DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RFC1 and Gnf1

DIOPT Version :9

Sequence 1:NP_001191676.1 Gene:RFC1 / 5981 HGNCID:9969 Length:1148 Species:Homo sapiens
Sequence 2:NP_001014605.1 Gene:Gnf1 / 40607 FlyBaseID:FBgn0004913 Length:1008 Species:Drosophila melanogaster


Alignment Length:1038 Identity:420/1038 - (40%)
Similarity:574/1038 - (55%) Gaps:137/1038 - (13%)


- Green bases have known domain annotations that are detailed below.


Human   185 KRKELSQNTDESGLNDEAIA----KQLQLDEDAELERQLHEDEEFARTLAMLDEEPKTKKARKDT 245
            :||.:..::||    ||.::    |:.:..:.|.     .||:..|.|     .||..||||...
  Fly    33 RRKAVIISSDE----DEVVSPPETKKRKASKTAS-----SEDDVVAAT-----PEPIAKKARNGQ 83

Human   246 EAGETFSSVQANLSKAEKHKYP-------------HKVKTAQVSDERKSYSPRK-------QSKY 290
            :..         |||.::|..|             .|.||..|.:.......|.       :|..
  Fly    84 KPA---------LSKLKRHVDPTELFGGETKRVIVPKPKTKAVLEFENEDIDRSLMEVDLDESIK 139

Human   291 ESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKENAIKLKGETKTPK 355
            |::.|.:.||.:.       |||..       ||.:.||.:..:|.::|.|         ..||:
  Fly   140 EAAPEKKVHSITR-------SSPSP-------KRAKNSSPEPPKPKSTKSK---------ATTPR 181

Human   356 KTKSSPAK--KESV--SPEDSEKKRTNYQAYRSYLNREGPKALGSKEIPKGAENCLEGLIFVITG 416
            ..|..||.  :.||  ..|..|:||.:...|:.|.||......||||||||:.:||.||.||:||
  Fly   182 VKKEKPAADLESSVLTDEERHERKRASAVLYQKYKNRSSCLNPGSKEIPKGSPDCLSGLTFVVTG 246

Human   417 VLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRDSGQSKSDKAAALGTKIIDEDGLLNLIRT 481
            ||||:||:||:|:|:.|||||...|.||..|||:|.::|..|...|..|...|:.||||.:|||.
  Fly   247 VLESMEREEAESVIKEYGGKVMTVVGKKLKYLVVGEEAGPKKLAVAEELNIPILSEDGLFDLIRE 311

Human   482 MPG--KKSKYEIAVETEMKKESKLERTPQKNVQGKRKISPSKKESESKKSRPTSKRDSLAKTIKK 544
            ..|  |:.|.|   :...|||...|...:|.|:..|: |..|||.|:.|.:...|.|.....:|:
  Fly   312 KSGIAKQVKEE---KKSPKKEHSSEEKGKKEVKTSRR-SSDKKEKEATKLKYGEKHDIAKHKVKE 372

Human   545 E-----------TDVFWKSLDFKEQVAEETSGDSKARNLADDSSENKVENLLWVDKYKPTSLKTI 598
            |           .||...:|..|::.:.:.......|..  |.....|..:.||||:||||:|.|
  Fly   373 EHTSPKETKDKLNDVPAVTLKVKKEPSSQKEHPPSPRTA--DLKTLDVVGMAWVDKHKPTSIKEI 435

Human   599 IGQQGDQSCAN----------------------KLLRWLRNWQKSSSEDKKHAAKFGKFSGKDDG 641
            :||.|..|...                      :|:.||..|..:...:|| ..:...::..|||
  Fly   436 VGQAGAASNVTNHNLKLKAKQERVKVLHYFNFPRLMNWLSKWYVNHDGNKK-PQRPNPWAKNDDG 499

Human   642 SSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSNG 706
            |.:||||||||||:||||||:||.:|||:..||.||||||||..||..|:..|:|.|:.|::: |
  Fly   500 SFYKAALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLSGYFT-G 563

