Protein Alignment RHO and ninaE

DIOPT Version :10

• Sequence 1: NP_000530.1
• Gene: RHO / 6010
• HGNCID: 10012
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_524407.1
• Gene: ninaE / 42367
• FlyBaseID: FBgn0002940
• Length: 373
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 107/374 - (28%)
• Similarity: 191/374 - (51%)
• Gaps: 51/374 - (13%)

Human     6 GPNFYVPFSNATGVVR---------SPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYV 61
            ||:| .|.||.:.|.:         ||: :.|:...:|....:|.|||.::.::.:..|.:.:|:
  Fly    12 GPHF-APLSNGSVVDKVTPDMAHLISPY-WNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYI 74

Human    62 TVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYF---VFGPTGCNLEGFFATLG--- 120
            ....|.||||.|.:::|||::|..:::   |:|....::.||   |.||..|::   :|.||
  Fly    75 FATTKSLRTPANLLVINLAISDFGIMI---TNTPMMGINLYFETWVLGPMMCDI---YAGLGSAF 133

Human   121 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQC 185
            |..::||:.:::::||.|:.|.|:........|:..:|:.|.|:......|..|||||:|||...
  Fly   134 GCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNLT 198

Human   186 SCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVK--EAAAQQQESATTQK--- 245
            ||||||  |:.:.|..|::|:..:..:.||:.:|.:.|..::..|.  |.|.::|......|
  Fly   199 SCGIDY--LERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSLR 261

Human   246 --------AEKEVTRMVIIMVIAFLICWVPYASV-AFYIFTHQGSNFGPIFMTIPAFFAKSAAIY 301
                    ||.::.::.::.:..:.:.|.||..: ...:|..:|  ..|:.....|.||||||.|
  Fly   262 SSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEG--LTPLNTIWGACFAKSAACY 324

Human   302 NPVIYIMMNKQFRNCMLTTI-CC-------GKNPLGDDEASATVSKTET 342
            ||::|.:.:.::|..:.... ||       ||:  .|.::.||.|:.|:
  Fly   325 NPIVYGISHPKYRLALKEKCPCCVFGKVDDGKS--SDAQSQATASEAES 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHO	NP_000530.1	Rhodopsin_N	3..37	CDD:313611	11/39 (28%)
		7tmA_MWS_opsin	38..317	CDD:381742	87/298 (29%)
		TM helix 1	39..65	CDD:381742	6/25 (24%)
		TM helix 2	72..99	CDD:381742	7/26 (27%)
		TM helix 3	110..140	CDD:381742	10/32 (31%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305|PubMed:26200343	134..136		0/1 (0%)
		TM helix 4	151..173	CDD:381742	5/21 (24%)
		TM helix 5	200..230	CDD:381742	6/29 (21%)
		TM helix 6	245..275	CDD:381742	6/41 (15%)
		TM helix 7	285..310	CDD:381742	12/24 (50%)
		Interaction with SAG. /evidence=ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425	330..348		5/13 (38%)
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	87/297 (29%)
		TM helix 1	52..78	CDD:320207	6/25 (24%)
		TM helix 2	85..111	CDD:320207	7/28 (25%)
		TM helix 3	123..153	CDD:320207	10/32 (31%)
		TM helix 4	164..184	CDD:320207	4/19 (21%)
		TM helix 5	211..240	CDD:320207	6/28 (21%)
		TM helix 6	269..299	CDD:320207	5/29 (17%)
		TM helix 7	308..333	CDD:320207	12/24 (50%)