DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNASEL and T28D6.4

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_499461.1	Gene:	T28D6.4 / 176566	WormBaseID:	WBGene00012124	Length:	991	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	130/461 - (28%)
Similarity:	196/461 - (42%)	Gaps:	96/461 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    17 SGRRAAVEDNHLLIKA---VQNED---------------VDLVQQLLEGGANVNFQEEEGGWTPL 63
            ||:.|||:   ||::.   |...|               .|:|..:::.||:||..::.|. |.|
Worm   501 SGQLAAVQ---LLLQTGAEVDRRDSEQRTALMAAAFMCHKDVVSVIIQYGADVNAIDKSGA-TAL 561

Human    64 H-----NAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDF 123
            |     .:.|....:..:|||.|.||..:...||.....|||..|. ..|:|.|.|...|:..|.
Worm   562 HLNLSNGSKQEENSETTKLLLEHNADCKIEDANGRVALHLAAYHGD-PCLQLILEKHPIVDVMDN 625

Human   124 YGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188
            .|.|..|.||..|:::|::||.|         ..|.|.:.:...|.|||..||..||.||::.|.
Worm   626 MGQTPLMLAASQGQLEAVQFLTK---------TAKADVDAIDNNGRTALQWAAINGHPEVVEFLC 681

Human   189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLG 253
             .:|:|....||.|..|| |..::.|  .||.:.||...|  .|..:...|:.|:::|....:|.
Worm   682 -SVGSDEGHKDNDGAVAL-HYAVTHD--HVELVKHLTNQH--TVEAKDRYGQHPMMIAAANGNLK 740

Human   254 LVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD----- 313
            :::.|:....| ||..|.:|:|||.||.......|.:|:..|  .||      .::|::|
Worm   741 VLEYLMGISDI-INQPDHEGRTALSLASMAAHTSIIDLISPR--ITD------WSQRDHDGTPLA 796

Human   314 HSLV--------KVLLSHGAK---EDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDE 367
            |:|:        :|.|.|||.   .|.|.........|::..||.|.|.|     ||.:.|
Worm   797 HTLILSNLIFVAEVYLGHGANSSDSDAHGRTCVHVVASTNDVAAAKMLKR-----IGGVNF---- 852

Human   368 KYKIADTSEGG---IYLGFYEKQEVAVKTF----CEGSP-RAQRE------VSCLQSSRENSHLV 418
                .....||   :....:.| .||:..|    |...| |..|:      ::.....|:..:|:
Worm   853 ----EAVDRGGRTALMTAVWAK-HVAISVFLLDSCGVDPNRTDRQGATALSIAAQIGDRDLVNLL 912

Human   419 TFYGSE 424
            ..:|:|
Worm   913 LKFGAE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		2/3 (67%)
		ANK repeat	24..56	CDD:293786	10/49 (20%)
		ANK 1	24..53		9/46 (20%)
		Ank_2	29..122	CDD:289560	31/115 (27%)
		ANK 2	58..87		11/33 (33%)
		ANK	59..188	CDD:238125	44/133 (33%)
		ANK repeat	59..89	CDD:293786	10/34 (29%)
		ANK repeat	91..122	CDD:293786	11/30 (37%)
		ANK 3	91..120		11/28 (39%)
		Ank_2	96..199	CDD:289560	35/102 (34%)
		ANK repeat	124..154	CDD:293786	10/29 (34%)
		ANK 4	124..153		10/28 (36%)
		ANK repeat	167..199	CDD:293786	13/31 (42%)
		ANK 5	167..197		13/29 (45%)
		Ank_2	172..270	CDD:289560	31/97 (32%)
		ANK	196..321	CDD:238125	38/137 (28%)
		ANK repeat	201..236	CDD:293786	11/34 (32%)
		ANK 6	201..234		11/32 (34%)
		2-5A binding (P-loop) 1	229..242		2/12 (17%)
		ANK 7	238..268		7/29 (24%)
		Ank_2	243..326	CDD:289560	26/95 (27%)
		2-5A binding (P-loop) 2	253..275		6/21 (29%)
		ANK repeat	272..326	CDD:293786	19/66 (29%)
		ANK 8	272..301		10/28 (36%)
		ANK 9	303..329		9/41 (22%)
		PKc_like	375..587	CDD:304357	14/64 (22%)
		Pkinase	387..586	CDD:278497	11/49 (22%)
		RNase_RNase-L	590..708	CDD:199218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
T28D6.4	NP_499461.1	Ank_2	428..521	CDD:372319	8/22 (36%)
		ANK repeat	428..454	CDD:293786
		ANK repeat	459..488	CDD:293786
		ANK repeat	490..521	CDD:293786	8/22 (36%)
		PHA03095	507..>776	CDD:222980	88/289 (30%)
		ANK repeat	523..554	CDD:293786	6/30 (20%)
		ANK repeat	556..592	CDD:293786	11/36 (31%)
		ANK repeat	594..624	CDD:293786	11/30 (37%)
		ANK repeat	626..658	CDD:293786	12/40 (30%)
		ANK repeat	660..691	CDD:293786	13/31 (42%)
		PHA03095	675..>943	CDD:222980	72/273 (26%)
		ANK repeat	725..756	CDD:293786	8/31 (26%)
		ANK repeat	824..856	CDD:293786	10/44 (23%)
		ANK repeat	858..890	CDD:293786	9/32 (28%)
		ANK repeat	892..923	CDD:293786	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000