DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNASEL and mel-11

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_001021928.1	Gene:	mel-11 / 174484	WormBaseID:	WBGene00003196	Length:	1124	Species:	Caenorhabditis elegans

Alignment Length:	657	Identity:	133/657 - (20%)
Similarity:	236/657 - (35%)	Gaps:	167/657 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
            :|:.:.:.|..:.|.:.|::||..|||:|....: |.|.||.:|..|:.::|..|...|||...:
Worm    54 QDSDIFLSACMSGDEEEVEELLNKGANINTCTVD-GLTALHQSVIDSKPEMVRFLCEKGADVNAQ 117

Human    89 KKNGATPFILAAIAGSVKLLKLFLSKGADVN----------------EC------DFYGFTAFME 131
            ...|.||...||..|:|.:::.....|||::                :|      |:......::
Worm   118 DNEGWTPLHAAACCGNVAIVRYLCQHGADLSIVNSDKELALDLAVDEQCRDYLDDDYKRQMIDLD 182

Human   132 AAVYGKVKALKFLYKRGANVNLRRKTKE--DQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD 194
            |.   :.:.|:.:.|   :||:.....|  |....|.|| ||:..||.:|:.::|::|: :.|.:
Worm   183 AC---RDQELQTMLK---DVNMWMSQGEYRDIPHHRTGG-TAMHVAAGRGYTQLLELLI-KAGGN 239

Human   195 VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLL 259
            |.|.|..|...| ||.....:.|.   ..:||::||:::.....|...|.:| :|:.:..:..|.
Worm   240 VRAQDVEGWTPL-HAAAHWAERDA---CKILLENGAELSDLTFTGADVLGVA-DKECIDYLVELA 299

Human   260 EQEHIEINDTDSDGK-----TALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYD------ 313
            :...:: |...|.|.     |::|.....::....|             .|:|:.|..|
Worm   300 DTVKVQ-NKRKSPGSGSQPPTSILQEKNHRMPSHEE-------------HVLTSERKRDLQHKDQ 350

Human   314 HSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGG 378
            ||..:.|.||              |.::..|:...                     ...:|:...
Worm   351 HSENEFLHSH--------------PSTASVGSTTS---------------------SNTNTTTTT 380

Human   379 IYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEA 443
            |.:|                   :.::|..|.....|...:....|.:         :.|..:|.
Worm   381 IVIG-------------------ENDISAAQKDSRESSKESAVDDEEY---------VAEDEMEE 417

Human   444 CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC-------------GYTHQDLQPQNILIDS 495
            ..:....||||.||:|.:...|.: .|.:..|....             |||.:....:....:.
Worm   418 AEEDEEEEDVEEEEEEKSEAELKN-GKEISPLRSETTSSRSISITRSLDGYTDRSSSGRETSAEM 481

Human   496 KKAAHLAD---FDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE 557
            .:||..|.   ...|.::.......:|.            ..||:..|..::.........|.|:
Worm   482 SEAASSASTGTTSSSSRFTSSTPSSQRS------------AAGSVHTETPRSSMENSSSVGSGDQ 534

Human   558 ETKDLIH--RLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP 620
            .....|.  .|..|.:.|....|         :|.:|...|.:..:.|.: ||.|.:.:..::.|
Worm   535 NVSATIPIVPLSAPPKAVHQSPS---------SWINRGVPLSSRSSTSSV-TRSSSTPVSEIISP 589

Human   621 GPSEHSK 627
            ..|.||:
Worm   590 PSSIHSQ 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	10/31 (32%)
		ANK 1	24..53		9/28 (32%)
		Ank_2	29..122	CDD:289560	31/114 (27%)
		ANK 2	58..87		11/28 (39%)
		ANK	59..188	CDD:238125	39/152 (26%)
		ANK repeat	59..89	CDD:293786	11/29 (38%)
		ANK repeat	91..122	CDD:293786	11/52 (21%)
		ANK 3	91..120		10/44 (23%)
		Ank_2	96..199	CDD:289560	29/126 (23%)
		ANK repeat	124..154	CDD:293786	5/29 (17%)
		ANK 4	124..153		4/28 (14%)
		ANK repeat	167..199	CDD:293786	12/31 (39%)
		ANK 5	167..197		11/29 (38%)
		Ank_2	172..270	CDD:289560	24/97 (25%)
		ANK	196..321	CDD:238125	28/135 (21%)
		ANK repeat	201..236	CDD:293786	9/34 (26%)
		ANK 6	201..234		9/32 (28%)
		2-5A binding (P-loop) 1	229..242		3/12 (25%)
		ANK 7	238..268		5/29 (17%)
		Ank_2	243..326	CDD:289560	19/93 (20%)
		2-5A binding (P-loop) 2	253..275		4/26 (15%)
		ANK repeat	272..326	CDD:293786	13/64 (20%)
		ANK 8	272..301		4/33 (12%)
		ANK 9	303..329		9/31 (29%)
		PKc_like	375..587	CDD:304357	36/229 (16%)
		Pkinase	387..586	CDD:278497	34/216 (16%)
		RNase_RNase-L	590..708	CDD:199218	10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
mel-11	NP_001021928.1	PHA03095	60..>280	CDD:222980	62/232 (27%)
		Ank_2	62..151	CDD:372319	30/89 (34%)
		ANK repeat	87..118	CDD:293786	11/31 (35%)
		ANK repeat	120..151	CDD:293786	10/30 (33%)
		ANK repeat	153..244	CDD:293786	22/98 (22%)
		ANK repeat	246..271	CDD:293786	7/28 (25%)
		ANK repeat	279..306	CDD:293786	5/28 (18%)
		PRKG1_interact	1011..1123	CDD:374206
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910