DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RNASEL and septin5

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:XP_012821807.1 Gene:septin5 / 100125069 XenbaseID:XB-GENE-5829803 Length:404 Species:Xenopus tropicalis


Alignment Length:312 Identity:63/312 - (20%)
Similarity:108/312 - (34%) Gaps:104/312 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    32 AVQNED-----VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLR----------H 81
            ||.|.:     .|.:.|..|    ..|::|.|          ::|::|.:..:.          |
 Frog   140 AVNNNECWKPITDYIDQQFE----QYFRDESG----------LNRKNIQDNRVHCCLYFISPFGH 190

Human    82 GADPV-------LRKKNGATPFILAA---IAGSVKLLK--------LFLSKGADVNECDFYGFTA 128
            |..||       |.:|....|.|..|   |.|.::.||        .|..|.....|||......
 Frog   191 GLRPVDVAFMKALHEKVNIVPLIAKADCLIPGEIRKLKDRIREEIEKFGIKVYQFPECDSDEDDD 255

Human   129 F-------MEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186
            |       .|:|.:..:         |:|..:..|.:..:.||...|   :::...:.|.:.:|:
 Frog   256 FKQQDRELKESAPFAVI---------GSNTVVEAKGQRVRGRLYPWG---IVEVENQAHCDFVKL 308

Human   187 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHL--LLDHGADVNVRGERGK-TPLILAVE 248
                            ||.||.             ||:  |.|...||:....|.: ...:...|
 Frog   309 ----------------RNMLIR-------------THMHDLKDVTCDVHYENYRAQCIQQMTRNE 344

Human   249 KKHLGLVQRLLEQEHIE-----INDTDSDGKTALLLAV-ELKLKKIAELLCK 294
            ::|.....:|.:...||     :.....|.:|..|:.: :.:|:::.|:|.|
 Frog   345 ERHNTASSKLTQDNRIESPIPILPLPTPDAETEKLIKMKDEELRRMQEMLQK 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786 7/28 (25%)
ANK 1 24..53 6/25 (24%)
Ank_2 29..122 CDD:289560 27/122 (22%)
ANK 2 58..87 7/45 (16%)
ANK 59..188 CDD:238125 31/163 (19%)
ANK repeat 59..89 CDD:293786 7/46 (15%)
ANK repeat 91..122 CDD:293786 10/41 (24%)
ANK 3 91..120 9/39 (23%)
Ank_2 96..199 CDD:289560 22/120 (18%)
ANK repeat 124..154 CDD:293786 5/36 (14%)
ANK 4 124..153 5/35 (14%)
ANK repeat 167..199 CDD:293786 3/31 (10%)
ANK 5 167..197 3/29 (10%)
Ank_2 172..270 CDD:289560 18/105 (17%)
ANK 196..321 CDD:238125 23/108 (21%)
ANK repeat 201..236 CDD:293786 10/36 (28%)
ANK 6 201..234 10/34 (29%)
2-5A binding (P-loop) 1 229..242 3/13 (23%)
ANK 7 238..268 6/35 (17%)
Ank_2 243..326 CDD:289560 12/58 (21%)
2-5A binding (P-loop) 2 253..275 4/26 (15%)
ANK repeat 272..326 CDD:293786 7/24 (29%)
ANK 8 272..301 7/24 (29%)
ANK 9 303..329
PKc_like 375..587 CDD:304357
Pkinase 387..586 CDD:278497
RNase_RNase-L 590..708 CDD:199218
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741
septin5XP_012821807.1 Septin 66..346 CDD:366275 52/260 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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