Protein Alignment RING1 and Psc

DIOPT Version :10

• Sequence 1: NP_002922.2
• Gene: RING1 / 6015
• HGNCID: 10018
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_523725.2
• Gene: Psc / 36431
• FlyBaseID: FBgn0005624
• Length: 1601
• Species: Drosophila melanogaster
• Alignment Length: 195
• Identity: 47/195 - (24%)
• Similarity: 76/195 - (38%)
• Gaps: 36/195 - (18%)

Human     3 TPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHR 67
            |.|.|.:::.|....|....| |:..::    .||:|     .::|.:|...|.|..|..||||.
  Fly   228 TAAVAASSTATTTSDLATTSR-PRPVLL----TAVNP-----HIICHLCQGYLINATTIVECLHS 282

Human    68 FCSDCIVTALRSGNKECPTCRKKL-VSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRL 131
            ||..|::..||. .:.||.|...: .:|.:::.|....|::.|:.|...|.|..:.|...:
  Fly   283 FCHSCLINHLRK-ERFCPRCEMVINNAKPNIKSDTTLQAIVYKLVPGLYERELMRKRAFYK---- 342

Human   132 HNQQALSSSIEEGLRMQAMHRAQRVRRPI--PGSDQTTTMSGGE-GEPGEGEGDGEDVSSDSAPD 193
                   ...||........|.......|  |..|.:.::...| ||          :.:||.|:
  Fly   343 -------DRPEEAALATPEQRGDDTEHLIFSPSDDMSLSLEYAELGE----------LKTDSEPE 390

Human   194  193
              Fly   391  390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RING1	NP_002922.2	Necessary for transcriptional repression. /evidence=ECO:0000250	30..234		40/168 (24%)
		RING-HC_RING2	34..110	CDD:438398	23/76 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..263		10/49 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	201..204
		Necessary for interaction with CBX2. /evidence=ECO:0000250	230..406
		RAWUL_RING1	261..400	CDD:340686
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..354
Psc	NP_523725.2	RING_Ubox	254..341	CDD:473075	28/96 (29%)
		RAWUL_PCGF2_like	371..465	CDD:340602	6/30 (20%)
		PHA03247	<1160..1381	CDD:223021