DRSC/TRiP Functional Genomics Resources

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Protein Alignment BCL6 and Clamp

DIOPT Version :10

Sequence 1:NP_001697.2 Gene:BCL6 / 604 HGNCID:1001 Length:706 Species:Homo sapiens
Sequence 2:NP_001014498.1 Gene:Clamp / 35445 FlyBaseID:FBgn0032979 Length:566 Species:Drosophila melanogaster


Alignment Length:470 Identity:134/470 - (28%)
Similarity:190/470 - (40%) Gaps:122/470 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   282 KPAAPSARNAPYFPCDKAS---------------------KEEERPSSE---DEIALHFEPPNAP 322
            ||.|.:..:...|.||..|                     :::::.:::   |.||:        
  Fly   115 KPIAANTISNISFKCDVCSDMFPHLALLNAHKRMHTDGEQQQQQQHNAQAGGDSIAV-------- 171

Human   323 LNRKGLVSPQS-------------------PQKSDCQPNSPTESCSSKNACILQASGSPPAKSPT 368
            ::.:|||..|:                   |.:.........||.:||  ||             
  Fly   172 VSAQGLVQAQNIIGNGQMGQIQIVSSDTLEPVQQSVMQQQQHESKASK--CI------------- 221

Human   369 DPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSA 433
               .|.         :|:.|.:|.:||:|..              |:..|:.|....|......|
  Fly   222 ---NCG---------SSMLQQSKRKGPKQVR--------------CESCMQAEQTAQQQQQLFVA 260

Human   434 SGED--------STIPQA-SRLNNIVNRSMTGSPRSSSESHSPLYMHP---------PKCTSCGS 480
            ....        ||.||| ::|..|| .:.||......|:.|....||         .||..|..
  Fly   261 QDGQMAHPVQIISTTPQAQAQLQQIV-AAQTGGTTPKREASSGSGHHPVKKRNSQQMTKCQKCNG 324

Human   481 QS----PQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGA--FFCNECDCRFSEEASLKRHTLQ 539
            ..    .||:.......|.:..:.: ..::|.  .||.|.:  |.||.|...||..:||..|...
  Fly   325 SGVVLVGQHSHASHSGVGGSVKQSV-TVKTEC--LSCRNPSKPFSCNICGGLFSRYSSLWSHKKL 386

Human   540 THSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKC 604
            ...:|.|||..|..:|.....|.:|..:|||||||:|..||.||::..:||.|.|.||||:||.|
  Fly   387 HSGEKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERTHSGERPYVC 451

Human   605 ETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRH 669
            ..|...|.:.|.|..|..||||||||.|||||:.|.....||:|.::|:|||||.||.|:..|..
  Fly   452 GVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKCEICSAAFAD 516

Human   670 KSQLRLH--LRQKHG 682
            :..|:.|  :.||:|
  Fly   517 RFALKRHRGIHQKYG 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BCL6NP_001697.2 BTB_POZ_ZBTB27_BCL6 8..125 CDD:349640
PHA03247 <172..426 CDD:223021 31/186 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..349 7/50 (14%)
Required for interaction with NuRD complex and for transcriptional repressor activity 376..379 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..467 16/68 (24%)
C2H2 Zn finger 520..541 CDD:275368 8/20 (40%)
C2H2 Zn finger 548..568 CDD:275368 5/19 (26%)
zf-H2C2_2 560..585 CDD:463886 14/24 (58%)
C2H2 Zn finger 576..596 CDD:275368 9/19 (47%)
zf-H2C2_2 588..613 CDD:463886 13/24 (54%)
C2H2 Zn finger 604..624 CDD:275368 6/19 (32%)
zf-H2C2_2 616..641 CDD:463886 16/24 (67%)
C2H2 Zn finger 632..652 CDD:275368 9/19 (47%)
zf-H2C2_2 645..669 CDD:463886 13/23 (57%)
C2H2 Zn finger 660..678 CDD:275368 6/19 (32%)
ClampNP_001014498.1 COG5048 <359..498 CDD:227381 63/138 (46%)
C2H2 Zn finger 367..387 CDD:275368 8/19 (42%)
C2H2 Zn finger 395..415 CDD:275368 5/19 (26%)
zf-H2C2_2 407..432 CDD:463886 14/24 (58%)
C2H2 Zn finger 423..443 CDD:275368 9/19 (47%)
C2H2 Zn finger 451..471 CDD:275368 6/19 (32%)
COG5048 475..>529 CDD:227381 24/53 (45%)
C2H2 Zn finger 479..499 CDD:275368 9/19 (47%)
C2H2 Zn finger 507..527 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

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