DRSC/TRiP Functional Genomics Resources

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Protein Alignment RNASEL and kidins220

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:XP_012818173.1 Gene:kidins220 / 100145198 XenbaseID:XB-GENE-5839632 Length:1764 Species:Xenopus tropicalis


Alignment Length:376 Identity:117/376 - (31%)
Similarity:170/376 - (45%) Gaps:63/376 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGA 93
            ||.|.....:|:|..||..|||.|....:....|:..|......|||:|||::||......|.|.
 Frog   108 LIWASYKGSIDVVDLLLSKGANPNITGLQYSVYPVIWAAGRGHSDIVKLLLQYGAKVNCSDKFGT 172

Human    94 TPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158
            ||.|.||..|.::.:|..|..||||::......||.:.|...|....:|.:.||..||||   |.
 Frog   173 TPLIWAARKGHLECVKYLLQMGADVDQEGANSITALIVAVKGGYTDTVKEILKRNPNVNL---TD 234

Human   159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223
            :|       |.|||..||::||.|:::.||| .|..||..|..|...||.|:..   ..|| |..
 Frog   235 KD-------GNTALTIAAKEGHTEIVQDLLD-AGTYVNIPDRNGDTVLIGAVRG---GHVE-IVR 287

Human   224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD---SDGKTALLLAVELKL 285
            .||:..||:::||:..||.|..||||.:..:|:.:|:..    .||:   .||:|.|:.|.:::.
 Frog   288 ALLNKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCN----PDTEFSTKDGETPLIKATKMRS 348

Human   286 KKIAELLCKRGASTDC----GDLVM-TARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGA 345
            .::.|||..:||....    ||..: .|.|.....|.::||.:.                     
 Frog   349 IEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNP--------------------- 392

Human   346 ALKDLHRIYRP-MIGKLKFFIDEKYK------------IADTSEGGIYLGF 383
              ||...:||| ..|:..:.||..::            ::.|...|..||:
 Frog   393 --KDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTESDGDMLGY 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786 11/26 (42%)
ANK 1 24..53 10/23 (43%)
Ank_2 29..122 CDD:289560 35/92 (38%)
ANK 2 58..87 10/28 (36%)
ANK 59..188 CDD:238125 46/128 (36%)
ANK repeat 59..89 CDD:293786 10/29 (34%)
ANK repeat 91..122 CDD:293786 13/30 (43%)
ANK 3 91..120 13/28 (46%)
Ank_2 96..199 CDD:289560 38/102 (37%)
ANK repeat 124..154 CDD:293786 10/29 (34%)
ANK 4 124..153 9/28 (32%)
ANK repeat 167..199 CDD:293786 15/31 (48%)
ANK 5 167..197 14/29 (48%)
Ank_2 172..270 CDD:289560 36/97 (37%)
ANK 196..321 CDD:238125 41/132 (31%)
ANK repeat 201..236 CDD:293786 11/34 (32%)
ANK 6 201..234 11/32 (34%)
2-5A binding (P-loop) 1 229..242 5/12 (42%)
ANK 7 238..268 9/29 (31%)
Ank_2 243..326 CDD:289560 26/90 (29%)
2-5A binding (P-loop) 2 253..275 6/24 (25%)
ANK repeat 272..326 CDD:293786 17/58 (29%)
ANK 8 272..301 10/28 (36%)
ANK 9 303..329 6/26 (23%)
PKc_like 375..587 CDD:304357 3/9 (33%)
Pkinase 387..586 CDD:278497
RNase_RNase-L 590..708 CDD:199218
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
kidins220XP_012818173.1 Ank_4 9..58 CDD:290365
ANK 32..191 CDD:238125 30/82 (37%)
ANK repeat 37..68 CDD:293786
Ank_2 42..133 CDD:289560 11/24 (46%)
ANK repeat 70..101 CDD:293786
ANK repeat 104..134 CDD:293786 11/25 (44%)
ANK repeat 137..168 CDD:293786 10/30 (33%)
Ank_2 143..234 CDD:289560 34/93 (37%)
ANK 165..290 CDD:238125 50/139 (36%)
ANK repeat 170..198 CDD:293786 12/27 (44%)
Ank_2 208..299 CDD:289560 38/105 (36%)
ANK 231..356 CDD:238125 51/143 (36%)
ANK repeat 236..267 CDD:293786 16/38 (42%)
ANK repeat 269..299 CDD:293786 11/33 (33%)
ANK repeat 302..366 CDD:293786 21/67 (31%)
Ank_2 307..394 CDD:289560 26/113 (23%)
KAP_NTPase 441..955 CDD:284995 0/1 (0%)
SAM_superfamily 1215..1281 CDD:301707
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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