DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and lido-18

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_001367413.1	Gene:	lido-18 / 176079	WormBaseID:	WBGene00015988	Length:	1199	Species:	Caenorhabditis elegans

Alignment Length:	495	Identity:	93/495 - (18%)
Similarity:	159/495 - (32%)	Gaps:	199/495 - (40%)

- Green bases have known domain annotations that are detailed below.

Human    24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
            :.|:.|:.|.|:.:...|.:.::.||.::...:.|. ||||.|.:....:|||:|:::|||..|.
Worm   859 DGNNALVDAAQDINATNVLKAVKKGAYIDVYSKYGN-TPLHVASKSGYPEIVEILIKNGADRTLL 922

Human    89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153
            .....|...|  |..:.|.        .|....:.|              :.:|.::|:......
Worm   923 NAQNKTAEQL--IPPNYKT--------TDPESIERY--------------EKIKLIFKKYQKKKF 963

Human   154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
            ||:               |.|...   |...||.:||     .|.|.|..:.:...:..:.|...
Worm   964 RRR---------------LPDVFP---VSSYKIYIDE-----QAIDQMSNSFMERFIAITTDETS 1005

Human   219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283
            .:|||.::                                         .||.:| |.:..|.:|
Worm  1006 LSITHFIV-----------------------------------------KTDENG-TLVTDAFQL 1028

Human   284 KLKKIAE--LLCKRGASTDC-GDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGA 345
             |..:..  |:.|.....|| |          :.||:        |:|::...|:.|.:.:.:..
Worm  1029 -LSWVLSGVLIMKNSWMKDCLG----------NESLI--------KKDYNYFVENIKFKGAVYNT 1074

Human   346 ALK-----------DLHRIYRPM-------IGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVK 392
            .|:           .||.:|..:       ||.:...:        |:.||:
Worm  1075 VLQWSESFAKGEMLFLHGVYAVVVSIDCSNIGAITAIV--------TNNGGV------------- 1118

Human   393 TFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGE-DVEN- 455
             .||..|           .::|.::.:.....:|.|.|||              :|.|: |::.
Worm  1119 -MCEKFP-----------EKKNFNIGSHPYLHAHLGPLFV--------------IHDGKVDLKTY 1157

Human   456 -----------EEDEFA---------RNVLSSIFKAVQEL 475
                       .||||.         ||...:...||.:|
Worm  1158 KNDPDKMYTLFTEDEFIHFMLKRKMNRNKSPNPIPAVNDL 1197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	7/31 (23%)
		ANK 1	24..53		7/28 (25%)
		Ank_2	29..122	CDD:289560	25/92 (27%)
		ANK 2	58..87		13/28 (46%)
		ANK	59..188	CDD:238125	28/128 (22%)
		ANK repeat	59..89	CDD:293786	13/29 (45%)
		ANK repeat	91..122	CDD:293786	5/30 (17%)
		ANK 3	91..120		5/28 (18%)
		Ank_2	96..199	CDD:289560	17/102 (17%)
		ANK repeat	124..154	CDD:293786	3/29 (10%)
		ANK 4	124..153		3/28 (11%)
		ANK repeat	167..199	CDD:293786	8/31 (26%)
		ANK 5	167..197		7/29 (24%)
		Ank_2	172..270	CDD:289560	14/97 (14%)
		ANK	196..321	CDD:238125	21/127 (17%)
		ANK repeat	201..236	CDD:293786	5/34 (15%)
		ANK 6	201..234		5/32 (16%)
		2-5A binding (P-loop) 1	229..242		0/12 (0%)
		ANK 7	238..268		0/29 (0%)
		Ank_2	243..326	CDD:289560	14/85 (16%)
		2-5A binding (P-loop) 2	253..275		3/21 (14%)
		ANK repeat	272..326	CDD:293786	12/56 (21%)
		ANK 8	272..301		7/30 (23%)
		ANK 9	303..329		3/25 (12%)
		PKc_like	375..587	CDD:304357	23/123 (19%)
		Pkinase	387..586	CDD:278497	21/111 (19%)
		RNase_RNase-L	590..708	CDD:199218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
lido-18	NP_001367413.1	WSN	40..107	CDD:197734
		Ank_2	835..918	CDD:403870	18/59 (31%)
		ANK repeat	859..890	CDD:293786	7/30 (23%)
		Ank	892..927	CDD:394980	14/35 (40%)
		ANK repeat	892..923	CDD:293786	14/31 (45%)
		BRCT	968..1048	CDD:214602	23/130 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900