Protein Alignment RHO and sprr-1

DIOPT Version :9

• Sequence 1: NP_000530.1
• Gene: RHO / 6010
• HGNCID: 10012
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_510555.2
• Gene: sprr-1 / 3564903
• WormBaseID: WBGene00010986
• Length: 527
• Species: Caenorhabditis elegans
• Alignment Length: 403
• Identity: 86/403 - (21%)
• Similarity: 149/403 - (36%)
• Gaps: 127/403 - (31%)

Human    35 WQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADL------------FMV 87
            |...|....|..::.|....|.. :.|.:.||.||||.||:||.:||.:|            :..
 Worm    27 WAVPMYGYMMPFIVTLTVATNSF-IVVVLSHKYLRTPTNYVLLAMAVTELLTGLSCLPWFTYYYT 90

Human    88 LGGFTSTLYTSLHGYFVFGPTGCN----LEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRF 148
            |.|:.:.|.|.|..::      |:    :..|..::...:|:|..|.|||:||:.:|.|....:|
 Worm    91 LSGYKNDLQTGLPSFW------CDMIPYMAAFLPSIFHTMAIWLTVYLAIQRYIYICVPSLVRKF 149

Human   149 GENHAIMGVAFTWVMALACA--APPLAG--------------------WSRYIPEGLQCSCGIDY 191
            ...|....|.| :::::|..  .|.|..                    :....|..|:....|.|
 Worm   150 CTIHRSKQVIF-FIISVATIMYTPDLMAFHNKSHDVFDSKRNRTMKLCYRHRAPFMLKLGDDIYY 213

Human   192 YTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEA----------------AAQQQES 240
            ..:        |......||. ||.:::.....:||..::.|                :.:::.|
 Worm   214 KVM--------FTTQTVAVHL-IPSVLLVIFTWKLVGAIRVADRRHANLLSKYSTTTRSTRRKFS 269

Human   241 ATTQKAE---------------------------KEVTRMVIIMVIAFLICWVPYA--------- 269
            ..|..:|                           |:.|||::::::.|||..:|.|
 Worm   270 ELTNSSENENKITRLFKQRDSVSVGNEPRRAHGLKQNTRMLVVVILLFLITEIPAALIFTIHVLS 334

Human   270 -SVAFYIFTHQGSNF------GPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGK-- 325
             |:.|....:|..|.      ..|.::.|..||         ||..|::|||: ::..:..||
 Worm   335 VSLKFSFVDYQFLNILLIVRNVLIVVSYPFRFA---------IYCGMSQQFRD-VVRQMFTGKML 389

Human   326 -NPLGDDEASATV 337
             :.:.|.:.|.|:
 Worm   390 THAIRDKDNSTTM 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHO	NP_000530.1	Rhodopsin_N	3..37	CDD:313611	1/1 (100%)
		7tmA_MWS_opsin	38..317	CDD:381742	80/375 (21%)
		TM helix 1	40..64	CDD:381742	4/23 (17%)
		TM helix 2	73..95	CDD:381742	9/33 (27%)
		TM helix 3	111..133	CDD:381742	5/25 (20%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305|PubMed:26200343	134..136		0/1 (0%)
		TM helix 4	155..171	CDD:381742	3/17 (18%)
		TM helix 5	201..224	CDD:381742	5/22 (23%)
		TM helix 6	251..273	CDD:381742	9/31 (29%)
		TM helix 7	285..310	CDD:381742	6/24 (25%)
		Interaction with SAG. /evidence=ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425	330..348		3/8 (38%)
sprr-1	NP_510555.2	7tmA_FMRFamide_R-like	30..380	CDD:320109	80/376 (21%)
		TM helix 1	32..56	CDD:320109	4/24 (17%)
		TM helix 2	64..86	CDD:320109	7/21 (33%)
		TM helix 3	112..134	CDD:320109	5/21 (24%)
		TM helix 4	157..175	CDD:320109	4/18 (22%)
		TM helix 5	214..237	CDD:320109	5/31 (16%)
		TM helix 6	279..329	CDD:320109	9/49 (18%)
		TM helix 7	348..373	CDD:320109	7/33 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910