DRSC/TRiP Functional Genomics Resources

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Protein Alignment RNASEL and LOC100485259

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:XP_002933099.1 Gene:LOC100485259 / 100485259 -ID:- Length:605 Species:Xenopus tropicalis


Alignment Length:444 Identity:92/444 - (20%)
Similarity:145/444 - (32%) Gaps:151/444 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   313 DHSLVKVLLSHGAKEDFH------PPAEDW-KPQSSH----------WGAALKDLHRIYRPMIGK 360
            ||.::|   .|..:...|      ||.  | ....||          .||..|..|         
 Frog    10 DHGVIK---GHTGRRKEHGTGAGSPPM--WHSADGSHIISDPGRGAPHGAVKKHHH--------- 60

Human   361 LKFFIDEKYKIADTSEGGIYLGFYEKQE------VAVKTFCEGS-------PRAQREV---SCLQ 409
             |..|..:|::.:|...|.|.......|      ||||:..:..       ...|||:   :.||
 Frog    61 -KHSIKHRYELLETLGRGTYGKVKRATEKATGKMVAVKSIQKDKITDERDRVHLQREIEITALLQ 124

Human   410 -----------SSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARN 463
                       .||:...:|..|.|   .|.|:..:.            ::.:..||:...|.|.
 Frog   125 HEHIIRVFEVFESRDKIIIVMEYAS---NGELYDFIN------------NKHQIPENDARRFFRQ 174

Human   464 VLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWAGDP----Q 515
            ::|    ||...|.. |..|:|::.:|||:|......||||..|         ..:.|.|    .
 Frog   175 IVS----AVHYCHKK-GIVHRDIKLENILLDDNLNVKLADFGLSNHFQKHQVLETYCGSPLYASP 234

Human   516 EVKRDLEDLG--------RLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETK------DLIHRL 566
            |:.:.|...|        .::||.:..|.:.||:...:|..|.:......|..      .|:..:
 Frog   235 EIVKGLPYQGPEVDCWALGVLLYALVYGIMPFENSNYKSLAEQISRGQYREPPHLSGAFGLVDWM 299

Human   567 FHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDK 631
            .......|..:.|:..|  :|.         |.|.::.:    .:.|:      .|..||....:
 Frog   300 LTVNTSSRATIEDIANH--WWV---------NWGYDTVV----CDCEL------APECHSPLLAR 343

Human   632 WTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKI 685
            :.    ||                |||.|    |.....||..:|..|:.:.::
 Frog   344 YI----EC----------------QNTQG----FQMTTMEHQQDELRKEEEYEV 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786
ANK 1 24..53
Ank_2 29..122 CDD:289560
ANK 2 58..87
ANK 59..188 CDD:238125
ANK repeat 59..89 CDD:293786
ANK repeat 91..122 CDD:293786
ANK 3 91..120
Ank_2 96..199 CDD:289560
ANK repeat 124..154 CDD:293786
ANK 4 124..153
ANK repeat 167..199 CDD:293786
ANK 5 167..197
Ank_2 172..270 CDD:289560
ANK 196..321 CDD:238125 3/7 (43%)
ANK repeat 201..236 CDD:293786
ANK 6 201..234
2-5A binding (P-loop) 1 229..242
ANK 7 238..268
Ank_2 243..326 CDD:289560 4/12 (33%)
2-5A binding (P-loop) 2 253..275
ANK repeat 272..326 CDD:293786 4/12 (33%)
ANK 8 272..301
ANK 9 303..329 4/15 (27%)
PKc_like 375..587 CDD:304357 56/265 (21%)
Pkinase 387..586 CDD:278497 54/252 (21%)
RNase_RNase-L 590..708 CDD:199218 17/96 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
LOC100485259XP_002933099.1 STKc_NUAK 67..319 CDD:270975 58/273 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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