRSSWVKYVFNGVCLELERAAAWTGAP-----------------------LLEDT 448

Human   543 KAQSNEEVVQLSPDEETKDLIH----------RLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLR 597
            :....|.....:.:.|.|.|::          ||..|..|:.|  ||....|     ::..|.|.
Worm   449 ECCGKERCQHATEESEYKKLVYVAVHLVNVLERLSLPSAHIDD--SDEEKEP-----KADVRRLM 506

Human   598 NVGNESDI---------KTRKSESEILRLLQPGPSEHSKSFD---KWTTKINECVM--------- 641
            .|.:|..|         :...|.|..|.|.:....|.....|   ..|.|.|:..|
Worm   507 IVCHELHIPLLHHTLEERIPDSNSAELGLPKAAVLEQLLELDLDVNATDKNNDTPMHILLRAREF 571

Human   642 -KKMNKFYEKRGN--FYQNTVGDL-------LKFIRN-------LGEHI 673
             |.:.:....||.  |.:|..||:       :|.:.:       ||.||
Worm   572 RKSLVRALLVRGTWLFARNRHGDVVLNVMKRMKALNHANFDDLPLGRHI 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786
		ANK 1	24..53
		Ank_2	29..122	CDD:289560	6/29 (21%)
		ANK 2	58..87
		ANK	59..188	CDD:238125	24/95 (25%)
		ANK repeat	59..89	CDD:293786
		ANK repeat	91..122	CDD:293786	6/29 (21%)
		ANK 3	91..120		5/24 (21%)
		Ank_2	96..199	CDD:289560	29/106 (27%)
		ANK repeat	124..154	CDD:293786	7/29 (24%)
		ANK 4	124..153		7/28 (25%)
		ANK repeat	167..199	CDD:293786	12/31 (39%)
		ANK 5	167..197		11/29 (38%)
		Ank_2	172..270	CDD:289560	30/97 (31%)
		ANK	196..321	CDD:238125	29/124 (23%)
		ANK repeat	201..236	CDD:293786	8/34 (24%)
		ANK 6	201..234		8/32 (25%)
		2-5A binding (P-loop) 1	229..242		4/12 (33%)
		ANK 7	238..268		9/29 (31%)
		Ank_2	243..326	CDD:289560	21/82 (26%)
		2-5A binding (P-loop) 2	253..275		7/21 (33%)
		ANK repeat	272..326	CDD:293786	13/53 (25%)
		ANK 8	272..301		6/28 (21%)
		ANK 9	303..329		6/25 (24%)
		PKc_like	375..587	CDD:304357	48/289 (17%)
		Pkinase	387..586	CDD:278497	42/231 (18%)
		RNase_RNase-L	590..708	CDD:199218	27/122 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
fem-1	NP_500824.1	ANK repeat	7..35	CDD:293786	5/19 (26%)
		Ank_2	12..118	CDD:289560	28/104 (27%)
		ANK repeat	47..86	CDD:293786	9/38 (24%)
		Ank	47..77	CDD:278452	7/29 (24%)
		ANK	83..209	CDD:238125	42/160 (26%)
		ANK repeat	92..120	CDD:293786	11/27 (41%)
		Ank_2	93..185	CDD:289560	30/96 (31%)
		ANK repeat	125..153	CDD:293786	8/31 (26%)
		ANK repeat	155..186	CDD:293786	10/31 (32%)
		ANK repeat	188..212	CDD:293786	11/51 (22%)
		Ank_4	189..240	CDD:290365	20/98 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000