DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RGS16 and Axn

DIOPT Version :9

Sequence 1:	NP_002919.3	Gene:	RGS16 / 6004	HGNCID:	9997	Length:	202	Species:	Homo sapiens
Sequence 2:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	173	Identity:	36/173 - (20%)
Similarity:	68/173 - (39%)	Gaps:	32/173 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    52 NRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFS--EENLEFWLACEEFKKIRSATKLASRA 114
            ::|.|...|.|..:.:.||..::||..|..:::.|..  .::|.|:.|||..|:.....|:....
  Fly    41 SKNSSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQII 105

Human   115 HQIFEEFICSEAPKEVNIDHETH---ELTRMNLQTATAT-CFDAAQGKTRTLMEKDSYPRFLKSP 175
            ..|: .|:   ...:::|..:..   :..:.|.:...:. .||..|......:..:.||.||.|.
  Fly   106 GAIY-RFL---RKSQLSISDDLRAQIKAIKTNPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSE 166

Human   176 AY----RDLAAQ------------------ASAASATLSSCSL 196
            .|    :.::||                  .|..|:...:|:|
  Fly   167 MYILYIQQMSAQQERCTSSGATGSGSAGSSGSGGSSLAGACAL 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RGS16	NP_002919.3	RGS_RGS16	66..179	CDD:188665	26/122 (21%)
Axn	NP_733336.1	RGS	55..170	CDD:295367	26/118 (22%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810