DRSC/TRiP Functional Genomics Resources

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Protein Alignment RGR and sro-1

DIOPT Version :9

Sequence 1:NP_002912.2 Gene:RGR / 5995 HGNCID:9990 Length:295 Species:Homo sapiens
Sequence 2:NP_001364737.1 Gene:sro-1 / 191958 WormBaseID:WBGene00005641 Length:380 Species:Caenorhabditis elegans


Alignment Length:328 Identity:64/328 - (19%)
Similarity:123/328 - (37%) Gaps:80/328 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    23 LLVEALSGLSLNTLTIFSFC-----KTPELRTPCHLLVLS-LALADSGISLNALVAATSSLL-RV 80
            |::.|:..|.||.:::....     |...||....|..|. |.:.|..:|...:|...:.|. :.
 Worm    10 LIIFAVVPLLLNLVSLVPIFYRRQQKGKYLRDNASLQPLVWLLIVDVLMSAQLVVPIHNFLTEKG 74

Human    81 SHRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCTRSQLAW---NSAVSLVLFVWLS 142
            :...|     ||..:|......:|..:..:..||:.||....|.....|   ::...|:.|..::
 Worm    75 TFSEW-----GCVVYGAADMTLSLIEVLLACMIAFDRYIVTITPKWGKWRCNSNYFKLIFFGAIA 134

Human   143 SAFWAALPLLGWGHYDYEPLGTCCTLDYSKGD------------RNFTSFLFTMSFFNFAMPLFI 195
            ...|:.:|..|:|.|........|::|:.:|:            ..:.:||.......|.:|:.|
 Worm   135 VGLWSFVPTAGYGKYSTFHHKMFCSIDWRQGNIEPDSEKSRLSAHRYIAFLTATCLVFFLIPVCI 199

Human   196 TIT-SYSLME----QKLGKSGHLQVNTTLPARTLLLGWGP---------------------YAIL 234
            ..: .||:::    |...:|   |:...:| :..:..|.|                     |:|:
 Worm   200 ASSLYYSIIDHVDSQNASES---QLENGIP-KPEVCTWAPKNHVGKVGLGCLLVSVVPFFAYSIV 260

Human   235 YLYAVIADVTSISPKLQMVPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQ---------KRE 290
            .|..:.::...|  ...::|.:::::...:|.|.|          :|  |:|:         ||.
 Worm   261 CLNPMKSNFHQI--HYIVIPVIVSRVSTLLNPIFY----------VW--LNPEIIPINEFIAKRA 311

Human   291 KDR 293
            |.|
 Worm   312 KPR 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RGRNP_002912.2 7tmA_Retinal_GPR 17..281 CDD:320200 57/305 (19%)
TM helix 1 18..44 CDD:320200 5/25 (20%)
TM helix 2 51..77 CDD:320200 6/26 (23%)
TM helix 3 92..122 CDD:320200 7/29 (24%)
TM helix 4 130..150 CDD:320200 3/19 (16%)
TM helix 5 177..206 CDD:320200 7/33 (21%)
TM helix 6 208..238 CDD:320200 8/50 (16%)
TM helix 7 248..273 CDD:320200 4/24 (17%)
sro-1NP_001364737.1 7tm_GPCRs 10..300 CDD:421689 60/312 (19%)
TM helix 1 10..32 CDD:410628 5/21 (24%)
TM helix 3 81..111 CDD:410628 7/29 (24%)
TM helix 4 122..142 CDD:410628 3/19 (16%)
TM helix 5 169..211 CDD:410628 7/41 (17%)
TM helix 6 234..264 CDD:410628 4/29 (14%)
TM helix 7 274..297 CDD:410628 5/34 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
10.960

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