DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RET and Tie

DIOPT Version :10

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster


Alignment Length:430 Identity:132/430 - (30%)
Similarity:197/430 - (45%) Gaps:105/430 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   681 QAFPVSYSSSGARRPSLDSMENQVSVDAFKI-LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF 744
            ||.|:|.:|      ..|:..|:...:..|. |.....:|.|.|:.|...||||.||:|.||.|.
  Fly   816 QAMPMSQAS------QRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEAD 874

Human   745 HLKGRAGYT-TVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYA 807
            .|.|..|.| .||||.::..::...|:|   |.|::::: :|.:|:.|.|||.:..|.:||:|||
  Fly   875 DLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYA 936

Human   808 KYGSLRGFLRESR---KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMK 869
            ..|.|...||.:|   .:.|..:..|.|.          ..|:...|..||..|:.||:|:|..:
  Fly   937 MRGRLLSLLRAARSATNILPASVPGGRSL----------APLSPRTLAGFALDIACGMEYIAGRR 991

Human   870 LVHRDLAARNILVAEGRKMKISDFGLSRDVYEE---------------------------DSYV- 906
            :|||||||||:|:......||.|||:|.|:..|                           ..|: 
  Fly   992 IVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYIL 1056

Human   907 -------KRSQGR--------------------------IPVKWMAIESLFDHIYTTQSDVWSFG 938
                   .:.||:                          :|::|||.|||..|::||::|:|:||
  Fly  1057 QHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFG 1121

Human   939 VLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFA---- 999
            ::||||.|||..||..:....:...:..|.|.:.|.....|.|.||.:||.:||..||.||    
  Fly  1122 IVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRL 1186

Human  1000 DISKDLEKMM---VKRRDYLDLAASTPSDSLIYDDGLSEE 1036
            :|::.|.|.:   ....||:|::            |.||:
  Fly  1187 EITRSLHKWVDDDSAASDYMDVS------------GFSED 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581 29..153
Cadherin 172..261 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581 265..379
RET_CLD3 265..379 CDD:465516
RET_CLD4 404..506 CDD:465517
Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581 405..506
PTKc_RET 723..1012 CDD:173631 115/361 (32%)
TieNP_523928.1 TyrKc 854..1183 CDD:197581 110/341 (32%)
Blue background indicates that the domain is not in the aligned region.

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