DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RGS1 and Axn

DIOPT Version :9

Sequence 1:	NP_002913.3	Gene:	RGS1 / 5996	HGNCID:	9991	Length:	209	Species:	Homo sapiens
Sequence 2:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	166	Identity:	43/166 - (25%)
Similarity:	80/166 - (48%)	Gaps:	23/166 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    55 RSMIPHLESGMK------SSKSKDVLSAAEVMQWSQSLEKLLANQTGQNVFGSFLKSEFS--EEN 111
            |..:|..||.:|      :..||:  |:...:.|:::|..||.::.|..:|..:::.|..  .::
  Fly    20 RPPVPGEESRVKKMTEGVADTSKN--SSPSYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDH 82

Human   112 IEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQINI--DFRTRESTAKKIKAP-----TPT 169
            :.|:.|||..|: ::|  |.|.::|..|........|::|  |.|.:   .|.||..     :|.
  Fly    83 LNFYFACEGLKQ-QTD--PEKIKQIIGAIYRFLRKSQLSISDDLRAQ---IKAIKTNPEIPLSPH 141

Human   170 CFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLNDLQA 205
            .||..|:.:...:..:.||.||.|::|:..:..:.|
  Fly   142 IFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSA 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RGS1	NP_002913.3	RGS_RGS1	86..199	CDD:188670	33/121 (27%)
Axn	NP_733336.1	RGS	55..170	CDD:295367	33/120 (28%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810