DRSC/TRiP Functional Genomics Resources

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Protein Alignment REV3L and DNApol-zeta

DIOPT Version :9

Sequence 1:XP_011534330.1 Gene:REV3L / 5980 HGNCID:9968 Length:3157 Species:Homo sapiens
Sequence 2:NP_524881.2 Gene:DNApol-zeta / 47186 FlyBaseID:FBgn0002891 Length:2130 Species:Drosophila melanogaster


Alignment Length:3241 Identity:887/3241 - (27%)
Similarity:1297/3241 - (40%) Gaps:1210/3241 - (37%)


- Green bases have known domain annotations that are detailed below.


Human     1 MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPY 65
            ::|||:|.||:||..|..|:|.|.|.|....:|:|||:||||....|||||:|:||:|||||:||
  Fly    11 VYSVRLVIADFYMEKPQFGMDPCYSELRGKEIKRVPVIRVFGGNSRGQKTCMHVHGVFPYLYIPY 75

Human    66 DGYG-QQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYN 129
            |... :..|..:.|||..:|:|:|::||..||.||||||:.||.|:||||||..|..|:|||::|
  Fly    76 DKKDFESLERGILQMAMHLDKAINISLGQGSSNAQHVFKIQLVKGIPFYGYHRVEHQFLKIYMFN 140

Human   130 PTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLIN--LAAVKFRKARRKSNTL 192
            |..|:|...|||||||::|.:.|||:|:||:||..||||||||:.::  |..:|||         
  Fly   141 PRFVRRAANLLQSGAILSKNFSPHESHVPYILQFMIDYNLYGMSYVHVPLEVLKFR--------- 196

Human   193 HATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEG------VEPQSTCE-LEVDAVAADILNRLD 250
                  :||             :.|.||.:.:.:.      ...:..|. ||||..:..||||..
  Fly   197 ------RNH-------------DDDVIPYANVKQAQLLDITTAKKVACSALEVDVSSNFILNRFQ 242

Human   251 IEAQIGG---NPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQN 312
            :.|:...   |||::|||.|||.||:...| ......:.:....||..|.... |:|.|..:.::
  Fly   243 LVAKSKSNHTNPGIEAIWNDEKLRRQKLVE-KHTDAGDEEKAEAVPVLELPPT-QERHQIEIAES 305

Human   313 DFSVRTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKDKESSKGHTRHKVEEAL 377
            |...||                  .|.|::::                            :|::.
  Fly   306 DIFYRT------------------ALESKLMT----------------------------LEQST 324

Human   378 INEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAGLESDGYRGERNRMPSPCRSFG 442
            ::|:.:     :.||..|.....:..|                     |.:.::.|. :..:...
  Fly   325 LSEQTL-----SDQTILPQATMQTTMP---------------------GTKAQKRRF-NLQKLLA 362

Human   443 NNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEH--CAKKRSLCRNTHRSSTED-DDSSS 504
            |..||:....::.:..:..              |.|:.|  |....|:..:|.:..::| |::..
  Fly   363 NAVYPEECSQDQQQLLVNA--------------SFIQNHVTCGYSSSVSLSTSKDESDDLDETVV 413

Human   505 GEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNENSRTHSSVIATSKLSVKPSIFHKDAATLE 569
            .||        |:.||:.|                     |.::                     
  Fly   414 DEE--------LILSLTQP---------------------HGAI--------------------- 428

Human   570 PSSSAKITFQCKHTSALSSHVLNKEDLIEDLSQTNKNTEKGLDNSVTSFTNESTYSMKYPGSLSS 634
                       .|.:.|....|...|.::.|.:.|: :|..:|                   |.|
  Fly   429 -----------PHDATLREEDLELLDALQLLEEQNE-SESHVD-------------------LDS 462

Human   635 TVHSENSHKENSKKEILP-----VSSCESSIFDYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHM 694
            ::...:.||   |.|:.|     .::..:::||  ||:.|                ::|:     
  Fly   463 SLAPLSQHK---KFELTPELLDKETAATAALFD--EDVDS----------------DEDA----- 501

