DRSC/TRiP Functional Genomics Resources

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Protein Alignment RGR and AstA-R2

DIOPT Version :9

Sequence 1:NP_002912.2 Gene:RGR / 5995 HGNCID:9990 Length:295 Species:Homo sapiens
Sequence 2:NP_001263042.1 Gene:AstA-R2 / 43393 FlyBaseID:FBgn0039595 Length:357 Species:Drosophila melanogaster


Alignment Length:311 Identity:70/311 - (22%)
Similarity:122/311 - (39%) Gaps:48/311 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    19 VGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALAD-SGISLNALVAATSSLLRVSH 82
            ||....|.|::|...|.|.|........:|:..:|::::||.|| ..:.|.....||..::..  
  Fly    41 VGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYY-- 103

Human    83 RRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRY----HHYCTRSQLAWNSAVSLVLFVWLSS 143
              ||||...|::..:...|||.|||.:...::..|:    |...:|.....|..:..::.:|: .
  Fly   104 --WPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWI-V 165

Human   144 AFWAALPLLGWGH---YDYE-----PLGTC--CTLDYSKGDRNFTSFLFTMSFFNFAMPLFITIT 198
            ....::| :.:.|   .||:     ..|.|  .|.|: .|.|.:....|..|:.   :||.|...
  Fly   166 VLVVSVP-VAFTHDVVVDYDAKKNITYGMCTFTTNDF-LGPRTYQVTFFISSYL---LPLMIISG 225

Human   199 SYSLMEQKLGKSG-----------------HLQVNTTLPARTLLLGWGPYAILYLYA---VIADV 243
            .|..|..:|.:.|                 .|.|...:...:|   |.|..::.|..   ||...
  Fly   226 LYMRMIMRLWRQGTGVRMSKESQRGRKRVTRLVVVVVIAFASL---WLPVQLILLLKSLDVIETN 287

Human   244 TSISPKLQMVPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRT 294
            |.....:|:....:|.....||.:.||..:|...:..::.::...|.::.|
  Fly   288 TLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQNYT 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RGRNP_002912.2 7tmA_Retinal_GPR 17..281 CDD:320200 68/296 (23%)
TM helix 1 18..44 CDD:320200 8/24 (33%)
TM helix 2 51..77 CDD:320200 8/26 (31%)
TM helix 3 92..122 CDD:320200 9/33 (27%)
TM helix 4 130..150 CDD:320200 2/19 (11%)
TM helix 5 177..206 CDD:320200 7/28 (25%)
TM helix 6 208..238 CDD:320200 7/46 (15%)
TM helix 7 248..273 CDD:320200 6/24 (25%)
AstA-R2NP_001263042.1 7tm_4 47..>164 CDD:304433 30/120 (25%)
7tm_1 55..313 CDD:278431 60/270 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147278
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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