DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BCL6 and CG10321

DIOPT Version :9

Sequence 1:NP_001124317.1 Gene:BCL6 / 604 HGNCID:1001 Length:706 Species:Homo sapiens
Sequence 2:NP_001261124.1 Gene:CG10321 / 37464 FlyBaseID:FBgn0034643 Length:855 Species:Drosophila melanogaster


Alignment Length:289 Identity:68/289 - (23%)
Similarity:102/289 - (35%) Gaps:52/289 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   425 LQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMC 489
            |..|| ::.|....|..:|.|.|:.:...:|..|                   |..|.|      
  Fly   530 LVGPT-MTVSSASPTPKRAKRSNHQIPAGVTLEP-------------------CDHQPP------ 568

Human   490 LHTAGPTFPEEMGETQS----EYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDR 550
              .||.|...::....|    :.:......||....|.|.....| .:::||....|.: |.|..
  Fly   569 --AAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTE-FIRQHTSPLGSGR-YICHL 629

Human   551 CQASFRYKGNLASHKTVHTG------EKPYRCNICGAQFNRPANLKTHTRIHSGEKPY-KCETCG 608
            |...||....|.:|...||.      :|..:|.||...|..|..|:.|.:.|..|... .|..|.
  Fly   630 CSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPMCTICN 694

Human   609 ARFVQVAHLRAHVLIHTGEKPYPCEI--CGTRFRHLQTLKSHL-RIH--TGEKPYHCEKCNLHFR 668
            ..|...|.|..|...|. ::.|.|.:  |...|.....||.|: |.|  ..:..:.|.:|...:.
  Fly   695 RTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKHPEVVDPLFKCGECGSLYD 758

Human   669 HKSQLRLHLRQKHGAITNTKVQYRVSATD 697
            :...|:||:..     |:...:.::|..|
  Fly   759 NVDSLQLHVES-----TDHSAEVQISGQD 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BCL6NP_001124317.1 BTB 22..126 CDD:279045
BTB 33..126 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..349
Required for interaction with NuRD complex and for transcriptional repressor activity 376..379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..467 10/41 (24%)
C2H2 Zn finger 520..541 CDD:275368 5/20 (25%)
C2H2 Zn finger 548..568 CDD:275368 6/19 (32%)
zf-H2C2_2 560..585 CDD:290200 9/30 (30%)
C2H2 Zn finger 576..596 CDD:275368 7/19 (37%)
zf-H2C2_2 588..613 CDD:290200 7/25 (28%)
C2H2 Zn finger 604..624 CDD:275368 6/19 (32%)
zf-H2C2_2 616..641 CDD:290200 7/26 (27%)
C2H2 Zn finger 632..652 CDD:275368 7/22 (32%)
zf-H2C2_2 645..669 CDD:290200 7/26 (27%)
C2H2 Zn finger 660..678 CDD:275368 5/17 (29%)
CG10321NP_001261124.1 zf-AD 12..80 CDD:214871
ASF1_hist_chap <405..516 CDD:304562
C2H2 Zn finger 627..647 CDD:275368 6/19 (32%)
C2H2 Zn finger 661..681 CDD:275368 7/19 (37%)
C2H2 Zn finger 690..710 CDD:275368 6/19 (32%)
C2H2 Zn finger 717..740 CDD:275368 7/22 (32%)
C2H2 Zn finger 750..767 CDD:275368 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24399
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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