DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNASEL and LOC100334396

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	XP_021333736.1	Gene:	LOC100334396 / 100334396	-ID:	-	Length:	888	Species:	Danio rerio

Alignment Length:	892	Identity:	200/892 - (22%)
Similarity:	338/892 - (37%)	Gaps:	254/892 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    29 LIKAVQNEDVDLVQQLLEGGANVN--FQEEEGGW----TPLHNAVQMSREDIVELLLRHGADPVL 87
            |||.::....:.::::|. |.::|  :..||  |    |.|..||..::|:|...||...|||..
Zfish    16 LIKCIKENKQERLRKVLR-GRDINGLYPSEE--WNDDVTLLTAAVFWTKEEICTYLLGESADPNK 77

Human    88 RKKNGATPFILAAIAGSVKL--LKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA- 149
            :..||.||...||....|.|  :|..|:..||.|......||....|...|:...:|.|.:.||
Zfish    78 QSTNGHTPLHYAAFTAGVPLSIVKRLLAAKADPNGHRLLIFTPLQCAVDNGREDIVKALIEAGAS 142

Human   150 -------NVNLRRKTK----------EDQERLRKGGATALMDAAEKGHVEV-------------- 183
                   |.::.:|.:          |:.:::.:..:| ..|...|...||
Zfish   143 PERNHGKNPDVDKKVERMISEISSHNEEFKKVHQFFST-FCDILPKKPTEVHRIYKEHFLQEQPF 206

Human   184 ------------------------LKILLDEMGAD------VNACDNMGRNALIH---------- 208
                                    :|.|.|...||      :.....:.:...:|
Zfish   207 MHINLFEMYFGPFGLGDEQYRQSAIKWLKDTKSADRYIEGAIKRFPKISQEYCVHLLTCLSFALC 271

Human   209 -------------------ALLSSDDSDVEAITHLLL---------------DHGADVNVRGERG 239
                               :|...:::..|.|.||:|               :|..     .|:.
Zfish   272 VSESVSPQVFSELVPILTNSLQPFENTQGELINHLVLKILNVMMQKTSEQRQNHSV-----YEKL 331

Human   240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD-----------------GKTALLLAVELKLKK 287
            ...|:......:..|::.:.....:.:||...:                 .:|.:..|::.||:|
Zfish   332 SKSLLPLTHSNYSSLIRLMTYGLFVYLNDFAPELVALSGLSPVPETVLLKAETGMDEAMKKKLQK 396

Human   288 I------------AELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKE----DFHPP---- 332
            :            .|.||:..|:      :.|.|:.......||....|::|    |...|
Zfish   397 LDESLRHPVGSSAVESLCEETAA------LSTRRKKRRRKKKKVNQEAGSQETELQDKEQPYAVE 455

Human   333 -------------------AEDWKPQSSHWGAALK-----DLHRIYRPMIGKLKFFIDEKYKIAD 373
                               ...|...|..|...|:     |::.|:|  :..|...:|.::.||:
Zfish   456 ASIEESNSSVQPFIQSTVMPRKWHKISHRWRPKLEKLANMDINNIHR--LPSLTLVLDPEFLIAN 518

Human   374 TSEG-GIYLGFYEK-QEVAVKTFCEGSPRA-QREVSCLQ-SSRENSHLVTF--YGSESHRGHLFV 432
            .|:| .::||..:. .|||||...:.:.:. :.|...|: ...|:..:|.:  :..:.|.|:|
Zfish   519 GSDGTQVFLGLRDDGTEVAVKRMVKFNYQVLKNEEEFLRLPELESQSIVRYVDFAEDDHFGYL-- 581

Human   433 CVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH-LSCGYTHQDLQPQNILIDSK 496
            .:.|||.|||..:..|..|| ::|.......::..:..::|.|| ......|:|::|||:|||.:
Zfish   582 VLQLCEYTLEEYIQDHLPED-KDERTLVLEKLVKEVLCSLQVLHDPQTKVLHRDIKPQNVLIDIQ 645

Human   497 KAAHLADFDKSIK-----------------WAGDPQEVKR---------DLEDLGRLVLYVVKKG 535
            ..|.||||..|.:                 |.......|:         |::..|.||.|::..|
Zfish   646 GKARLADFGISRRLKQGETTLQTSIAGTRCWKAKESINKKINTGYKRSSDIQVAGMLVYYILSGG 710

Human   536 SISF-EDLKAQSN----EEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRT 595
            ...| ||:..:.|    ...::...|:..|||:..:.....:.|..:...|.||||||.|.:.|.
Zfish   711 HHPFGEDVDCEGNILRGRYSLEHLDDDLAKDLVEWMIDGNPNKRPTVEQSLAHPFFWTDERKVRY 775

Human   596 LRNVGNESDI-KTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTV 659
            |:.:|:|::. |.||:..|::..:  ......|||.:|.:|....:::::.|   |||.:.:|.:
Zfish   776 LKILGSENEAEKNRKANKELIDAI--SKCTEGKSFAEWKSKFPSELVQELEK---KRGAYPENML 835

Human   660 GDLLKFIRNL-GEH-IDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVY 704
            | ||:||||| |.| .|..|:..:.|            ||||.:.||
Zfish   836 G-LLRFIRNLYGHHKADAAKNSPLVL------------FPDLFVSVY 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	6/28 (21%)
		ANK 1	24..53		6/25 (24%)
		Ank_2	29..122	CDD:289560	33/100 (33%)
		ANK 2	58..87		12/32 (38%)
		ANK	59..188	CDD:238125	42/190 (22%)
		ANK repeat	59..89	CDD:293786	12/33 (36%)
		ANK repeat	91..122	CDD:293786	13/32 (41%)
		ANK 3	91..120		12/30 (40%)
		Ank_2	96..199	CDD:289560	30/166 (18%)
		ANK repeat	124..154	CDD:293786	9/37 (24%)
		ANK 4	124..153		9/36 (25%)
		ANK repeat	167..199	CDD:293786	10/75 (13%)
		ANK 5	167..197		10/73 (14%)
		Ank_2	172..270	CDD:289560	22/185 (12%)
		ANK	196..321	CDD:238125	26/197 (13%)
		ANK repeat	201..236	CDD:293786	8/78 (10%)
		ANK 6	201..234		8/76 (11%)
		2-5A binding (P-loop) 1	229..242		1/12 (8%)
		ANK 7	238..268		2/29 (7%)
		Ank_2	243..326	CDD:289560	18/111 (16%)
		2-5A binding (P-loop) 2	253..275		3/38 (8%)
		ANK repeat	272..326	CDD:293786	14/82 (17%)
		ANK 8	272..301		9/57 (16%)
		ANK 9	303..329		6/29 (21%)
		PKc_like	375..587	CDD:304357	64/249 (26%)
		Pkinase	387..586	CDD:278497	59/234 (25%)
		RNase_RNase-L	590..708	CDD:199218	38/118 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
LOC100334396	XP_021333736.1	ANK	47..151	CDD:238125	32/103 (31%)
		ANK repeat	81..111	CDD:293786	12/29 (41%)
		ANK repeat	112..145	CDD:293786	8/32 (25%)
		PKc_like	508..767	CDD:328722	67/261 (26%)
		RNase_Ire1_like	770..870	CDD:326562	38/118 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I12032
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0013115
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960