DRSC/TRiP Functional Genomics Resources

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Protein Alignment RING1 and Sce

DIOPT Version :9

Sequence 1:NP_002922.2 Gene:RING1 / 6015 HGNCID:10018 Length:406 Species:Homo sapiens
Sequence 2:NP_477509.1 Gene:Sce / 43327 FlyBaseID:FBgn0003330 Length:435 Species:Drosophila melanogaster


Alignment Length:492 Identity:203/492 - (41%)
Similarity:238/492 - (48%) Gaps:153/492 - (31%)


- Green bases have known domain annotations that are detailed below.


Human     1 MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECL 65
            ||:...|.|  ||||||||||.|.|||.|.|.||||||||||||||||||||||||.||||||||
  Fly     1 MTSLDPAPN--KTWELSLYELQRKPQEVITDSTEIAVSPRSLHSELMCPICLDMLKKTMTTKECL 63

Human    66 HRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSR 130
            |||||||||||||||||||||||||||||||||.|||||.||||||||||||||.|::|:.:.::
  Fly    64 HRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYPSREEYEAIQEKVMAKFNQ 128

Human   131 LHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGEGDGEDVSSDSAPDSA 195
            ..:||||.:||.||:::|:.:|.||.|          |..||.|..|.|.|:|       |.:.|
  Fly   129 TQSQQALVNSINEGIKLQSQNRPQRFR----------TKGGGGGGGGGGNGNG-------AANVA 176

Human   196 PGPAPKRPRGGGAGGSSV-----------------------GTGGGGTGGV-----GGGAGSEDS 232
            ..|||..|...|...|:.                       ..|..||...     ...|....|
  Fly   177 APPAPGAPTAVGRNASNQMHVHDTASNDSNSNTNSIDRENRDPGHSGTSAASAITSASNAAPSSS 241

Human   233 GDRGGTLGGGTL------GPPSPPGAPSP------------------------------------ 255
            .:.|.:.....:      .|||....|||                                    
  Fly   242 ANSGASTSATRMQVDDASNPPSVRSTPSPVPSNSSSSKPKRAMSVLTSERSEESESDSQMDCRTE 306

Human   256 --------PEPGG------EIELVFRPHP--------LLVEKGEYCQTRYVKTTGNATVDHLSKY 298
                    .|..|      ||||||:|||        |:....|.| .||:|||.||||||||||
  Fly   307 GDSNIDTEGEGNGELGINDEIELVFKPHPTEMSADNQLIRALKENC-VRYIKTTANATVDHLSKY 370

Human   299 LALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQYTI 363
            ||:|:.|:.                                 |.|.|        |......:.|
  Fly   371 LAMRLTLDL---------------------------------GADLP--------EACRVLNFCI 394

Human   364 YIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYA 400
            |:||.......|||:.||..||:|||||::|:|:.|:
  Fly   395 YVAPQPQQLVILNGNQTLHQVNDKFWKVNKPMEMYYS 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RING1NP_002922.2 Necessary for transcriptional repression. /evidence=ECO:0000250 30..234 121/231 (52%)
RING-HC_RING1 47..90 CDD:319653 41/42 (98%)
RING-HC finger (C3HC4-type) 48..87 CDD:319653 37/38 (97%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 148..263 36/198 (18%)
Nuclear localization signal. /evidence=ECO:0000255 201..204 0/2 (0%)
Necessary for interaction with CBX2. /evidence=ECO:0000250 230..406 64/235 (27%)
RAWUL 282..400 CDD:318447 41/117 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 309..354 3/44 (7%)
SceNP_477509.1 RING 45..89 CDD:238093 42/43 (98%)
RAWUL 336..431 CDD:292824 44/136 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 93 1.000 Domainoid score I7553
eggNOG 1 0.900 - - E1_KOG0311
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 332 1.000 Inparanoid score I2431
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48576
OrthoDB 1 1.010 - - D1319463at2759
OrthoFinder 1 1.000 - - FOG0003138
OrthoInspector 1 1.000 - - otm41319
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR46076
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3349
SonicParanoid 1 1.000 - - X2531
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.970

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