Protein Alignment RHO and Rho

DIOPT Version :10

• Sequence 1: NP_000530.1
• Gene: RHO / 6010
• HGNCID: 10012
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_663358.1
• Gene: Rho / 212541
• MGIID: 97914
• Length: 348
• Species: Mus musculus
• Alignment Length: 348
• Identity: 330/348 - (94%)
• Similarity: 341/348 - (97%)
• Gaps: 0/348 - (0%)

Human     1 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQH 65
            |||||||||||||||.|||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse     1 MNGTEGPNFYVPFSNVTGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQH 65

Human    66 KKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVV 130
            ||||||||||||||||||||||.||||:|||||||||||||||||||||||||||||||||||||
Mouse    66 KKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVV 130

Human   131 LAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLK 195
            |||||||||||||||||||||||||||.|||:||||||||||.|||||||||:||||||||||||
Mouse   131 LAIERYVVVCKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLK 195

Human   196 PEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIA 260
            ||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||.
Mouse   196 PEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIF 260

Human   261 FLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGK 325
            |||||:|||||||||||||||||||||||:|||||||::|||||||||:|||||||||||:||||
Mouse   261 FLICWLPYASVAFYIFTHQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMLNKQFRNCMLTTLCCGK 325

Human   326 NPLGDDEASATVSKTETSQVAPA 348
            ||||||:||||.|||||||||||
Mouse   326 NPLGDDDASATASKTETSQVAPA 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHO	NP_000530.1	Rhodopsin_N	3..37	CDD:313611	31/33 (94%)
		7tmA_MWS_opsin	38..317	CDD:381742	265/278 (95%)
		TM helix 1	39..65	CDD:381742	25/25 (100%)
		TM helix 2	72..99	CDD:381742	24/26 (92%)
		TM helix 3	110..140	CDD:381742	29/29 (100%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305|PubMed:26200343	134..136		1/1 (100%)
		TM helix 4	151..173	CDD:381742	19/21 (90%)
		TM helix 5	200..230	CDD:381742	28/29 (97%)
		TM helix 6	245..275	CDD:381742	27/29 (93%)
		TM helix 7	285..310	CDD:381742	21/24 (88%)
		Interaction with SAG. /evidence=ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425	330..348		15/17 (88%)
Rho	NP_663358.1	Rhodopsin_N	3..37	CDD:313611	31/33 (94%)
		7tmA_MWS_opsin	38..317	CDD:381742	265/278 (95%)
		TM helix 1	39..65	CDD:381742	25/25 (100%)
		TM helix 2	72..99	CDD:381742	24/26 (92%)
		TM helix 3	110..140	CDD:381742	29/29 (100%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000250|UniProtKB:P02699	134..136		1/1 (100%)
		TM helix 4	151..173	CDD:381742	19/21 (90%)
		TM helix 5	200..230	CDD:381742	28/29 (97%)
		TM helix 6	245..275	CDD:381742	27/29 (93%)
		TM helix 7	285..310	CDD:381742	21/24 (88%)
		Interaction with SAG. /evidence=ECO:0000250|UniProtKB:P02699	330..348		15/17 (88%)