Protein Alignment RET and FER

DIOPT Version :10

• Sequence 1: NP_066124.1
• Gene: RET / 5979
• HGNCID: 9967
• Length: 1114
• Species: Homo sapiens
• Sequence 2: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 1003
• Identity: 240/1003 - (23%)
• Similarity: 379/1003 - (37%)
• Gaps: 276/1003 - (27%)

Human   146 YFSFFNTSFPACSSLKPRELCFPETRPSFR-------IRENRPPG-------TFHQFR-LLPVQF 195
            :|...:|..||....:.|:..|.:.:|..:       ||:...|.       |.|:.| ...|.:
  Fly   457 HFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHY 521

Human   196 LCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMV--PF 258
            |...|:.:          ....||         |.|.:|.:..::.:     |..||.|::  |.
  Fly   522 LGEEIATS----------STNPPD---------LTRLRRTQCSMLCL-----GEDEEPVVLASPA 562

Human   259 PVTVYDEDDSAPTFPAGVDTAS------AVVEFKRKEDTVVA-------------TLRVFDADVV 304
            |:|         ...|.|.|.:      |.:|..:|:||..:             .:|:......
  Fly   563 PLT---------QLTAAVLTNTNNNHIYADLELDKKKDTSPSPECKGEQIQPKKEQIRIEINQTA 618

Human   305 PASG---------ELVR----RYTSTLLPGDTWAQ---------QTFRVEHWPNETSVQANGS-- 345
            |.:.         ||.|    |...||.|.|....         ||.::...|:..:.:::.|
  Fly   619 PQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSS 683

Human   346 ---FVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPST 407
               ..:.|.|..:    |:||.|:.....:        |..      |..|:.|.|   :.:...
  Fly   684 ECRSSKDTSHSKK----RSLSFSQKSISNI--------FSN------LKEFSKSPL---VRMGKN 727

Human   408 YSLSVSRRARR------FAQIGKVCVEN-CQAFSGINVQYKLHSSGAN--CSTLGVVTSAEDTSG 463
            :.|:..:.|:|      ....|..|..| ..:.|..|...|..||.:|  .|...::||...|:
  Fly   728 HILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTT- 791

Human   464 ILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLEC 528
              ....|......:.:.|.:.|....:::.         .:..::.::.....|     ||...|
  Fly   792 --ITTTTTTTPSKENSRLKFKVPKIQKKSK---------AIRNTFRSKLLNFQL-----KRSKPC 840

Human   529 EECGGLGSPTGRCEWRQGDGKGI---TRNFSTCSPSTKTCPDGHCDVVETQDINICP---QDCLR 587
            ::|      |.|  .|....|.:   .:.|....|:.....:..|:         ||   |..::
  Fly   841 KQC------TKR--RRIHPSKSVFDFAKEFEVEQPAGSAADEQFCN---------CPPAGQKPVK 888

Human   588 GSI-VGGHE-------PGE-----PRGIKAGYGTCNCFPEEEK-----------CFCEPE----- 623
            .|: :.||:       .||     .|.|.      |...||:.           |:|.|.
  Fly   889 PSVQISGHKDHPFESSSGELDENSDRDID------NDEEEEDSASDDVLSMKDHCYCVPSLAASI 947

Human   624 --DIQDPLCDE------LCRTVIAAAVL--FSFIV---------SVLLSAFCIHCYHKFAHKPPI 669
              ....||.:|      |.|..:...:.  ..|:|         .::||.    |::...|....
  Fly   948 SLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSV----CWNGHKHFIVQ 1008

Human   670 SSAEMTFRRPAQAFPV-------SYSSSGARRPSLDSMENQVSVDAFKILEDP----KWEFPRKN 723
            ::.|..||.....|..       .|.|           |..|:|.:..||..|    :||....:
  Fly  1009 TTGEGNFRFEGPPFASIQELIMHQYHS-----------ELPVTVKSGAILRRPVCRERWELSNDD 1062

Human   724 LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVI 788
            :||.:.:|.|.||.|.||     |.::....||||..:......:.|..|.|..:|||.:||:::
  Fly  1063 VVLLERIGRGNFGDVYKA-----KLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIV 1122

Human   789 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS 853
            ||.|.|.|..|:::::|....|||..:||               :||:        .||....:.
  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLR---------------KNSN--------GLTTRQQMG 1164

Human   854 FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM 918
            .....:.||:||.....:||||||||.||.....:||||||:||:  ||:..|.....:|||||.
  Fly  1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWT 1227

Human   919 AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983
            |.|:|....||:..||||:|:|:|||.:.|..||.|:...|....:.||:||..|.:..||||||
  Fly  1228 APEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRL 1292

Human   984 MLQCWKQEPDKRPVFADISKDLEKMMVK 1011
            |||||..:.:.||.|.:|...::.::::
  Fly  1293 MLQCWAADAESRPHFDEIYNVVDALILR 1320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RET	NP_066124.1	RET_CLD1	29..154	CDD:465485	2/7 (29%)
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581	29..153		1/6 (17%)
		Cadherin	172..261	CDD:394985	21/105 (20%)
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581	265..379		28/159 (18%)
		RET_CLD3	265..379	CDD:465516	28/159 (18%)
		RET_CLD4	404..506	CDD:465517	19/110 (17%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581	405..506		19/109 (17%)
		PTKc_RET	723..1012	CDD:173631	107/289 (37%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/100 (18%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/277 (38%)