DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNASEL and rps6ka3

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	XP_031752603.1	Gene:	rps6ka3 / 100496161	XenbaseID:	XB-GENE-480947	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	702	Identity:	135/702 - (19%)
Similarity:	229/702 - (32%)	Gaps:	259/702 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    73 DIVELLLRH-------GADPVLRKKNGATPFILAAIAGSVKLLKLFLSK---GADVNECDFYGFT 127
            :|.|:.:.|       .|||        :.|.|..:.|.....|:||.:   |.|.
Frog    43 NINEIAITHHVKEGHEKADP--------SQFELLKVLGQGSFGKVFLVRKISGTDA--------- 90

Human   128 AFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLK------- 185
                    |::.|:|.|.|....|..|.:||.:::.|           .|..|..::|
Frog    91 --------GQLYAMKVLKKATLKVRDRVRTKMERDIL-----------VEVNHPFIVKLHYAFQT 136

Human   186 -----ILLDEM-GADVNACDNMGRNALIHALLSSD----DSDVE---AITHLLLDHGADVNVRGE 237
                 ::||.: |.|            :...||.:    :.||:   |...|.|||...:.:...
Frog   137 EGKLYLILDFLRGGD------------LFTRLSKEVMFTEEDVKYYLAELALALDHLHSLGIIYR 189

Human   238 RGKTPLILAVEKKHLGLVQRLLEQEHIE-------------------IN---DTDS--------- 271
            ..|...||..|:.|:.|....|.:|.|:                   :|   .|.|
Frog   190 DLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 254

Human   272 --------------DGKTALLLAVELKL----------KKIAELLCKRGASTDCG---DLVMTAR 309
                          |.|..:.:.::.||          :.:..:|.||..:...|   |.|...:
Frog   255 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLTPEAQSLLRMLFKRNPTNRLGAGPDGVEEIK 319

Human   310 RNYDHSLVKVL---------------LSHGAKED---FHPPAEDWKPQSSHWGAALKDLHRIYRP 356
            |   |.....:               .:.|..||   |.|......|:.|....|..:.|:::|
Frog   320 R---HPFFATIDWNKLYRRENQPPFKPATGGPEDTFYFDPEFTAKTPKDSPGIPASANAHQLFR- 380

Human   357 MIGKLKFFIDEKYKIADTSEG--------GIY-----------------------LGFYE----- 385
               ...|       :|.|||.        |::                       :|.|.
Frog   381 ---GFSF-------VAITSEDENQAMQTVGVHAIVPLHRNSIQFTDGYELKEDIGVGSYSICKRC 435

Human   386 -----KQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE--QTLEA 443
                 ..|.|||...:.......|:..|....::.:::|.........::::...|.:  :.|:.
Frog   436 IHKGTNMEYAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYLVTELMKGGELLDK 500

Human   444 CLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL-ID---SKKAAHLADF 504
            .|   |.:.....|   |..||.:|.|.|:.|| |....|:||:|.||| :|   :.::..:.||
Frog   501 IL---RQKFFSERE---ASAVLHTITKTVEYLH-SQWVVHRDLKPSNILYVDESGNPESIRICDF 558

Human   505 DKSIKWAGD---------------PQEVKR-------DLEDLGRLVLYVVKKGSISFEDLKAQSN 547
            ..:.:...:               |:.:||       |:..|| ::||.:..|...|.:....:.
Frog   559 GFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLG-VLLYTMLTGYTPFANGPDDTP 622

Human   548 EEVVQL--------------SPDEETKDLIHRLFHPGEHVRDCLSDLLGHPF 585
            ||::..              |..:..|||:.::.|...|.|...:.:|.||:
Frog   623 EEILARIGSGKFSLSGGYWNSVSDIAKDLVSKMLHVDPHQRLTAAQVLKHPW 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786
		ANK 1	24..53
		Ank_2	29..122	CDD:289560	14/58 (24%)
		ANK 2	58..87		6/20 (30%)
		ANK	59..188	CDD:238125	27/136 (20%)
		ANK repeat	59..89	CDD:293786	6/22 (27%)
		ANK repeat	91..122	CDD:293786	8/33 (24%)
		ANK 3	91..120		8/31 (26%)
		Ank_2	96..199	CDD:289560	25/118 (21%)
		ANK repeat	124..154	CDD:293786	6/29 (21%)
		ANK 4	124..153		6/28 (21%)
		ANK repeat	167..199	CDD:293786	7/44 (16%)
		ANK 5	167..197		7/42 (17%)
		Ank_2	172..270	CDD:289560	26/139 (19%)
		ANK	196..321	CDD:238125	33/204 (16%)
		ANK repeat	201..236	CDD:293786	9/41 (22%)
		ANK 6	201..234		9/39 (23%)
		2-5A binding (P-loop) 1	229..242		1/12 (8%)
		ANK 7	238..268		10/51 (20%)
		Ank_2	243..326	CDD:289560	24/155 (15%)
		2-5A binding (P-loop) 2	253..275		8/66 (12%)
		ANK repeat	272..326	CDD:293786	13/81 (16%)
		ANK 8	272..301		7/38 (18%)
		ANK 9	303..329		7/43 (16%)
		PKc_like	375..587	CDD:304357	58/294 (20%)
		Pkinase	387..586	CDD:278497	53/241 (22%)
		RNase_RNase-L	590..708	CDD:199218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
rps6ka3	XP_031752603.1	STKc_RSK_N	69..385	CDD:270734	67/369 (18%)
rps6ka3	XP_031752603.1	STKc_RSK2_C	399..737	CDD:271078	56/284 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910