DRSC/TRiP Functional Genomics Resources

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Protein Alignment RET and Shark

DIOPT Version :10

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster


Alignment Length:325 Identity:108/325 - (33%)
Similarity:162/325 - (49%) Gaps:40/325 - (12%)


- Green bases have known domain annotations that are detailed below.


Human   699 SMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT---VAVKML 760
            |..:...|:|.|:    ::....:.|||.:.:|.||||.|.........| ||..:   ||:|||
  Fly   641 STPSATEVEAAKL----RFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSG-AGEESRLEVAIKML 700

Human   761 KENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIV-EYAKYGSLRGFLRESRKVGP 824
            .:..|..:  :.|.|.:|:.::.|..:::|.|...  |.:|::| |.|..||:..::        
  Fly   701 SDEHSNKQ--EFLREASVMMRLEHKCIVRLIGIAK--GEMLMMVQELAPLGSMLQYI-------- 753

Human   825 GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMK 889
                         |||..| .....:|..:|.||:.||.||.....|||||||||||:....:.|
  Fly   754 -------------LDHGHE-ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAK 804

Human   890 ISDFGLSRDVYEEDSYVKRSQ-GRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953
            |||||:||.:....:..:.:| ||.|::|.|.||....|::..||||||||.:||:.:||..||.
  Fly   805 ISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYG 869

Human   954 GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDL 1018
            .|.......|:.:|.|:.:|:.|...:|.:|..|||:.|..||.|.    .|.:...:..||.:|
  Fly   870 EISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFV----YLTEFFARDPDYQNL 930

Human  1019  1018
              Fly   931  930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581 29..153
Cadherin 172..261 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581 265..379
RET_CLD3 265..379 CDD:465516
RET_CLD4 404..506 CDD:465517
Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581 405..506
PTKc_RET 723..1012 CDD:173631 101/293 (34%)
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 98/290 (34%)
Blue background indicates that the domain is not in the aligned region.

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