Human   695 HRHPNENTLGKNSFNFSDLNHSKNKVSSEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVH 759
                                                                    ..|.|   |
  Fly   502 --------------------------------------------------------DQETR---H 507

Human   760 SLNSTADESGLNKLKIRYEEFQEHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQP 824
            ..::..|:.....||:...:..|.|..|.|                       .||..:      
  Fly   508 DFSTVLDDVDELLLKLTQSQPAESKELKAS-----------------------SKLPQI------ 543

Human   825 GNKPSRLKLNKRKLAGHQETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENK 889
                                        ...|:.:|..|..|...|..:..|            |
  Fly   544 ----------------------------DGADDRLQRTPIKSISSKSKSSPS------------K 568

Human   890 TPTDGFIDCHFGDGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGE 954
            |||                                                              
  Fly   569 TPT-------------------------------------------------------------- 571

Human   955 SLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLA 1019
                              .|:           |:|::                            
  Fly   572 ------------------TPI-----------GQKSL---------------------------- 579

Human  1020 PLKDFWPKVPDSPAT----KYPIYPLTPKKSHRRKSKHKSAKKKTGKQ------QRTNNENIKRT 1074
                  ||.|.:|.|    ||....||...|..:||..:.|.:.:..:      |.|....::..
  Fly   580 ------PKSPRTPKTSAAKKYAPLALTIGSSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPE 638

Human  1075 LSFRKKRSHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEE 1139
            :|.|||                                                           
  Fly   639 ISLRKK----------------------------------------------------------- 644

Human  1140 IMAAAEKEAMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKLVDD 1204
             :|.:|.....|:...|..|...:.:..|.|:.:.:.|:....   |:..:.||.........:|
  Fly   645 -LAMSEMRRKSFEDSFVLLKNDCTPVRSTRRSTSNLDKTHIIC---SLTPRDRNPGLSDMFETED 705

Human  1205 GKKKPRAK--QKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQLLFKQKD 1267
            ||:.|..|  :||                         ::..::|::.                 
  Fly   706 GKQLPPKKVVRKT-------------------------RWSTRNQDIE----------------- 728

Human  1268 MPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHPSVVCNSIGPGV 1332
                          |||.        :||                                    
  Fly   729 --------------SLPK--------AGC------------------------------------ 735

Human  1333 SKINVQRPHNQ--SAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGMSSKIEDNANNIQRNYL 1395
               .::|||..  ||:..||.                                            
  Fly   736 ---EIERPHRSEGSALDELKP-------------------------------------------- 753

Human  1396 SSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSETCSPGNTASEESQMPNNCF 1460
                     |.|...|::.| .|:               |.|...:|..|..|            
  Fly   754 ---------RRSARHKVNSA-NPD---------------ECSSEIQTTGPRVT------------ 781

Human  1461 VTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKA-LSQCKNRNVSTPSAFGEG 1524
            .|||..|                                   |.|| |||....|..|      .
  Fly   782 TTSLDRP-----------------------------------QKKARLSQSPKENTKT------S 805

Human  1525 QSGLAVLKELLQKRQQKAQNANTTQDPLSNK---HQPNKNISGSLEHNKANKRTRSVTSPRKPRT 1586
            .:|...|::             .|:|..||.   ||...::|..:|:.::..:....|:    |:
  Fly   806 MNGTVALEK-------------ATKDSSSNSESPHQQENSVSEQIEYLESKPKKSDETA----RS 853

Human  1587 PRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDSPIFFSDPGFESCYSLED-SLSPEHNYNFDI 1650
            .....|:|.||:                      .|...| || :|..|.|: :.||.|:     
  Fly   854 CDEKLQRELIPQ----------------------EPAGIS-PG-DSANSTEEITFSPCHD----- 889

Human  1651 NTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIE---KNEFLSHDNQKCDEDKHHT 1712
                                                   :|||   :::::....:|....|.  
  Fly   890 ---------------------------------------EAIESDTESDYIVTKLRKTPNLKR-- 913

