DRSC/TRiP Functional Genomics Resources

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Protein Alignment RET and Src42A

DIOPT Version :10

Sequence 1:NP_066124.1 Gene:RET / 5979 HGNCID:9967 Length:1114 Species:Homo sapiens
Sequence 2:NP_001400996.1 Gene:Src42A / 35524 FlyBaseID:FBgn0264959 Length:1606 Species:Drosophila melanogaster


Alignment Length:307 Identity:114/307 - (37%)
Similarity:169/307 - (55%) Gaps:32/307 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT-VAVKMLKENASPSELRDLLSEFNVL 779
            :||..|.:|...:.||.|:||.|       .:|....|| ||:|.||  :...:.:|.|:|..::
  Fly  1329 QWEIDRTSLKFVRKLGSGQFGDV-------WEGLWNNTTPVAIKTLK--SGTMDPKDFLAEAQIM 1384

Human   780 KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDER 844
            |::.|..:|:||..|:.:.|:.:|.|..|:|||..:|:       ...|.|             |
  Fly  1385 KKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQ-------AIAGKG-------------R 1429

Human   845 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS 909
            :|.|..||..|.||:.||.||.....:||||||||:||.:|..:||:||||:| :.:||.|..|.
  Fly  1430 SLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLAR-LIKEDEYEARV 1493

Human   910 QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD 974
            ..|.|:||.|.|:.....::.:|||||||:||.|:||.|..||||:....:...::.|:||.:|.
  Fly  1494 GARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPP 1558

Human   975 NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDLAA 1020
            ||...:|.:||:||.::|.:||.|..:...||..... :.||.:..|
  Fly  1559 NCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKEAQA 1605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RETNP_066124.1 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000305|PubMed:11445581 29..153
Cadherin 172..261 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000305|PubMed:11445581 265..379
RET_CLD3 265..379 CDD:465516
RET_CLD4 404..506 CDD:465517
Cadherin-like region 4 (CLD4). /evidence=ECO:0000305|PubMed:11445581 405..506
PTKc_RET 723..1012 CDD:173631 108/290 (37%)
Src42ANP_001400996.1 SH2_Src_Src42 1210..1301 CDD:198233
PTKc_Frk_like 1328..1596 CDD:270653 111/296 (38%)
Blue background indicates that the domain is not in the aligned region.

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