DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RNASEL and sik3

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:XP_004916140.2 Gene:sik3 / 100492939 XenbaseID:XB-GENE-6042192 Length:1284 Species:Xenopus tropicalis


Alignment Length:403 Identity:88/403 - (21%)
Similarity:145/403 - (35%) Gaps:103/403 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   360 KLKFFIDEKYKIADTSEGGIYLGFYEKQEVAV-KTFCEGSPRAQREVSCLQSSRENSHLVTFYGS 423
            |:...|.:|.|:.:.:...|:      :||.: |..|.  |...|....:::.| ..:|||.|.|
 Frog    51 KVAIKIIDKTKLDEENLKKIF------REVQIMKMLCH--PHIIRLYQVMETER-MIYLVTEYAS 106

Human   424 ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSC-GYTHQDLQ 487
               .|.:|..:            |..|...|.|    ||.....|..||...|  | ...|:||:
 Frog   107 ---GGEIFDHL------------VAHGRMAEKE----ARKKFKQIVAAVHFCH--CRNIVHRDLK 150

Human   488 PQNILIDSKKAAHLADFDKSIK---------WAGDPQEV-------------KRDLEDLGRLVLY 530
            .:|:|:|:.....:|||..|.:         |.|.|...             |.|:..|| :|||
 Frog   151 AENLLLDANLNIKIADFGFSNRFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLG-VVLY 214

Human   531 VVKKGSISF-----EDLKAQ--SNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT 588
            |:..|::.|     ::|:|:  |.:..:......|.:.||..:.......|..:..:..|.:...
 Frog   215 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLEPSKRLSMEQICKHKWMCQ 279

Human   589 WESRYRTLRNVGNESDIKTRK-----SESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFY 648
            .|......|.:.....:|..:     :|..:|.:::.|       .|:..|     :.......|
 Frog   280 GEQDLEFERLIAECQHVKLERQRDPLNEQVLLTMVEMG-------LDRERT-----LQSLRTDAY 332

Human   649 EKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYR 713
            :.....| :.:.|.||            :||.::|    |:   |.:.|..|.|....:|    .
 Frog   333 DHYSAIY-SLLCDRLK------------RHKTLRL----PT---QPSAPRTVSYSTPSVQ----A 373

Human   714 KHFPQTHSPNKPQ 726
            .....|.|.|.||
 Frog   374 DAASNTVSINVPQ 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786
ANK 1 24..53
Ank_2 29..122 CDD:289560
ANK 2 58..87
ANK 59..188 CDD:238125
ANK repeat 59..89 CDD:293786
ANK repeat 91..122 CDD:293786
ANK 3 91..120
Ank_2 96..199 CDD:289560
ANK repeat 124..154 CDD:293786
ANK 4 124..153
ANK repeat 167..199 CDD:293786
ANK 5 167..197
Ank_2 172..270 CDD:289560
ANK 196..321 CDD:238125
ANK repeat 201..236 CDD:293786
ANK 6 201..234
2-5A binding (P-loop) 1 229..242
ANK 7 238..268
Ank_2 243..326 CDD:289560
2-5A binding (P-loop) 2 253..275
ANK repeat 272..326 CDD:293786
ANK 8 272..301
ANK 9 303..329
PKc_like 375..587 CDD:304357 57/242 (24%)
Pkinase 387..586 CDD:278497 56/229 (24%)
RNase_RNase-L 590..708 CDD:199218 21/122 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741 5/12 (42%)
sik3XP_004916140.2 STKc_SIK 25..277 CDD:270973 61/256 (24%)
UBA_SIK3 306..350 CDD:270593 10/68 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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