Human   707 AASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRNHPKIRSLVHYCFDLR 771
            ...:||.||.|||||||||||||||||:||||.|||.:.|||||||||||||||||||:||:|||
  Fly   564 QGQAVSRKHVLIMDEVDGMAGNEDRGGMQELIALIKDSSIPIICMCNDRNHPKIRSLVNYCYDLR 628

Human   772 FQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCARSKALTYDQAKAD 836
            |||||:|||||.:|||.|||.:||.|..:.|||...|.||||.::::::..|:..|    ..|:.
  Fly   629 FQRPRLEQIKGKIMSICFKEKVKISPAKVEEIIAATNNDIRQSINHIALLSAKEDA----SQKSG 689

Human   837 SHRAKKDIKMGPFDVARKVFAAGEETAHMSLVDKSDLFFHDYSIAPLFVQENYIHVKPVAAGGDM 901
            ...|.||:|:||::|.||||.| :|..|||..|||||||||||:||||||:||:.|.|   .|:.
  Fly   690 QQVATKDLKLGPWEVVRKVFTA-DEHKHMSFADKSDLFFHDYSLAPLFVQQNYLQVLP---QGNK 750

Human   902 KKHLMLLSRAADSICDGDLVDSQIRSKQNWSLLPAQAIYASVLPGELMRGYMTQFPTFPSWLGKH 966
            |..|..::..||::..||||:.:||:...|||||.||.::||||||.|.|:.|....||.||||:
  Fly   751 KDVLAKVAATADALSLGDLVEKRIRANSAWSLLPTQAFFSSVLPGEHMCGHFTGQINFPGWLGKN 815

Human   967 SSTGKHDRIVQDLALHMSLRTYSSKRTVNMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLM 1031
            |.:||..|:.|:|..|..:.|..|:.:|.:||...|.|.:|:||...|.:||...:.:|..|:|:
  Fly   816 SKSGKRARLAQELHDHTRVCTSGSRLSVRLDYAPFLLDNIVRPLAKDGQEGVPAALDVMKDYHLL 880

Human  1032 KEDFENIMEISSWGGKPSPFSKLDPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEY- 1095
            :||.::::|::||.||.||...:|.:||||.||:||||.....||.||....:.|.:...|.:| 
  Fly   881 REDLDSLVELTSWPGKKSPLDAVDGRVKAALTRSYNKEVMAYSYSAQAGIKKKKSEAAGADDDYL 945

Human  1096 NEELNEDD------SQSDEKDQDAIETDAMIKKK-----TKSSKPSKPEKDKEPRKGKGKSSK 1147
            :|...|:|      |..:::|:|.:|.|::||.|     :|:|..||........|.|.|:.|
  Fly   946 DEGPGEEDGAGGHLSSEEDEDKDNLELDSLIKAKKRTTTSKASGGSKKATSSTASKSKAKAKK 1008

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RFC1NP_001191676.1 Neuromodulin_N <14..404 CDD:331332 66/246 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..201 4/15 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 228..380 43/175 (25%)
COG5275 272..502 CDD:227600 90/242 (37%)
LIGANc <392..479 CDD:332121 47/86 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..538 15/41 (37%)
RuvB_N 584..>1003 CDD:330522 227/440 (52%)
RFC1 915..1067 CDD:312129 67/151 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1081..1148 22/79 (28%)
Nuclear localization signal. /evidence=ECO:0000255 1120..1124 3/8 (38%)
Gnf1NP_001014605.1 COG5275 <151..358 CDD:227600 92/233 (39%)
BRCT 232..309 CDD:278934 40/76 (53%)
PRK04195 421..969 CDD:235250 270/557 (48%)
AAA 506..633 CDD:278434 91/127 (72%)
RFC1 764..917 CDD:285691 68/152 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157758
Domainoid 1 1.000 155 1.000 Domainoid score I4237
eggNOG 1 0.900 - - E1_COG5275
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2187
Inparanoid 1 1.050 661 1.000 Inparanoid score I770
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52880
OrthoDB 1 1.010 - - D291910at33208
OrthoFinder 1 1.000 - - FOG0003699
OrthoInspector 1 1.000 - - oto91616
orthoMCL 1 0.900 - - OOG6_101059
Panther 1 1.100 - - LDO PTHR23389
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1087
SonicParanoid 1 1.000 - - X3601
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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