DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNASEL and ankrd34a

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	XP_002938522.1	Gene:	ankrd34a / 100494120	XenbaseID:	XB-GENE-6035402	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	112/523 - (21%)
Similarity:	184/523 - (35%)	Gaps:	180/523 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEG---GWTPLHNAVQMSRED------IVELLLRHGAD 84
            |:|||......|.:.||||||.:|    ||   |.|||..|.....:|      :|:.||.:|||
Frog    14 LLKAVWQGKFRLTRLLLEGGAYIN----EGNAQGETPLMAACLAKYDDPQNKSRMVKYLLENGAD 74

Human    85 PVLRKKNGATPFILAA--IAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
            |.:..|.|.|..:.|.  :.|:. ::.:.|..|:|.:..|:
Frog    75 PNMPDKMGKTALMHACCNVTGAA-VVSVLLEHGSDPSIKDY------------------------ 114

Human   148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLS 212
                               .|.:|||.|..:|..|.|::|||       ||...|:..:|....:
Frog   115 -------------------SGTSALMYAINRGDRETLRVLLD-------ACKARGKEVIIITTDT 153

Human   213 S-------------------DD----------SDVEAITHLL----LDHGADV---NVRGERGKT 241
            |                   ||          ||:|..|.|.    .:...||   |: |.|...
Frog   154 SPSGTKKTKQYLNSPPSPGIDDKQSPGICMSPSDIEIKTSLSPASEKEEARDVFNFNM-GTRLTC 217

Human   242 PLILAVEKK---HLGLVQRLLEQEHIEINDTDSDGKTA-LLLA-----VELKLKKIAELLCKRGA 297
            |....:|.|   |:....|::.::.::..:::..|..| .:||     |..:...:.|  |:...
Frog   218 PSSSKLEVKPPDHIVAKGRMVNKKQLKRLNSEPWGLVAPSVLAGSHPTVPTENTTVEE--CEETI 280

Human   298 STDCGDLVMTAR---------RNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRI 353
            :|:..:|.::.|         ...|.|.:|:        |...|.:|.....:.|...::..| :
Frog   281 TTEVNNLSISNRPVLSRRHSIEGQDSSCLKL--------DEQSPGDDPSALDASWADKVQFSH-L 336

Human   354 YRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLV 418
            ::|:..:            :|:.        |.||.:..|.........|.|:..:.:|     :
Frog   337 HQPLSRR------------NTAP--------EAQETSNATLAPTIATNLRGVAHHKLTR-----M 376

Human   419 TFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEF-----------ARNVLSSIFKAV 472
            ..|.|:||         ||..::....|..|   |..|..::           :|..|.||..||
Frog   377 DHYESDSH---------LCPDSIPGSPDSGR---VSLERRKYNASPLTLFTSSSRESLESIPSAV 429

Human   473 QEL 475
            ..:
Frog   430 SPM 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	12/26 (46%)
		ANK 1	24..53		11/23 (48%)
		Ank_2	29..122	CDD:289560	35/103 (34%)
		ANK 2	58..87		14/37 (38%)
		ANK	59..188	CDD:238125	30/136 (22%)
		ANK repeat	59..89	CDD:293786	13/35 (37%)
		ANK repeat	91..122	CDD:293786	7/32 (22%)
		ANK 3	91..120		7/30 (23%)
		Ank_2	96..199	CDD:289560	18/104 (17%)
		ANK repeat	124..154	CDD:293786	0/29 (0%)
		ANK 4	124..153		0/28 (0%)
		ANK repeat	167..199	CDD:293786	12/31 (39%)
		ANK 5	167..197		11/29 (38%)
		Ank_2	172..270	CDD:289560	31/136 (23%)
		ANK	196..321	CDD:238125	35/178 (20%)
		ANK repeat	201..236	CDD:293786	13/70 (19%)
		ANK 6	201..234		12/68 (18%)
		2-5A binding (P-loop) 1	229..242		5/15 (33%)
		ANK 7	238..268		6/32 (19%)
		Ank_2	243..326	CDD:289560	17/100 (17%)
		2-5A binding (P-loop) 2	253..275		2/21 (10%)
		ANK repeat	272..326	CDD:293786	13/68 (19%)
		ANK 8	272..301		8/34 (24%)
		ANK 9	303..329		5/34 (15%)
		PKc_like	375..587	CDD:304357	23/112 (21%)
		Pkinase	387..586	CDD:278497	22/100 (22%)
		RNase_RNase-L	590..708	CDD:199218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
ankrd34a	XP_002938522.1	ANK	12..136	CDD:238125	44/169 (26%)
		ANK repeat	12..40	CDD:293786	13/29 (45%)
		Ank_2	14..113	CDD:289560	35/103 (34%)
		ANK repeat	42..79	CDD:293786	13/36 (36%)
		ANK repeat	81..113	CDD:293786	7/32 (22%)
		Ank_2	86..>145	CDD:289560	20/109 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910