Protein Alignment RFX3 and Rfx

DIOPT Version :10

• Sequence 1: XP_054219441.1
• Gene: RFX3 / 5991
• HGNCID: 9984
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Alignment Length: 781
• Identity: 338/781 - (43%)
• Similarity: 433/781 - (55%)
• Gaps: 181/781 - (23%)

Human    31 MQTSETGSDTGSTVTLQT---SVASQAAVP--TQVVQQVPVQQQVQQVQTVQ------------- 77
            |.|..|....|:|||...   |:|..||:.  ..:.||| ...||..|||.:
  Fly   149 MGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQV-ANGQVTVVQTTEDDDGTPFITVTVS 212

Human    78 -QVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHS 141
             |.|:.   |||||: |:..::|.:....|||:.....|..|....|:.|.|
  Fly   213 GQEQNY---QVQYVD-SELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTG------------- 260

Human   142 MVGTGGIQMGVTGGQLISSSGGT----------YLI----GNSMENSGHSVTHTT-----RASP- 186
                   |.|.|     ||:||:          ||:    |..:..|.||::.:.     |.||
  Fly   261 -------QYGTT-----SSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPH 313

Human   187 ---------------------------ATIEMAIETLQ-KSDGLSTHRSS--------------- 208
                                       |.|:.|..|.| .:...:||.:|
  Fly   314 SLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDS 378

Human   209 ----------LLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIF 263
                      :.::.::||..|||||:|||||||||||||::||.||||:|||||||||||||:|
  Fly   379 DQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVF 443

Human   264 MGLRTRRLGTRGNSKYHYYGIRVKPDSPLN-RLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADG 327
            .|||||||||||||||||||||:||.|.|| :..:|.|.:|....|.               :||
  Fly   444 SGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPS---------------SDG 493

Human   328 FTGSGQQTGTSVEQTVIAQ-----------SQHHQ-----------------QFL-DASRALPEF 363
            ..|.|.....||..:...|           .|.|.                 |:: |.:.|||.|
  Fly   494 TGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSF 558

Human   364 GEVEIS-SLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTI 427
            ..:|:: |.....|.||:.:.:.|||||||:.||.|:||:|:.:|.|.:.|||.|
  Fly   559 PPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRAS---------- 613

Human   428 TESSNLSEIESR--LPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIR 490
             :::||.|.|..  |.|.||..||....:.|::...|:..||..|:::||||||.||:|||||||
  Fly   614 -DNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIR 677

Human   491 NFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD 555
            ||||:||.||..:|..:|:::.|.|.:|||||.||||||||||||||||||||||.:||:|||||
  Fly   678 NFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSD 742

Human   556 LNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSF 620
            ||||||.||||||:||.||...:|||||:|||..|||||:|||||:||..|:..|::.|.|:|::
  Fly   743 LNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTY 807

Human   621 PKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMG 685
            .:|||||||||||||||:|||||||||:|||||||||||:||||||||||::|:|..:|.|||:.
  Fly   808 ARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVIC 872

Human   686 E 686
            |
  Fly   873 E 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RFX3	XP_054219441.1	RFX1_trans_act	<81..168	CDD:461362	24/100 (24%)
		RFX_DNA_binding	214..288	CDD:460512	61/73 (84%)
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	61/75 (81%)