DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RHO and npr-6

DIOPT Version :9

Sequence 1:	NP_000530.1	Gene:	RHO / 6010	HGNCID:	10012	Length:	348	Species:	Homo sapiens
Sequence 2:	NP_509725.2	Gene:	npr-6 / 185623	WormBaseID:	WBGene00009619	Length:	402	Species:	Caenorhabditis elegans

Alignment Length:	343	Identity:	86/343 - (25%)
Similarity:	158/343 - (46%)	Gaps:	50/343 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    13 FSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILL 77
            :.:...:..:|.|. :|:  .|:..||..| :||:...|   |||.:||.:.:|:::|..|..:.
Worm    20 YQSTCKIKNNPMEM-EYF--RPFFISMYCA-VFLVASSG---NFLVVYVVMTNKRMQTITNIFIT 77

Human    78 NLAVADLFMVLGGFTS----TLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVV 138
            ||||:|:.:   .|||    ..|||: |:::||...|:....|......|:.|:|..:||:||:|
Worm    78 NLAVSDIMV---NFTSLWLTPTYTSI-GHWIFGGGLCHGLPLFQGTSIFISTWTLTAIAIDRYIV 138

Human   139 VCKPMSNFRFGENHAIMG----VAFTWVMALACAAPPLAGWS-RYIPEGLQCSCGIDYYTLKPEV 198
            :....||....:..::..    :...|:.:|....|...... .||.|    .|  |:.....:.
Worm   139 IVHNSSNININDRMSMRSCLSFIVLIWLCSLLLVTPYAINMKLNYIHE----PC--DFLICSEDW 197

Human   199 NNES----FVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAE----KEVTRMVI 255
            :|..    |.|.:.::.|.:|.::|...|.::...:     ..::|.|.:|::    |.:.||:|
Worm   198 SNAEFRSIFGIVVMILQFILPFVLIAISYIKIWLFL-----NSRQSMTERKSDIKRKKRLLRMLI 257

Human   256 IMVIAFLICWVPYASV----AFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNC 316
            :||:.|.|||.|:..:    ...:.......|..:|::: ...:.:|..:||::|..||:.||..
Worm   258 VMVVIFAICWFPFNLLNCLRDLKLDNFMRGYFSFVFLSV-HLMSMTATAWNPILYAFMNETFREE 321

Human   317 MLTTICC------GKNPL 328
            ....:.|      |..|:
Worm   322 FAKVVPCLFARRPGTGPI 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RHO	NP_000530.1	Rhodopsin_N	3..37	CDD:313611	4/23 (17%)
		7tmA_MWS_opsin	38..317	CDD:381742	79/299 (26%)
		TM helix 1	40..64	CDD:381742	9/23 (39%)
		TM helix 2	73..95	CDD:381742	9/25 (36%)
		TM helix 3	111..133	CDD:381742	4/21 (19%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305\|PubMed:26200343	134..136		0/1 (0%)
		TM helix 4	155..171	CDD:381742	2/19 (11%)
		TM helix 5	201..224	CDD:381742	5/26 (19%)
		TM helix 6	251..273	CDD:381742	10/25 (40%)
		TM helix 7	285..310	CDD:381742	5/24 (21%)
		Interaction with SAG. /evidence=ECO:0000269\|PubMed:26200343, ECO:0000269\|PubMed:28753425	330..348
npr-6	NP_509725.2	7tmA_NPYR-like	39..322	CDD:320331	79/302 (26%)
		TM helix 1	40..64	CDD:320331	11/27 (41%)
		TM helix 2	73..95	CDD:320331	9/24 (38%)
		TM helix 3	111..133	CDD:320331	4/21 (19%)
		TM helix 4	159..175	CDD:320331	2/15 (13%)
		TM helix 5	204..227	CDD:320331	5/22 (23%)
		TM helix 6	250..275	CDD:320331	11/24 (46%)
		TM helix 7	290..315	CDD:320331	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910