DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RNASEL and pkn3

DIOPT Version :9

Sequence 1:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_001120197.1	Gene:	pkn3 / 100145241	XenbaseID:	XB-GENE-6085008	Length:	934	Species:	Xenopus tropicalis

Alignment Length:	282	Identity:	61/282 - (21%)
Similarity:	103/282 - (36%)	Gaps:	75/282 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   377 GGIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQ---------SSRENSHLVTFYGSESHRGHL 430
            |.:.||.:::  :..|:|...:....::.|:..||         :|..:..||..:|....:||
Frog   616 GKVLLGQFKETGKNFAIKALKKRDIVSRDELESLQCEKRIFEAVNSSGHPFLVNLFGCFQTQGH- 679

Human   431 FVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDS 495
             .|..: |......|.:|...:|.:|..  ||...:.:...:|.||... ..::||:..|:|:|:
Frog   680 -ACFVM-EYMPGGDLMMHIHSNVFSEPT--ARFYSACVVLGLQFLHEKM-IIYRDLKLDNLLMDA 739

Human   496 KKAAHLADF----------DKSIKWAGDPQ----EVKRDLEDLGRLVLYVVK---KGSISFEDLK 543
            .....:|||          |::..:.|.|:    ||..|..     ..|.|.   .|.:.||.|.
Frog   740 SGFVKIADFGLCKEGMGFGDRTSTFCGTPEFLAPEVLTDTS-----YTYAVDWWGLGVLIFEMLV 799

Human   544 AQ------SNEEVVQLSPDEETK----------DLIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 592
            .:      ..|||.....:||.:          ::|.:|.......|      ||
Frog   800 GECPFPGDDEEEVFDSIVNEEVRYPRFLSNDAINIIRKLLRKSPERR------LG---------- 848

Human   593 YRTLRNVGNESDIKTRKSESEI 614
                ..||:..:||.:....||
Frog   849 ----AGVGDAEEIKPQLFFQEI 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786
		ANK 1	24..53
		Ank_2	29..122	CDD:289560
		ANK 2	58..87
		ANK	59..188	CDD:238125
		ANK repeat	59..89	CDD:293786
		ANK repeat	91..122	CDD:293786
		ANK 3	91..120
		Ank_2	96..199	CDD:289560
		ANK repeat	124..154	CDD:293786
		ANK 4	124..153
		ANK repeat	167..199	CDD:293786
		ANK 5	167..197
		Ank_2	172..270	CDD:289560
		ANK	196..321	CDD:238125
		ANK repeat	201..236	CDD:293786
		ANK 6	201..234
		2-5A binding (P-loop) 1	229..242
		ANK 7	238..268
		Ank_2	243..326	CDD:289560
		2-5A binding (P-loop) 2	253..275
		ANK repeat	272..326	CDD:293786
		ANK 8	272..301
		ANK 9	303..329
		PKc_like	375..587	CDD:304357	55/253 (22%)
		Pkinase	387..586	CDD:278497	52/240 (22%)
		RNase_RNase-L	590..708	CDD:199218	6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
pkn3	NP_001120197.1	HR1_PKN_1	17..82	CDD:212012
		HR1_PKN3_2	103..176	CDD:212022
		HR1_PKN3_3	186..259	CDD:212027
		C2	362..445	CDD:301316
		STKc_PKN	604..929	CDD:270741	61/282 (22%)
		S_TKc	604..849	CDD:214567	55/263 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910