DRSC/TRiP Functional Genomics Resources

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Protein Alignment RET and Src64B

DIOPT Version :10

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster


Alignment Length:349 Identity:122/349 - (34%)
Similarity:172/349 - (49%) Gaps:58/349 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   687 YSSSGARRPSLD------SMENQVSVDAFKILEDP-----------------KWEFPRKNLVLGK 728
            |.::....|||.      |.||.:.:  ..||..|                 |:|.||..:.|.:
  Fly   227 YIATNQTFPSLQALVMAYSKENALGL--CHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLR 289

Human   729 TLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGA 793
            .||.|.||:|     |:.|.| ....||||.|:|....:..  .|.|..::|:..|..::.||..
  Fly   290 KLGRGNFGEV-----FYGKWR-NSIDVAVKTLREGTMSTAA--FLQEAAIMKKFRHNRLVALYAV 346

Human   794 CSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQI 858
            |||:.|:.::.||...|||..||||.                      |.|.|...|||..|.|:
  Fly   347 CSQEEPIYIVQEYMSKGSLLDFLREG----------------------DGRYLHFEDLIYIATQV 389

Human   859 SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL 923
            :.||:||...:|:||||||||:|:.|....||.||||:| |..:|.|..:...|.||||.|.|::
  Fly   390 ASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLAR-VIADDEYCPKQGSRFPVKWTAPEAI 453

Human   924 FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDN--CSEEMYRLMLQ 986
            ....::.:|||||:|:||.|:.|.|..||||:....:...::.|.||.:|.|  ..:.:|:|:||
  Fly   454 IYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQ 518

Human   987 CWKQEPDKRPVFADISKDLEKMMV 1010
            ||...|:|||.|..::...|...|
  Fly   519 CWDAVPEKRPTFEFLNHYFESFSV 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581 29..153
Cadherin 172..261 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581 265..379
RET_CLD3 265..379 CDD:465516
RET_CLD4 404..506 CDD:465517
Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581 405..506
PTKc_RET 723..1012 CDD:173631 108/290 (37%)
Src64BNP_001286937.1 SH2_Src_family 158..259 CDD:199827 9/33 (27%)
PTKc_Src_like 289..538 CDD:270630 105/279 (38%)
SH3_Src_like 99..150 CDD:212779
Blue background indicates that the domain is not in the aligned region.

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