Protein Alignment RET and Csk

DIOPT Version :10

• Sequence 1: NP_066124.1
• Gene: RET / 5979
• HGNCID: 9967
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 864
• Identity: 211/864 - (24%)
• Similarity: 312/864 - (36%)
• Gaps: 282/864 - (32%)

Human   306 ASGE-----------LVRRYTSTLLPGD--------TWAQQTFRVEH-----WPNET--SVQANG 344
            ||||           |:|:.|:|...|.        |...||..|.|     .|:.|  :..|.|
  Fly   301 ASGEGDLITVEIKQGLLRKQTATTTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATG 365

Human   345 S------FVRATVHDY----RLVLNRNLSISENRTMQLAVLVNDSDFQGPGA--GVLLLHFNV-- 395
            |      |::.|.|..    .|..|:..:...|     |||...|....||:  |.:|||...
  Fly   366 STAGDPWFLQTTGHQMPPTAPLRHNKRPAPQPN-----AVLGAGSSGTAPGSAVGAVLLHQQQLS 425

Human   396 ---------------------SVLPV------SLHLPSTYSLS----VSRRARRFAQIGKVCVEN 429
                                 :|.|:      :||| |:::|:    :|..:....:......:.
  Fly   426 QSQPHIVPPSIPPHHHHHRENNVHPIQAGAAAALHL-SSHALNSHNLISSASNHSPKSPSQTQQQ 489

Human   430 CQAFSGINVQYKLHSSGANCSTL--GVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQT 492
            .|..:....|.:..:|.:..||.  ....:|...:|...|..|.|            .||...|.
  Fly   490 QQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAA------------AVAAVAQQ 542

Human   493 SRQAQAQLLVTVE----------------GSYVAEEAGCPLSCAVS------------------- 522
            .:|...|||....                |.:.||.|..|.|.|:|
  Fly   543 QQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQA 607

Human   523 -----------------KRRLECEECGGLGSPTG---RCEWRQGDGKGITRNFSTCSPSTKTCPD 567
                             ...|...:..|:.:.:|   ...|..|....:  |.::.||:......
  Fly   608 SQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAM--NHASLSPTALAPQQ 670

Human   568 G--HCDVVETQDINICPQDCLRGSI--------VGGHEPG-----EPRGIKAGYGTCNCFPE--- 614
            |  .|:|    .:|..|  ...|||        :...|.|     |.......|..|.||..
  Fly   671 GRSRCEV----KLNAMP--WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVE 729

Human   615 -------EEKCFCEPEDIQDPL----------CDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHK 662
                   |.|...:.|:..:.|          .|.||..:|.                |:
  Fly   730 HYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIK----------------CL----- 773

Human   663 FAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLG 727
                                            |.|...|..::...|   .|..|..|...|.|.
  Fly   774 --------------------------------PKLGKQEFCINSKDF---VDKGWVIPEAELQLR 803

Human   728 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYG 792
            :::|:||||.|:.....:.|       |||||||:..:   ::..|:|.:|:..:.|.:::|..|
  Fly   804 ESIGKGEFGDVMLGILRNEK-------VAVKMLKDEGA---VQKFLAEASVMTTLEHDNLVKFIG 858

Human   793 ACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ 857
            .......|.|:.||...|||..:||                 |....|     :|..|.|.||:.
  Fly   859 LVFTSKHLYLVTEYMSKGSLVDYLR-----------------SRGRQH-----ITKKDQIIFAYD 901

Human   858 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIES 922
            .:.||:||...|:|||||||||:|::|....|:|||||:|    |:.| ....|::|:||.|.|:
  Fly   902 TASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR----EECY-NLDVGKLPIKWTAPEA 961

Human   923 LFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQC 987
            |.:..::.:||:||||:|||||.:.|..|||.||...:...::.|::||.|:.|..|:|.:|.|.
  Fly   962 LKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQA 1026

Human   988 WKQEPDKRPVFADISKDLE 1006
            |...|.|||.||::...|:
  Fly  1027 WDLNPAKRPTFAELKVKLQ 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	RET_CLD1	29..154	CDD:465485
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581	29..153
		Cadherin	172..261	CDD:394985
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581	265..379		28/108 (26%)
		RET_CLD3	265..379	CDD:465516	28/108 (26%)
		RET_CLD4	404..506	CDD:465517	21/123 (17%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581	405..506		20/122 (16%)
		PTKc_RET	723..1012	CDD:173631	104/284 (37%)
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	22/151 (15%)
		PTKc_Csk_like	793..1047	CDD:270635	106/290 (37%)