DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and slk

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	XP_031762309.1	Gene:	slk / 100145483	XenbaseID:	XB-GENE-877088	Length:	1338	Species:	Xenopus tropicalis

Alignment Length:	776	Identity:	137/776 - (17%)
Similarity:	243/776 - (31%)	Gaps:	332/776 - (42%)

- Green bases have known domain annotations that are detailed below.

Human     9 PQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMS--- 70
            |.||.........:.|.|    |.:.:.:||::.::.:..:::|...|:.    ..|.|.:|
Frog   749 PSEGDAQVMNSEESKETN----KDIHDNNVDVLNKIPDSVSHLNTDLEQS----CDNTVNVSVAA 805

Human    71 ---------REDIVELLLRHGADPVLRKKNGATPFILAAIA--------------------GSVK 106
                     |:..|..:....||   :|:|  |..|..|.|                    ||:.
Frog   806 ESSSATVHERQPCVPSISVISAD---QKEN--TSSISTAEASKSEPEHTDSDSGMGSTNDSGSMD 865

Human   107 L---LKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG 168
            |   :..|||||.:                            ....:|...|:.|:..::.||
Frog   866 LNLSISSFLSKGKE----------------------------SGSLSVQDNRRQKKTLKKTRK-- 900

Human   169 ATALMDAAEKGHVEVLKILLDEMGADVNACDN-------MGRNAL--IHALLSSDDSDVEAITHL 224
              .::|..|.. |...||:.|.        |:       :.|..|  :..|...:....:.:::.
Frog   901 --FIVDGVEVS-VTTSKIVTDN--------DSKSEEMRFLRRQELRELRLLQKEEQRAQQLLSNK 954

Human   225 LLDHGADVNVRGERGKTPL-------ILAVEKKHLGLVQRLLEQEHIE----------------- 265
            ||.....:..|.|:..|..       |..:||:....::| |||||..
Frog   955 LLQQREQIFKRFEQEMTSKKRQYDQDIENLEKQQKQTIER-LEQEHTTRLRDEAKRIKGEQDKEY 1018

Human   266 --------------INDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSL 316
                          ||:.:   |.|..|..||..:|..||...:.|...  :.|...::..|.||
Frog  1019 SKFQNVLKNRKKEVINEVE---KAAKELRKELMKRKKEELAQSQHAQEQ--EFVQKQQQELDGSL 1078

Human   317 VKVL--------------LSH-----GAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLK 362
            .|::              |:|     .|:|     |..|:.:..|    |::.|::       ||
Frog  1079 KKIIHQQKTELANIERDCLNHKQQLMRARE-----AAIWELEERH----LQEKHQL-------LK 1127

Human   363 FFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHR 427
            ..:.::|             |.::.::.        .|.::|:.  |..|.|..|:
Frog  1128 QQLKDQY-------------FMQRHQLL--------KRHEKEME--QMQRYNQRLI--------- 1160

Human   428 GHLFVCVTLCEQTLEACLDVHRGEDVENEE-DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNI 491
                                   |:::|.: .|.||  |..|.::
Frog  1161 -----------------------EELKNRQTQERAR--LPKIQRS-------------------- 1180

Human   492 LIDSKKAAHLADFDKS--IKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLS 554
              |:|  ..:|.|.||  |..:|.|::.:..::..|             .::.|.|.||.:.|..
Frog  1181 --DAK--TRMAMFKKSLRINSSGSPEQDREKIKQFG-------------LQEDKRQKNERLAQHQ 1228

Human   555 PDE-ETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLL 618
            ..| :.:||          ...|             ::..|.|:.:.||......:.|::.|:.|
Frog  1229 KHENQMRDL----------QLQC-------------DANVRELQQLQNEKCHLLIEHETQKLKEL 1270

Human   619 QPGPSEHSKSFDKWTTKI---------------------------NECV----MKKMNKFY 648
            .   .||:....:|..|:                           :||:    ..:::|||
Frog  1271 D---EEHAVELKEWREKLRPRKKALEEEFARKLQEQEVFFKMSGESECLNPTTQSRISKFY 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/11 (27%)
		ANK repeat	24..56	CDD:293786	6/31 (19%)
		ANK 1	24..53		5/28 (18%)
		Ank_2	29..122	CDD:289560	26/127 (20%)
		ANK 2	58..87		7/40 (18%)
		ANK	59..188	CDD:238125	31/163 (19%)
		ANK repeat	59..89	CDD:293786	7/41 (17%)
		ANK repeat	91..122	CDD:293786	13/53 (25%)
		ANK 3	91..120		13/51 (25%)
		Ank_2	96..199	CDD:289560	22/125 (18%)
		ANK repeat	124..154	CDD:293786	1/29 (3%)
		ANK 4	124..153		1/28 (4%)
		ANK repeat	167..199	CDD:293786	6/31 (19%)
		ANK 5	167..197		6/29 (21%)
		Ank_2	172..270	CDD:289560	26/144 (18%)
		ANK	196..321	CDD:238125	34/185 (18%)
		ANK repeat	201..236	CDD:293786	5/36 (14%)
		ANK 6	201..234		5/34 (15%)
		2-5A binding (P-loop) 1	229..242		2/12 (17%)
		ANK 7	238..268		11/67 (16%)
		Ank_2	243..326	CDD:289560	27/139 (19%)
		2-5A binding (P-loop) 2	253..275		8/52 (15%)
		ANK repeat	272..326	CDD:293786	16/72 (22%)
		ANK 8	272..301		9/28 (32%)
		ANK 9	303..329		9/44 (20%)
		PKc_like	375..587	CDD:304357	33/215 (15%)
		Pkinase	387..586	CDD:278497	32/202 (16%)
		RNase_RNase-L	590..708	CDD:199218	16/90 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
slk	XP_031762309.1	STKc_SLK	28..310	CDD:270811
		PKK	957..1093	CDD:403615	28/141 (20%)
		PKK	1123..1263	CDD:403615	41/263 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910