Protein Alignment RGR and sro-1

DIOPT Version :10

• Sequence 1: NP_002912.2
• Gene: RGR / 5995
• HGNCID: 9990
• Length: 295
• Species: Homo sapiens
• Sequence 2: NP_001364737.1
• Gene: sro-1 / 191958
• WormBaseID: WBGene00005641
• Length: 380
• Species: Caenorhabditis elegans
• Alignment Length: 328
• Identity: 64/328 - (19%)
• Similarity: 123/328 - (37%)
• Gaps: 80/328 - (24%)

Human    23 LLVEALSGLSLNTLTIFSFC-----KTPELRTPCHLLVLS-LALADSGISLNALVAATSSLL-RV 80
            |::.|:..|.||.:::....     |...||....|..|. |.:.|..:|...:|...:.|. :.
 Worm    10 LIIFAVVPLLLNLVSLVPIFYRRQQKGKYLRDNASLQPLVWLLIVDVLMSAQLVVPIHNFLTEKG 74

Human    81 SHRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCTRSQLAW---NSAVSLVLFVWLS 142
            :...|     ||..:|......:|..:..:..||:.||....|.....|   ::...|:.|..::
 Worm    75 TFSEW-----GCVVYGAADMTLSLIEVLLACMIAFDRYIVTITPKWGKWRCNSNYFKLIFFGAIA 134

Human   143 SAFWAALPLLGWGHYDYEPLGTCCTLDYSKGD------------RNFTSFLFTMSFFNFAMPLFI 195
            ...|:.:|..|:|.|........|::|:.:|:            ..:.:||.......|.:|:.|
 Worm   135 VGLWSFVPTAGYGKYSTFHHKMFCSIDWRQGNIEPDSEKSRLSAHRYIAFLTATCLVFFLIPVCI 199

Human   196 TIT-SYSLME----QKLGKSGHLQVNTTLPARTLLLGWGP---------------------YAIL 234
            ..: .||:::    |...:|   |:...:| :..:..|.|                     |:|:
 Worm   200 ASSLYYSIIDHVDSQNASES---QLENGIP-KPEVCTWAPKNHVGKVGLGCLLVSVVPFFAYSIV 260

Human   235 YLYAVIADVTSISPKLQMVPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQ---------KRE 290
            .|..:.::...|  ...::|.:::::...:|.|.|          :|  |:|:         ||.
 Worm   261 CLNPMKSNFHQI--HYIVIPVIVSRVSTLLNPIFY----------VW--LNPEIIPINEFIAKRA 311

Human   291 KDR 293
            |.|
 Worm   312 KPR 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RGR	NP_002912.2	7tmA_Retinal_GPR	17..281	CDD:320200	57/305 (19%)
		TM helix 1	18..44	CDD:320200	5/25 (20%)
		TM helix 2	51..77	CDD:320200	6/26 (23%)
		TM helix 3	92..122	CDD:320200	7/29 (24%)
		TM helix 4	130..150	CDD:320200	3/19 (16%)
		TM helix 5	177..206	CDD:320200	7/33 (21%)
		TM helix 6	208..238	CDD:320200	8/50 (16%)
		TM helix 7	248..273	CDD:320200	4/24 (17%)
sro-1	NP_001364737.1	7tm_GPCRs	10..300	CDD:475119	60/312 (19%)
		TM helix 1	10..31	CDD:410628	5/20 (25%)
		TM helix 3	82..104	CDD:410628	3/21 (14%)
		TM helix 4	126..142	CDD:410628	3/15 (20%)
		TM helix 5	170..205	CDD:410628	5/34 (15%)
		TM helix 6	240..262	CDD:410628	2/21 (10%)
		TM helix 7	274..297	CDD:410628	5/34 (15%)