Human  1713 TDSASW-IRSGTLSPEIFEKSTIDSNENRRHNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKS 1776
               ..| |||..|:.:....|.|...|.....|       |:.:||.              |...
  Fly   914 ---LRWSIRSELLNKQFTPSSGIRPPETETTPQ-------LSPKSNE--------------SNTP 954

Human  1777 RLNRSSVSKEVFLSLPQPNNSDWIQGHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELY 1841
            .|.||.....:.::.|                        :.|:..|.||            |::
  Fly   955 ELMRSFYEHSLIVNSP------------------------SVFSDFLDSP------------EIH 983

Human  1842 VSRNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLSETIYQ 1906
            :            .|||| :.||...| ||      ::.||..|||.:|:::.....|:.|..:|
  Fly   984 M------------DSPRS-APPSPDSN-SF------VIAPLELPPSYDEVVSGSRKMDIPEYEFQ 1028

Human  1907 EPFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLE-GLRLWK------TAFSAMTQNP 1964
            :|:.|||||| .|..|:|..:|.:.....||...|:.....: ||..|:      ....||.|..
  Fly  1029 KPYYSNPSDV-SKVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWRRRQLIAIGGLAMLQRH 1092

Human  1965 RPGSPLRSGQGVVNKGSSNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPT 2029
            |       |:..|.:..|.      .::|.|.|.:.||:.|..::||:|| |..|.::.||    
  Fly  1093 R-------GEQKVREYFST------QQRIAIEPAQLAPTWQEAKIWLKAK-ELLRQREEPK---- 1139

Human  2030 GVVKSAENFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQM 2094
               ||:::.       |.|:...:..::                  :.|||              
  Fly  1140 ---KSSDDI-------DSPIKIKRQKIT------------------MMLQA-------------- 1162

Human  2095 LPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFE 2159
                         |:.|..                           :||:...   |||..    
  Fly  1163 -------------EEGDGG---------------------------SGDEDAG---EELDC---- 1180

Human  2160 NFLKPIKDGIQKSPCSEPQEPLVISPINTRAR-TGKCESLCFHSTPIIQRKLLERLPEAPGLSPL 2223
                    .:..:|.|:.::....:|.:::|| |||                 .||.....||.:
  Fly  1181 --------SLSLTPLSQAKDKCKATPTSSKARETGK-----------------SRLKRGTRLSFI 1220

Human  2224 STEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETS------QIDGPS---------- 2272
            .::.:....|                |:..|..:.:..|.|..      |::|.|          
  Fly  1221 GSQDEEPPSS----------------QSSEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFG 1269

Human  2273 -----LNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSD 2332
                 |:||:||||:::|||:|||..:..:||:|::|:...||.||:|||..|.|..|||.|  :
  Fly  1270 LSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMHDEIRCLFYAI--E 1332

Human  2333 TPLPDTEK--TELTGVIVIDKDKTVFSQDIRYQTPLLIRSGI-TGLEVTYAADEKALFHEIANII 2394
            ..||| ||  ::..|.|:::   ||  ||:..:.|.   .|| ..:||.....|...|..:..:.
  Fly  1333 HSLPD-EKLPSKACGYIMVN---TV--QDLLSEGPF---HGIDRDIEVQVVTSEAEAFEALLALC 1388

Human  2395 KRGCHQHVRCFQYPHFFYFCKQLRERNMYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRV 2459
            :|                          :|.||..||||:|.||||::.||..|..::..::|||
  Fly  1389 ER--------------------------WDADIYAGYEIEMSSWGYVIDRAKHLCFNIAPLLSRV 1427

Human  2460 PDDKIENRFAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFT 2524
            |..|:.:....:|:::....: |:.:.|||.|::||:||:|:|||:||||||.:|:||:|.|..|
  Fly  1428 PTQKVRDFVDEDREQFTDLDV-EMKLCGRILLDVWRLMRSEIALTSYTFENVMYHILHKRCPWHT 1491

