DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RGS12 and Axn

DIOPT Version :9

Sequence 1:	NP_001381083.1	Gene:	RGS12 / 6002	HGNCID:	9994	Length:	1447	Species:	Homo sapiens
Sequence 2:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	768	Identity:	153/768 - (19%)
Similarity:	254/768 - (33%)	Gaps:	265/768 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   711 SWAVSFERLLQDPVGVRYFSDFLRKEFS--EENILFWQACEYFNHVPAHDKKELSYRAREIFSKF 773
            :||.:...||:|..||..|..::.:|..  .:::.|:.|||....  ..|.:::......|: :|
  Fly    50 NWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ--QTDPEKIKQIIGAIY-RF 111

Human   774 LCSKATTPVNIDSQAQLA-----DDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECIL 833
            | .|:...::.|.:||:.     .::..:||  :|...|..:...::.:.|..||.|.:|   ||
  Fly   112 L-RKSQLSISDDLRAQIKAIKTNPEIPLSPH--IFDPMQRHVEVTIRDNIYPTFLCSEMY---IL 170

Human   834 AEVEGRALPDSQQVPSSPA----SKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRK 894
            ...:..|  ..::..||.|    |..|.||..||::....|...:.||:....:|       ...
  Fly   171 YIQQMSA--QQERCTSSGATGSGSAGSSGSGGSSLAGACALPPTTASGKQQLPQL-------VPP 226

Human   895 GAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSV-------SSAGSLDLSEACRT 952
            |||.:...:..:|                 ...|.|  .:.|||       ||:||:..::   |
  Fly   227 GAFINLPVSSVSG-----------------PPAGTC--SASGSVYGPSTSASSSGSISATD---T 269

Human   953 LAPEKDKATKH--CCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVL 1015
            |.......|.|  ..:.|.|....|...:.|.|:..         |..||.|.    ..|.|:.|
  Fly   270 LPRSSTLPTLHEDSVLSLCDDFEKVQMQEGGGSLGS---------GSVGAGAR----APDYPIRL 321

Human  1016 HQDSSILESRDLRL--EKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRL 1078
                    :|||.:  :||   ||::.|.. :.|....|:...|..:
  Fly   322 --------TRDLLIATQKR---RLEIRPPG-AHGYVYNPSTTNTSYV------------------ 356

Human  1079 SGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSS--------RNHS 1135
                       |.|.:|.:|..:.    |.|:..:|         ..:::|.|        |.||
  Fly   357 -----------PNSRVDSERASVS----SGGRTDSD---------TMSISSCSMDGRPYIQRRHS 397

Human  1136 ATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSN 1200
            :|                 ..|..|...::.:|.:.                   |::|.:.|..
  Fly   398 ST-----------------ESKAIRQSAMANKETNT-------------------FQVIPRTQRL 426

Human  1201 RADDQRGLLRKE--DLVLPEFLRLP-------------PGSTELTLPTPAAVAKGFSKRSATGNG 1250
            .:::.|.|..:|  .|::|:...:.             ||:..||....:|..:.|::..
  Fly   427 HSNEHRPLKEEELVSLLIPKLEEVKRKRDLEERARERNPGAALLTNERSSASDRAFAEAI----- 486

Human  1251 RESASQPGEQWEPVQE-------SSDSPSTSPGSASSPPGPP------------GTTPPGQKSPS 1296
            ||..:...:..:.:.:       ...:|..|||:.|  |.||            |....|..|.|
  Fly   487 REKFALDEDNDQDILDQHVSRVWKDQTPHRSPGTMS--PCPPIPSRRRTATHDSGMVSDGAMSLS 549

Human  1297 G-----------------------PFCTPQSPVSLAQEGTAQIWKRQSQEVEAGGIQT------- 1331
            |                       |.....|.:|:....|...:|..|..   .|..|
  Fly   550 GHSMKHSKSMPDHSSCSRKLTNKWPSMNTDSGISMFSADTVTKYKDASSR---SGSSTASKLEEA 611

Human  1332 ---VEDE-------------HVAELTLMGEGDISSPNSTLLP--PPSTPQEVP 1366
               :|||             |:::..|......||..|..||  ||..|.:.|
  Fly   612 KRRLEDEPRRSRRYAQPPMQHLSQQPLASFSSSSSGGSISLPHQPPPLPAKPP 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RGS12	NP_001381083.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PDZ_signaling	20..96	CDD:238492
		PTB_RGS12	228..359	CDD:269984
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..429
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..482
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..652
		RGS_RGS12	716..830	CDD:188696	28/120 (23%)
		RGS12_us1	836..949	CDD:406910	27/123 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	843..941		23/108 (21%)
		RBD1_RGS12	962..1031	CDD:340656	16/72 (22%)
		Ubiquitin_like_fold	1032..1104	CDD:421700	11/71 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1169		11/73 (15%)
		RGS12_us2	1106..1180	CDD:406908	12/81 (15%)
		GoLoco	1188..1209	CDD:214645	4/20 (20%)
		RGS12_usC	1239..1376	CDD:406909	38/195 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1240..1447		38/194 (20%)
Axn	NP_733336.1	RGS	55..170	CDD:295367	28/123 (23%)
		Axin_b-cat_bind	494..543	CDD:285982	9/50 (18%)
		DIX	665..739	CDD:279160	153/768 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810