DRSC/TRiP Functional Genomics Resources

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Protein Alignment RNASEL and mapk13

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:XP_031751532.1 Gene:mapk13 / 100144715 XenbaseID:XB-GENE-490713 Length:377 Species:Xenopus tropicalis


Alignment Length:352 Identity:73/352 - (20%)
Similarity:119/352 - (33%) Gaps:122/352 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIF--KAVQELHLSCGYTH 483
            |||        ||         :.:|:..||.|..:  :.:|...|.||  :|.:||.|.....|
 Frog    36 YGS--------VC---------SAIDLKTGEKVAIK--KLSRPFQSEIFAKRAFRELTLLKHMNH 81

Human   484 QD---------------------LQPQNILIDSKK--AAHLADFDKSIKWAGDPQEVKRDLEDLG 525
            ::                     |....:.||.:|  ..||:: ||                   
 Frog    82 ENVIGLLDVFTSATSFNDFHNFYLVMPYMQIDLQKIMGHHLSE-DK------------------- 126

Human   526 RLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHV--RDCLSDLLGHPFFWT 588
              |.|:|.:.....:.:.|..               :|||...||...  .||...:|....   
 Frog   127 --VQYLVYQMLCGLKYIHAAG---------------IIHRDLKPGNLAVNEDCELKILDFGL--- 171

Human   589 WESRYRTLRNVGNESDIKTR--KSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKM----NKF 647
              :|:......|.   :.||  ::...||..:     .::|:.|.|:.   .|:|.:|    ..|
 Frog   172 --ARHADAEMTGY---VVTRWYRAPEVILNWM-----HYNKTVDIWSV---GCIMGEMLTGKTLF 223

Human   648 YEKRGNFYQNTVGDLLK--------FIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFP---DLVI 701
               :|..|.:.:..:||        ||:.| |.:..:|:.:...||  |...|...||   ||.:
 Frog   224 ---KGKDYLDQLTQILKVTGVPGPEFIQKL-EDMAAKKYIQSLPKI--PKKEFSLLFPNASDLAV 282

Human   702 YVYTKLQNTEYRKHFPQTHSPNKPQCD 728
            .:..|:...:..|....|.:...|..|
 Frog   283 DLLEKMLELDVEKRLTATEALEHPYFD 309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786
ANK 1 24..53
Ank_2 29..122 CDD:289560
ANK 2 58..87
ANK 59..188 CDD:238125
ANK repeat 59..89 CDD:293786
ANK repeat 91..122 CDD:293786
ANK 3 91..120
Ank_2 96..199 CDD:289560
ANK repeat 124..154 CDD:293786
ANK 4 124..153
ANK repeat 167..199 CDD:293786
ANK 5 167..197
Ank_2 172..270 CDD:289560
ANK 196..321 CDD:238125
ANK repeat 201..236 CDD:293786
ANK 6 201..234
2-5A binding (P-loop) 1 229..242
ANK 7 238..268
Ank_2 243..326 CDD:289560
2-5A binding (P-loop) 2 253..275
ANK repeat 272..326 CDD:293786
ANK 8 272..301
ANK 9 303..329
PKc_like 375..587 CDD:304357 38/192 (20%)
Pkinase 387..586 CDD:278497 38/191 (20%)
RNase_RNase-L 590..708 CDD:199218 31/134 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741 3/14 (21%)
mapk13XP_031751532.1 STKc_p38delta 9..352 CDD:143384 73/352 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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