DRSC/TRiP Functional Genomics Resources

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Protein Alignment RET and Abl

DIOPT Version :10

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster


Alignment Length:425 Identity:138/425 - (32%)
Similarity:218/425 - (51%) Gaps:55/425 - (12%)


- Green bases have known domain annotations that are detailed below.


Human   685 VSYSSSGARRPSLDSMENQVSVDAFKILEDP-KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKG 748
            |.:...|...|.|.....|.....|.:..:| :||..|.::::...||.|::|:|.:|    :..
  Fly   349 VPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEA----VWK 409

Human   749 RAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR 813
            |.| .|||||.|||:.  ..|:|.|.|..::|::.||::::|.|.|:::.|..:|.|:..:|:|.
  Fly   410 RYG-NTVAVKTLKEDT--MALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLL 471

Human   814 GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAAR 878
            .|||              |....:||     |:.   |:..|.||:.||.||.....:|||||||
  Fly   472 DFLR--------------SAGRETLD-----AVA---LLYMATQIASGMSYLESRNYIHRDLAAR 514

Human   879 NILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE 943
            |.||.:.:.:|::||||:| :..:|:|...:..:.|:||.|.|.|..:.::|:||||:|||||||
  Fly   515 NCLVGDNKLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWE 578

Human   944 IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 1008
            |.|.|.:|||.|....:::.|..|:|||||..|..|:|.||.|||:.:...||.|..|...||.|
  Fly   579 IATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHM 643

Human  1009 M--------VKRR---DYLDLAASTPSDSLIYDDGLSEEETPLVDC---NNAPLPRALPSTWIEN 1059
            .        |:::   :....::|.||.|.:...|.:...|....|   ::|....:|....::.
  Fly   644 FQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKK 708

Human  1060 KLYG---------MSDPNWPGESPVPLTRADGTNT 1085
            .|.|         .:||: ..::..|::....|:|
  Fly   709 GLPGGQALTPNAHHNDPH-QQQASTPMSETGSTST 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581 29..153
Cadherin 172..261 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581 265..379
RET_CLD3 265..379 CDD:465516
RET_CLD4 404..506 CDD:465517
Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581 405..506
PTKc_RET 723..1012 CDD:173631 112/296 (38%)
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189 4/13 (31%)
PTKc_Abl 382..644 CDD:270645 113/291 (39%)
FABD 1584..1723 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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