Human  2525 FRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYR 2589
            .:.|::||.:...  ||.::::|:.||||.|.:|:||||:|:|||||:|.||||..||:||||:|
  Fly  1492 AKSLTEWFGSPCT--RWIVMEYYLERVRGTLTLLDQLDLLGRTSEMAKLIGIQFYEVLSRGSQFR 1554

Human  2590 VESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYN 2654
            |||||||||||.|.:|::||||.|:.||||:.:.|||||:||||::.::||||||||||::||||
  Fly  1555 VESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYN 1619

Human  2655 YCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQ-VRHD-ITVSPNGVAFVKPSVRKGVLPRML 2717
            ||||||||.||:||....|:||.:.|||...:|.: :.|| :||||.||.|||..||:|:|||||
  Fly  1620 YCFSTCLGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRML 1684

Human  2718 EEILKTRFMVKQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHK 2782
            .|||.||.|||||||.:|...||.|:|.:|||||||:||||:|||:||||||||.:|||||:|.|
  Fly  1685 TEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDSVVSK 1749

Human  2783 ARETLERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF 2847
            .|||||||||||.:.::|..|||||||||||||:.|..:.::|:||:|||:|||..||:|||||.
  Fly  1750 GRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKL 1814

Human  2848 EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISL 2912
            ||||.||:||||||||||||||.||:.||::||||||||||.||||:|:||:.|::||||:|:|.
  Fly  1815 EKVYQPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFETQDVSK 1879

Human  2913 IKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVP 2977
            ||.||.||..|||.|:|::||.|||||:||...|||.|||||||||||.:..|.|..|:.|||||
  Fly  1880 IKAYVCRQFTKLLSGRANLQDLIFAKEFRGLNGYKPTACVPALELTRKWMQKDPRHVPRRGERVP 1944

Human  2978 YVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSLIGIDVFSWYHELPRI 3042
            ::|:.|.||:.||:|||.|.::|.:...::||.|||||.|:|||.|...|||.:|..|:..||| 
  Fly  1945 FIIVNGPPGMQLIRLVRSPHDILANEGHKINAIYYITKAIIPPLNRCLLLIGANVHDWFASLPR- 2008

Human  3043 HK-------ATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQHGICSKCRSQPQHVAVILNQEI 3099
             |       .|::..:...|.|.||||||:|..|.: |...|:.|||..|........|:|:.:.
  Fly  2009 -KLLMTPAVGTANELAGARGAKSTISQYFSTTSCVIDCGRQTKAGICPDCLKNATTCVVVLSDKT 2072

Human  3100 RELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKAPYLRQLLD 3155
            ..|||..:...:||:.|.|... .:.|.||:||||:.|....|||.:..:..:||:
  Fly  2073 ARLERGYQLTRQICQACCGRLG-SLQCDSLDCPVLYVLEGKRRELQQIEHWNKLLE 2127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
REV3LXP_011534330.1 DUF4683 748..1134 CDD:292363 44/395 (11%)
DNA_polB_zeta_exo 2295..2559 CDD:99821 93/266 (35%)
POLBc 2317..2818 CDD:214691 260/505 (51%)
POLBc_zeta 2585..3033 CDD:99917 291/449 (65%)
DNA_pol_B 2585..3032 CDD:278562 291/448 (65%)
zf-C4pol 3069..3136 CDD:290959 23/67 (34%)
DNApol-zetaNP_524881.2 PTZ00166 20..>196 CDD:240301 94/175 (54%)
DNA_polB_zeta_exo 1297..1518 CDD:99821 90/260 (35%)
POLBc_zeta 1550..2000 CDD:99917 291/449 (65%)
zf-C4pol 2041..2107 CDD:405022 22/66 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 584 1.000 Domainoid score I205
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1174 1.000 Inparanoid score I198
Isobase 1 0.950 - 0 Normalized mean entropy S3397
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D20210at2759
OrthoFinder 1 1.000 - - FOG0001033
OrthoInspector 1 1.000 - - oto90299
orthoMCL 1 0.900 - - OOG6_102751
Panther 1 1.100 - - LDO PTHR45812
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R348
SonicParanoid 1 1.000 - - X3116
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.810

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