Protein Alignment RFX3 and CG9727

DIOPT Version :10

• Sequence 1: XP_054219441.1
• Gene: RFX3 / 5991
• HGNCID: 9984
• Length: 808
• Species: Homo sapiens
• Sequence 2: NP_001262317.1
• Gene: CG9727 / 40794
• FlyBaseID: FBgn0037445
• Length: 1329
• Species: Drosophila melanogaster
• Alignment Length: 851
• Identity: 147/851 - (17%)
• Similarity: 247/851 - (29%)
• Gaps: 391/851 - (45%)

Human    48 TSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQ-------HVYPAQVQYVEGSDTVYTNGAIRTT 105
            |..|:.||....|...:|:.|.:.....:|:..       .:.||.:.|   |.|.:...||...
  Fly    13 TKSAAPAATTAPVSNSIPIPQPIPVALPLQKPNANPYGNCSLQPADIVY---SATRFQGPAIHAK 74

Human   106 TYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMV------------------GTGGI---- 148
            ..|.|.|.:  ...||     ..:|||::....:|..|                  .:||:
  Fly    75 GSPLTITPV--GPVGG-----APASAQISPTSHTHVPVPVATPSGFVPPPFSNATSASGGVSTSV 132

Human   149 ----------------------------QMGVTGGQLISSSGGTYL------------------- 166
                                        |:|:  |:::.:.||...
  Fly   133 LTPNPFATASANAAGLAFANAFSFSTAQQLGL--GKIMHAMGGATAGVPSAPVPVTTTPATAAPS 195

Human   167 ----------------------------IGNSMENSGHSVTHTTRASPATIEMAIET-------- 195
                                        :.|::.||..:.:..:......:...|||
  Fly   196 TPTIAGPRHPNEGVPAASGVINSTIAENVMNALSNSNSAGSVPSEEKMRRVLQVIETSLDDNAKL 260

Human   196 -----LQKSDGLSTHRS---------------------------SLLNSHLQWLLDNYETAEGVS 228
                 |::..||.....                           |.:|..:.|:..:.|....||
  Fly   261 QISQILERVSGLKPIEKLFLYLRLPGECADTDPLRQPQNPLGTRSEINHTINWVRSHLEHDAQVS 325

Human   229 LPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIR-----VKP 288
            :|:..:||.|:.:|:...:.|::.|.|||:::.:|.|:|.|||||||||:|.|..:|     ..|
  Fly   326 IPKQDVYNDYIAYCERLSIKPLSTADFGKVMKQVFPGVRPRRLGTRGNSRYCYAAMRKTTKLTPP 390

Human   289 DSP-------------------------------------------------LNRLQEDMQYMAM 304
            ..|                                                 ||...|.:..::.
  Fly   391 QLPQLCKTEQIVAGDSNSDPSQLTSASSLGGLPSTGGDSECWDVVRSWAEKLLNTKLESVADLSS 455

Human   305 R---------------QQPMQQ---------KQRYKPMQKVDGVADGFTGS---------GQQTG 336
            |               ::|.::         |:|.|..:|      |.|.|         ||..|
  Fly   456 RIKSNNATVSTKKYTPREPKEKRVLADIGPLKKRRKKKRK------GSTSSESSCNQLVTGQDAG 514

Human   337 TS----------VEQTVIAQSQHHQQ----FL---------------DASRALP----EFG---- 364
            :|          ::|.:|....|.||    :|               .|.|.|.    |.|
  Fly   515 SSQEASDEQILKIKQEIIDSPIHPQQPPIGYLQQVTPMNLATDQRSSSAVRNLTPKILEMGSPAV 579

Human   365 ---EVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQT--FWRYSPSTPTDG 424
               :.|:|  |.|...:|             .:.|...|:....:.|..||  ||..|||:   |
  Fly   580 VLTQQEVS--PTGIVIKD-------------EVEDYTSNIFCKKVLKAQQTKGFWANSPSS---G 626

Human   425 TTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLR------PIPS 483
            ||                                         :.|.:|:|..:.      |.|:
  Fly   627 TT-----------------------------------------SGVGLLVPPTITTTSATPPPPN 650

Human   484 ALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHL----------AQA 538
            :.|..:.....|:         ..|.:|:.|...:.|:...|..:..|.|.:          |:.
  Fly   651 SETSPVPGPGLSM---------GPPSQMMSTSSVSPSSTVDTTPKVASRNQMMILRAKRLMAAEN 706

Human   539 ARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWL 603
            |.......|.:.:.|. |.|       |:...:|..|.:.:.    |:.:..:.:...|:    .
  Fly   707 AALAAAEDSGLPENLG-LPR-------ERVISICNMDKHELD----DYFLPGEDEENSEE----P 755

Human   604 DNVMMQ 609
            ||.::|
  Fly   756 DNELLQ 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RFX3	XP_054219441.1	RFX1_trans_act	<81..168	CDD:461362	24/183 (13%)
		RFX_DNA_binding	214..288	CDD:460512	29/78 (37%)
CG9727	NP_001262317.1	PHA03247	<40..207	CDD:223021	25/178 (14%)
		RFX_DNA_binding	307..385	CDD:460512	30/77 (39%)