DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and invs

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	XP_002939636.1	Gene:	invs / 100487895	XenbaseID:	XB-GENE-1221137	Length:	1004	Species:	Xenopus tropicalis

Alignment Length:	698	Identity:	163/698 - (23%)
Similarity:	250/698 - (35%)	Gaps:	215/698 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    44 LLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKK---NGATPFILAAIAGSV 105
            |||...:.|...:..|.||||.|.|.:..|.|.:||.|   |.:|.:   .|.|.|:.||..||.
Frog   270 LLERNNSPNIPSDSQGATPLHYAAQGNCPDTVRVLLSH---PSVRDEADLEGRTAFMWAAGKGSD 331

Human   106 KLLK--LFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG 168
            ::::  |.|....:||..|.||.||...|::.|::..::.|.:.||.|:.....|.
Frog   332 EVVRTMLELDHELEVNRTDKYGGTALHAASLSGQITTVRILLENGAQVDAVDVMKH--------- 387

Human   169 ATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVN 233
             |.|..|.|.||.||:..|: :.||.|:..|..||:.|..|.|..:.:    :..:|:::..:.:
Frog   388 -TPLFRACEMGHREVIATLV-KGGAKVHLVDKDGRSPLHWAALGGNAN----VCQILIENNINPD 446

Human   234 VRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL--------LLAVELKLKKIAE 290
            .:...|:|||..|....::|.::.|:|.: .:.|..|.:|:|||        |.||:|.|
Frog   447 AQDYEGRTPLQCAAYGGYIGCMEVLMENK-ADPNIQDKNGRTALHWSCNNGYLDAVKLLL----- 505

Human   291 LLCKRGASTDCGDLVMTARR--NYDHSL-------VKVLLSHGAKEDFHPPAEDWKPQSSHWGAA 346
                 |.|.....:..|..|  ..|::|       ::.:|.|||...                ||
Frog   506 -----GYSAFPNQMENTEERYTPLDYALLGGHQEVIQFMLEHGALSI----------------AA 549

Human   347 LKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLG------FYEKQEVAVK--TFCEGSPRAQR 403
            ::|                     ||.:....:|.|      |.|::.:.:|  ...:|:...:|
Frog   550 IQD---------------------IAASKIQAVYKGHKVRRAFQERKNLLMKHEQLRKGAAAKKR 593

Human   404 EVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLD-------------VH--RGEDV 453
            |       .:|.|.|.            |..|.|:|..|..::             ||  .||.|
Frog   594 E-------GDNRHKVR------------VGQTECKQRDENLMERQNKSNQQITNEIVHEWHGEAV 639

Human   454 ENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVK 518
            .|.||.                  .|     |.|..|..|:.|   ||...:::.|..|
Frog   640 GNSEDR------------------EC-----DHQVDNKNIEPK---HLKHLEQNSKPTG------ 672

Human   519 RDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDE-ETKDLIHRLFHPGEHVRDCLSDLLG 582
                                    |.|.....||.||.| |..:.:.....| ....:..|..||
Frog   673 ------------------------KNQRRTACVQSSPPENENINSVQTRISP-SGTSNAQSSSLG 712

Human   583 H--PFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMN 645
            :  |....|:.         |.|...|:.......|:..|....|         :|.:.:.|:..
Frog   713 NETPIEMNWDD---------NPSHKHTQNRRISRHRMESPDVVVH---------RIEDLIQKESR 759

Human   646 K---FYEKRGNFYQNTVGD--LLKFIRNLGEHI--DEEKHKKMKLKIG 686
            |   ..|::|:..|....|  |....|.....:  .||:.||...|.|
Frog   760 KKSHREERKGSHRQRESSDNRLCVSERETSNSVIQTEEERKKKGTKKG 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	4/11 (36%)
		ANK 1	24..53		3/8 (38%)
		Ank_2	29..122	CDD:289560	29/82 (35%)
		ANK 2	58..87		13/28 (46%)
		ANK	59..188	CDD:238125	45/133 (34%)
		ANK repeat	59..89	CDD:293786	13/29 (45%)
		ANK repeat	91..122	CDD:293786	11/32 (34%)
		ANK 3	91..120		10/30 (33%)
		Ank_2	96..199	CDD:289560	33/104 (32%)
		ANK repeat	124..154	CDD:293786	10/29 (34%)
		ANK 4	124..153		10/28 (36%)
		ANK repeat	167..199	CDD:293786	12/31 (39%)
		ANK 5	167..197		12/29 (41%)
		Ank_2	172..270	CDD:289560	27/97 (28%)
		ANK	196..321	CDD:238125	32/141 (23%)
		ANK repeat	201..236	CDD:293786	6/34 (18%)
		ANK 6	201..234		6/32 (19%)
		2-5A binding (P-loop) 1	229..242		1/12 (8%)
		ANK 7	238..268		8/29 (28%)
		Ank_2	243..326	CDD:289560	25/99 (25%)
		2-5A binding (P-loop) 2	253..275		6/21 (29%)
		ANK repeat	272..326	CDD:293786	18/70 (26%)
		ANK 8	272..301		11/36 (31%)
		ANK 9	303..329		8/34 (24%)
		PKc_like	375..587	CDD:304357	47/237 (20%)
		Pkinase	387..586	CDD:278497	43/218 (20%)
		RNase_RNase-L	590..708	CDD:199218	21/104 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
invs	XP_002939636.1	ANKYR	<2..135	CDD:223738
		ANK repeat	12..41	CDD:293786
		ANK repeat	44..74	CDD:293786
		ANK repeat	76..142	CDD:293786
		ANK repeat	146..175	CDD:293786
		PHA03095	161..>456	CDD:222980	62/203 (31%)
		ANK repeat	177..214	CDD:293786
		ANK repeat	216..248	CDD:293786
		ANK repeat	250..282	CDD:293786	4/11 (36%)
		ANK repeat	284..312	CDD:293786	13/30 (43%)
		ANK repeat	317..344	CDD:293786	9/26 (35%)
		ANK repeat	352..383	CDD:293786	10/30 (33%)
		ANK repeat	385..416	CDD:293786	13/41 (32%)
		ANK repeat	418..449	CDD:293786	6/34 (18%)
		Ank_2	423..513	CDD:372319	25/104 (24%)
		ANK repeat	451..482	CDD:293786	9/31 (29%)
		ANK repeat	484..512	CDD:293786	11/37 (30%)
		Ank_2	489..>565	CDD:372319	22/122 (18%)
		ANK repeat	517..544	CDD:293786	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910