DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RET and btl

DIOPT Version :9

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_001014583.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:752 Identity:227/752 - (30%)
Similarity:323/752 - (42%) Gaps:181/752 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   377 NDSDFQGP------GAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSG 435
            ||.|.:.|      |.|..:....:..|..||. .:|.:|:                  |..:..
  Fly   376 NDDDVENPAAEASGGVGPPVFRKELKRLQHSLS-GNTVNLA------------------CPVYGK 421

Human   436 INVQYKLHSSGANCS---------TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQ 491
            .|:.:.......|..         ||..|.:..:.||:.   :.|......|.:..:.|...|  
  Fly   422 ANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLY---NCKVCNAWGCIQFDFSVQIND-- 481

Human   492 TSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFS 556
              |...|.::|..:...|.......:.|.|....          .||  ..|:    :.:.:|.|
  Fly   482 --RTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDL----------HPT--VSWK----RVVLKNAS 528

Human   557 TCSPSTKTCPDGHCDVVETQDINICPQD-------------------CLRGSIVGGHEPGEPRGI 602
            .         || ...||.|::|....:                   ||..|             
  Fly   529 L---------DG-LKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASS------------- 570

Human   603 KAGYGTCNC---------FPEEEKCFCEPEDI-----QDPLCDELCRTVIAAAVLF--SFIVSVL 651
              |.|..|.         .|        |.:|     ..||...|....|.|..|.  :||..:|
  Fly   571 --GLGRSNSSVYLRVVSPLP--------PLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFML 625

Human   652 -------LSAFCIHCYHKFAHKPPI-----------SSAEM---TFRRPAQAFPVSYSSSGARRP 695
                   |....|...|::..|..|           ||.::   ..|...|...||.:.:|...|
  Fly   626 RRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDP 690

Human   696 SLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL--KGRAGYTTVAVK 758
            :....|.:..:|:       .||.||:.|.||..||||.||:||.|.|..|  ..:...|.||||
  Fly   691 AQGFNEYEFPLDS-------NWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVK 748

Human   759 MLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV 822
            |:||..:.:::..|:.|..|:|.: .|.::|.|.|.|||.|||.:|||||.:|:|:.||:::|..
  Fly   749 MVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPG 813

Human   823 GP-------GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNI 880
            .|       |||   ..:...|..|..|:.||     .||:||::||:|||..:.:||||||||:
  Fly   814 APQRRSDSDGYL---DDKPLISTQHLGEKELT-----KFAFQIARGMEYLASRRCIHRDLAARNV 870

Human   881 LVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 945
            ||::|..|||:||||:||:.:.:.|.|.:.||:|:||||.|||.:..|.:||||||:|||||||:
  Fly   871 LVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIM 935

Human   946 TLGGNPYPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
            |.|..|||.| ..|.|::.|.||.|||:|..||..:|.:|.|||..|...||.||::.:..:.::
  Fly   936 TYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGIL 1000

Human  1010 VKRRD-----YLDLA---ASTPSDSLIYDDGLSEEET 1038
            .:...     ||||:   ..||..|...||| |:.||
  Fly  1001 QQASSNPNDAYLDLSMPMLETPPSSGDEDDG-SDTET 1036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 Cadherin 172..261 CDD:278457
PTKc_RET 723..1012 CDD:173631 137/299 (46%)
Pkinase_Tyr 724..1005 CDD:285015 137/291 (47%)
Inhibitors binding 805..807 1/1 (100%)
btlNP_001014583.1 IG_like 149..232 CDD:214653
IGc2 157..215 CDD:197706
IG 247..336 CDD:214652
Ig 258..340 CDD:143165
I-set 394..479 CDD:254352 16/106 (15%)
IGc2 408..469 CDD:197706 11/82 (13%)
IG_like 492..583 CDD:214653 20/131 (15%)
Ig 507..583 CDD:299845 19/116 (16%)
PKc_like 700..1000 CDD:304357 142/314 (45%)
TyrKc 712..996 CDD:197581 137/291 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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