DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNASEL and epha7

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	XP_031758138.1	Gene:	epha7 / 100486526	XenbaseID:	XB-GENE-488635	Length:	1062	Species:	Xenopus tropicalis

Alignment Length:	339	Identity:	72/339 - (21%)
Similarity:	101/339 - (29%)	Gaps:	118/339 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   381 LGFYEKQEVAVKTF-CEGSPRAQ----------------REVSCLQSSRENSHLVTFYGSESHRG 428
            :|:.|||.   :.| ||.|...|                :.|..:....||..|..|...:..:|
Frog   689 VGYTEKQR---RDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRQQQKKG 750

Human   429 H---------------------LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAV 472
            .                     .||.|    |||..     .|.:.:..:.:|....|..:.:.:
Frog   751 KNCLEWFTSPPKSKRSGSTQTMPFVKV----QTLNT-----PGTNAQKLDGQFTVIQLVGMLRGI 806

Human   473 ---QELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKK 534
               .......||.|:||..:|||::|.....::||..|.....||..|            |....
Frog   807 AAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRIIEDDPDAV------------YTTTG 859

Human   535 GSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWT-----WESRYR 594
            |.|...    .:..|.:|           :|.|.....|             |:     ||....
Frog   860 GKIPVR----WTAPEAIQ-----------YRKFTSASDV-------------WSYGIVMWEVMSY 896

Human   595 TLRNVGNESDIKTRKSESEILRLLQPGPSE-----HSKSFDKWTTKINECVMKKMNKFYEKRGNF 654
            ..|...:.|:....|:..|..||  |.|.:     |....|.|..:..|            |..|
Frog   897 GERPYWDMSNQDVIKAIEEGYRL--PAPMDCPAGLHQLMLDCWQKERGE------------RPKF 947

Human   655 YQNTVGDLLKFIRN 668
            .| .||.|.|.|||
Frog   948 EQ-IVGILDKMIRN 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786
		ANK 1	24..53
		Ank_2	29..122	CDD:289560
		ANK 2	58..87
		ANK	59..188	CDD:238125
		ANK repeat	59..89	CDD:293786
		ANK repeat	91..122	CDD:293786
		ANK 3	91..120
		Ank_2	96..199	CDD:289560
		ANK repeat	124..154	CDD:293786
		ANK 4	124..153
		ANK repeat	167..199	CDD:293786
		ANK 5	167..197
		Ank_2	172..270	CDD:289560
		ANK	196..321	CDD:238125
		ANK repeat	201..236	CDD:293786
		ANK 6	201..234
		2-5A binding (P-loop) 1	229..242
		ANK 7	238..268
		Ank_2	243..326	CDD:289560
		2-5A binding (P-loop) 2	253..275
		ANK repeat	272..326	CDD:293786
		ANK 8	272..301
		ANK 9	303..329
		PKc_like	375..587	CDD:304357	47/246 (19%)
		Pkinase	387..586	CDD:278497	44/239 (18%)
		RNase_RNase-L	590..708	CDD:199218	23/84 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
epha7	XP_031758138.1	EphR_LBD_A7	29..205	CDD:198453
		Ephrin_rec_like	274..311	CDD:400166
		FN3	331..420	CDD:214495
		FN3	468..559	CDD:238020
		EphA2_TM	585..650	CDD:405290
		PTKc_EphR_A	648..958	CDD:270651	69/335 (21%)
		SAM_EPH-A7	983..1052	CDD:188947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910