DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and C18H2.5

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_741231.2	Gene:	C18H2.5 / 176082	WormBaseID:	WBGene00015992	Length:	1195	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	135/710 - (19%)
Similarity:	234/710 - (32%)	Gaps:	262/710 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   145 YKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI---LLDEMGAD--VNAC------ 198
            |||     :...|..|::.|                :.:||:   |:..:.:|  ||..
Worm   109 YKR-----IYESTNGDKDDL----------------LRILKLNEDLMTSVSSDYVVNKTKIHDFF 152

Human   199 DNMGRNALIHALLSSDDSDVEAITHL--LLDHGADVNVRGERGKTPLILAVEKK----------- 250
            |::|.|:.|..|...:::.||.|...  :::.....|   |..|...|:.::.:
Worm   153 DHLGNNSTISRLKGCNETHVEMIVEFWNVINEKKAAN---EDDKKIAIVTLKNRIPEVRQCMTSI 214

Human   251 -----------HLGLVQR----------LLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294
                       .:|.|.|          |.:::.||..:..:|.:         |||.||:.:.|
Worm   215 KEYYSFVYPISKVGEVFRNIFSARATVELFKKKQIEYENFPNDLE---------KLKNIAKKIIK 270

Human   295 RGASTDCG---DLVMTARRNYDHSLVKV------LLSHGAKEDFHPPAED----WKPQSSHWGAA 346
            ...:....   ::.||.:.:.|....|.      |:.:|..||.....||    |..:....|.:
Worm   271 DWEAPQVDVYKEVSMTVQLHKDMVQNKTMAVWLSLVGYGLIEDLKMVREDLNSVWFKEKVANGKS 335

Human   347 LKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSS 411
            :|.|.       ..|:.|    :|.::      |.|..|...:..|.|.    :|:|: :.|:|
Worm   336 IKFLE-------NSLEAF----FKFSE------YTGKLETTWIKFKAFF----KAERK-NLLES- 377

Human   412 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGED-VEN-------------EEDEFAR 462
                  ::||.|                 :..|.||..||. :||             :.::|||
Worm   378 ------LSFYSS-----------------INQCSDVASGEGAIENMKKIYNGCWKGSAQTEDFAR 419

Human   463 -----NVLSSIFKAVQELHLSCGYT--HQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRD 520
                 ..||.:...:.|:...|..|  ..|.......:||....:|.:.        :|||...:
Worm   420 FDEHSKTLSDLNSTIFEVLAWCNETVKQNDFDVMETALDSLNNLNLENL--------NPQETINE 476

Human   521 LEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHV------------ 573
            :.::.            :||||. ...|..::....::..|..::|.|....|
Worm   477 VREIQ------------NFEDLN-DFFERFLRFHLLQKKYDTDYQLLHKVNLVDVMEETAANLTK 528

Human   574 ------RDCL-------SDLLGHPFFWTWESRYRTLRNVGNESDIK------------------- 606
                  ..||       |.:.....|.|      ::|.:||.||.|
Worm   529 SKSIANLKCLKMKEFQSSKIHSTVEFIT------SVRRIGNSSDHKKIKDAVKIYSDMRTDYVAV 587

Human   607 ------TRKSESEILRLLQPGPSEHSKSFDKWTTKINE---CVMKKMNKFYEKRGNF-----YQN 657
                  ||:...:..:|.:..|....|...|..||:.:   | ::.:.:.|:.|...     |.|
Worm   588 EKFLEETRRQSKQNEQLTKQNPVLKFKHSMKIATKLAKGMIC-LRDLIESYKLRSEILNSANYDN 651

Human   658 TVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQ--NTEYRKH 715
            .|.|.:       .:.:|.|..| :...|.|..        |:.:|..:|.  |.|.||:
Worm   652 GVNDKI-------ANFNENKQVK-EFWSGSPGY--------LLEHVVRELDNLNMEARKY 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786
		ANK 1	24..53
		Ank_2	29..122	CDD:289560
		ANK 2	58..87
		ANK	59..188	CDD:238125	8/45 (18%)
		ANK repeat	59..89	CDD:293786
		ANK repeat	91..122	CDD:293786
		ANK 3	91..120
		Ank_2	96..199	CDD:289560	12/64 (19%)
		ANK repeat	124..154	CDD:293786	3/8 (38%)
		ANK 4	124..153		3/7 (43%)
		ANK repeat	167..199	CDD:293786	6/42 (14%)
		ANK 5	167..197		5/34 (15%)
		Ank_2	172..270	CDD:289560	24/142 (17%)
		ANK	196..321	CDD:238125	30/173 (17%)
		ANK repeat	201..236	CDD:293786	8/36 (22%)
		ANK 6	201..234		7/34 (21%)
		2-5A binding (P-loop) 1	229..242		3/12 (25%)
		ANK 7	238..268		8/61 (13%)
		Ank_2	243..326	CDD:289560	20/123 (16%)
		2-5A binding (P-loop) 2	253..275		7/31 (23%)
		ANK repeat	272..326	CDD:293786	13/62 (21%)
		ANK 8	272..301		7/28 (25%)
		ANK 9	303..329		7/31 (23%)
		PKc_like	375..587	CDD:304357	46/257 (18%)
		Pkinase	387..586	CDD:278497	43/244 (18%)
		RNase_RNase-L	590..708	CDD:199218	28/150 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741		0/1 (0%)
C18H2.5	NP_741231.2	WSN	40..108	CDD:197734
		Ank_4	856..909	CDD:290365
		ANK	860..>924	CDD:238125
		ANK repeat	860..886	CDD:293786
		ANK repeat	888..922	CDD:293786
		BRCT	964..1044	CDD:214602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900