DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RNASEL and cdk16

DIOPT Version :9

Sequence 1:NP_066956.1 Gene:RNASEL / 6041 HGNCID:10050 Length:741 Species:Homo sapiens
Sequence 2:XP_031762670.1 Gene:cdk16 / 100037876 XenbaseID:XB-GENE-5856779 Length:522 Species:Xenopus tropicalis


Alignment Length:446 Identity:100/446 - (22%)
Similarity:155/446 - (34%) Gaps:187/446 - (41%)


- Green bases have known domain annotations that are detailed below.


Human   316 LVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMI--GKLKFFIDEKYKIADTSEGG 378
            |.|:.||       .||.:  ||.|       :.|.|:....|  |||:.:| :..|:.:.:...
 Frog   158 LEKLALS-------SPPFD--KPLS-------RRLRRVSLSEIGFGKLETYI-KLDKLGEGTYAT 205

Human   379 IYLGFYEKQE--VAVKTFC----EGSP-RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTL 436
            :|.|..:..|  ||:|...    ||:| .|.||||.|:..: ::::||.:.           :..
 Frog   206 VYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLK-HANIVTLHD-----------IIH 258

Human   437 CEQTLEACLDVHRGEDVENEEDEFARNV-LSSIFKAVQELHLSCGY------THQDLQPQNILID 494
            .|:||....: :..:|::...|:....: |.::...:.:|.....|      .|:||:|||:||:
 Frog   259 TERTLTLVFE-YLDKDLKQYLDDCGNLINLHNVKLFLYQLLRGLSYCHRRKVLHRDLKPQNLLIN 322

Human   495 SKKAAHLADFD----KSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSP 555
            .|....||||.    |||                                ..|..|||.|.    
 Frog   323 EKGELKLADFGLARAKSI--------------------------------PTKTYSNEVVT---- 351

Human   556 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQP 620
                                          .|     ||       ..||           ||  
 Frog   352 ------------------------------LW-----YR-------PPDI-----------LL-- 361

Human   621 GPSEHSKSFDKWTTKINECVMKKMNKFYEK---RGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMK 682
            |.:|:|...|.|..   .|:      |||.   |..|..:||.:.|.||..:             
 Frog   362 GSTEYSTQIDMWGV---GCI------FYEMVTGRPLFPGSTVEEQLHFIFRI------------- 404

Human   683 LKIGDPSLYFQKTFPDLVIYVYTKLQNTE-----YRKHFP---QTHSPNKPQCDGA 730
              :|.|:   ::|:|.:       |.|.|     |.:::|   |.|:. :...|||
 Frog   405 --LGTPT---EETWPGI-------LSNEEFKSYNYPRYYPDPIQKHAA-RLDSDGA 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RNASELNP_066956.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..56 CDD:293786
ANK 1 24..53
Ank_2 29..122 CDD:289560
ANK 2 58..87
ANK 59..188 CDD:238125
ANK repeat 59..89 CDD:293786
ANK repeat 91..122 CDD:293786
ANK 3 91..120
Ank_2 96..199 CDD:289560
ANK repeat 124..154 CDD:293786
ANK 4 124..153
ANK repeat 167..199 CDD:293786
ANK 5 167..197
Ank_2 172..270 CDD:289560
ANK 196..321 CDD:238125 2/4 (50%)
ANK repeat 201..236 CDD:293786
ANK 6 201..234
2-5A binding (P-loop) 1 229..242
ANK 7 238..268
Ank_2 243..326 CDD:289560 4/9 (44%)
2-5A binding (P-loop) 2 253..275
ANK repeat 272..326 CDD:293786 4/9 (44%)
ANK 8 272..301
ANK 9 303..329 4/12 (33%)
PKc_like 375..587 CDD:304357 46/229 (20%)
Pkinase 387..586 CDD:278497 44/216 (20%)
RNase_RNase-L 590..708 CDD:199218 26/120 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 715..741 6/19 (32%)
cdk16XP_031762670.1 PKc_like 189..485 CDD:419665 86/399 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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