DRSC/TRiP Functional Genomics Resources

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Protein Alignment RGR and npr-5

DIOPT Version :9

Sequence 1:NP_002912.2 Gene:RGR / 5995 HGNCID:9990 Length:295 Species:Homo sapiens
Sequence 2:NP_001024265.1 Gene:npr-5 / 190386 WormBaseID:WBGene00021983 Length:433 Species:Caenorhabditis elegans


Alignment Length:329 Identity:57/329 - (17%)
Similarity:110/329 - (33%) Gaps:104/329 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    22 VLLVEALSGLSLNTLT-------IFSF--------------------CKTPELRTPCHLLVLSLA 59
            :.:.||::...::.:|       ||:|                    .:...|::..::.:|:|.
 Worm    34 IQIAEAIAAQGIDDITVDFYIRSIFTFLYGFLFVLGIFGNGGVLWAVARNKRLQSARNVFLLNLI 98

Human    60 LAD-----SGISLNALVAATSSLLRVSHRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWG--- 116
            ..|     :.|.:....|.|        :.|.:||..|.       :..|::.||....:|.   
 Worm    99 FTDLILVFTAIPVTPWYAMT--------KDWAFGSVMCH-------LVPLSNSCSVFVTSWSLTA 148

Human   117 ----RYHHY--CTRSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYD----YEP-----LGTCC 166
                ::.|.  .|:..::...|:::...:|:.|.......|:.:.|.|    .:|     .|..|
 Worm   149 ISLDKFLHINDPTKQPVSIRQALAITFLIWIVSTLINLPYLMSFEHVDGSFYVQPGETPYCGHFC 213

Human   167 TLDYSKGDRNFTSFLFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQ-----VNTTLPARTLLL 226
            .....:.:.:...:..|:....|.:|:.:....|..:.||:.|...:|     .:.|...|    
 Worm   214 DEANWQSENSRKIYGTTVMLLQFVVPMAVITYCYFKILQKVSKDMIIQNAQFCQSLTQKQR---- 274

Human   227 GWGPYAILYLYAVIADVTSISPKLQMVPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREK 291
                          :|.||...|:..:  |||.:|..|              |.|..|:.....|
 Worm   275 --------------SDATSRKKKVNYI--LIAMVVTFI--------------GCWLPLTLLNLVK 309

Human   292 DRTK 295
            |..|
 Worm   310 DFKK 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RGRNP_002912.2 7tmA_Retinal_GPR 17..281 CDD:320200 52/313 (17%)
TM helix 1 18..44 CDD:320200 6/48 (13%)
TM helix 2 51..77 CDD:320200 6/30 (20%)
TM helix 3 92..122 CDD:320200 6/38 (16%)
TM helix 4 130..150 CDD:320200 3/19 (16%)
TM helix 5 177..206 CDD:320200 4/28 (14%)
TM helix 6 208..238 CDD:320200 4/34 (12%)
TM helix 7 248..273 CDD:320200 6/24 (25%)
npr-5NP_001024265.1 7tmA_NPYR-like 56..347 CDD:320331 54/307 (18%)
TM helix 1 58..82 CDD:320331 2/23 (9%)
TM helix 2 91..113 CDD:320331 4/21 (19%)
TM helix 3 129..151 CDD:320331 4/28 (14%)
TM helix 4 172..188 CDD:320331 2/15 (13%)
TM helix 5 225..248 CDD:320331 3/22 (14%)
TM helix 6 282..307 CDD:320331 9/40 (23%)
TM helix 7 323..347 CDD:320331
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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