Protein Alignment RGS3 and Axn

DIOPT Version :9

• Sequence 1: NP_652759.4
• Gene: RGS3 / 5998
• HGNCID: 9999
• Length: 1094
• Species: Homo sapiens
• Sequence 2: NP_733336.1
• Gene: Axn / 43565
• FlyBaseID: FBgn0026597
• Length: 745
• Species: Drosophila melanogaster
• Alignment Length: 667
• Identity: 133/667 - (19%)
• Similarity: 199/667 - (29%)
• Gaps: 237/667 - (35%)

Human   460 NPARTL--LLSE----ELLLYEGRNKAAEVTLFAYSDLLLF-------TKEDEPGRCDVLRNPLY 511
            |.||||  ||.:    ||.     .|..|....||:|.|.|       .::.:|.:...:...:|
  Fly    50 NWARTLNHLLEDRDGVELF-----KKYVEEEAPAYNDHLNFYFACEGLKQQTDPEKIKQIIGAIY 109

Human   512 LQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKR------------VCWCLSENIAKQ 564
            ....|.|...|:||:..:..:....|  ..|..|..:..:|            ...|....|...
  Fly   110 RFLRKSQLSISDDLRAQIKAIKTNPE--IPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYI 172

Human   565 QQLAASPPDSKMFETEADEKREMALEEG-KGPGAEDSPPSKEPSPGQELPPGQDLPPNKDSPSGQ 628
            ||::|              ::|.....| .|.|:..|    ..|.|..|.....|||.  :.||:
  Fly   173 QQMSA--------------QQERCTSSGATGSGSAGS----SGSGGSSLAGACALPPT--TASGK 217

Human   629 EPAPSQEP----LSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQE-PLPHQ 688
            :..|...|    ::...|:.| |.|.|..:.......|......:..:|....||.... |..|:
  Fly   218 QQLPQLVPPGAFINLPVSSVS-GPPAGTCSASGSVYGPSTSASSSGSISATDTLPRSSTLPTLHE 281

Human   689 DPLLTKDLPAIQESPTRDLPPCQDLPPSQVSLPAKALTEDTMSSG------------DLLAATGD 741
            |.:|:.               |.|....|:.....:|...::.:|            |||.||..
  Fly   282 DSVLSL---------------CDDFEKVQMQEGGGSLGSGSVGAGARAPDYPIRLTRDLLIATQK 331

Human   742 ------PPAAPRPAF--------VIPEVRLDSTYSQKAGAEQG------------CSGD------ 774
                  ||.|....:        .:|..|:|   |::|....|            ||.|
  Fly   332 RRLEIRPPGAHGYVYNPSTTNTSYVPNSRVD---SERASVSSGGRTDSDTMSISSCSMDGRPYIQ 393

Human   775 ---------------------------------------------------------------EE 776
                                                                           ||
  Fly   394 RRHSSTESKAIRQSAMANKETNTFQVIPRTQRLHSNEHRPLKEEELVSLLIPKLEEVKRKRDLEE 458

Human   777 DAEE--------------------AEEVEEGEEGEEDEDEDTSDDNYGERSEAKRSSMIETGQGA 821
            .|.|                    ||.:.|....:||.|:|..|.:      ..|....:|...:
  Fly   459 RARERNPGAALLTNERSSASDRAFAEAIREKFALDEDNDQDILDQH------VSRVWKDQTPHRS 517

Human   822 EGGLSLRVQNSLRRR--THSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWGMPSPSTLKKELGR 884
            .|.:|.......|||  ||..|          ..||..:..| |.....:..||..|:..::|..
  Fly   518 PGTMSPCPPIPSRRRTATHDSG----------MVSDGAMSLS-GHSMKHSKSMPDHSSCSRKLTN 571

Human   885 NGGSMH---HLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAK--DMKNKLGIFRRRNESPGAP 944
            ...||:   .:|:|        .||||....:||.:..|...:|  :.|.:|....||:.....|
  Fly   572 KWPSMNTDSGISMF--------SADTVTKYKDASSRSGSSTASKLEEAKRRLEDEPRRSRRYAQP 628

Human   945 PAGK-ADKMMKSFKPTS 960
            |... :.:.:.||..:|
  Fly   629 PMQHLSQQPLASFSSSS 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RGS3	NP_652759.4	None
Axn	NP_733336.1	RGS	55..170	CDD:295367	24/121 (20%)
		Axin_b-cat_bind	494..543	CDD:285982	15/64 (23%)
		DIX	665..739	CDD:279160

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810